[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100350622":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":33,"locations":43,"responsibleParty":61,"collaborators":63,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":18,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":18,"enrollmentInfo":76,"targetDuration":18,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":86,"overallStatus":46,"whyStopped":18,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Johns Hopkins University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Integrated AUD Treatment (IAT)","EXPERIMENTAL","IAT will include computer-delivered CBI in the hospital, nurse-delivered clinical monitoring and treatment adherence counseling, and at-home participation in web-based, 7-session computerized cognitive-behavioral therapy (CBT4CBT), supplemented by tailored text messages. Alcohol pharmacotherapy will be added to behavioral treatments as needed.",[13],"Behavioral: Integrated AUD Treatment",{"label":15,"type":16,"description":17,"interventionNames":18},"Treatment As Usual","NO_INTERVENTION","All LT patients receive physician instructions to not drink alcohol. Consistent with current discharge procedures, AH patients are encouraged to engage in alcohol treatment services. Patients receive regular blood draws for monitoring of liver function, and regular phone calls for post-operative monitoring.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Integrated AUD Treatment","IAT will include computer-delivered BI in the hospital, nurse-delivered alcohol monitoring counseling at each outpatient LT follow-up visit, and at-home participation in web-based, 7-session CBT4CBT, supplemented by tailored text messages.",[9],[26,27,28],"Computerized brief alcohol intervention (CBI)","CBT4CBT","Text Messaging",[30],{"name":31,"affiliation":5,"role":32},"Mary E McCaul, PhD","PRINCIPAL_INVESTIGATOR",[34,39],{"name":35,"role":36,"phone":37,"phoneExt":18,"email":38},"MARY E MCCAUL, PhD","CONTACT","410-955-9526","mmccaul1@jhmi.edu",{"name":40,"role":36,"phone":41,"phoneExt":18,"email":42},"Victor Chen, MD","410-550-1793","pchen37@jhmi.edu",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Johns Hopkins University School of Medicine","RECRUITING","Baltimore","Maryland","21205","United States","US",{"type":53,"coordinates":54},"Point",[55,56],-76.61219,39.29038,{"lat":56,"lon":55},[59],{"name":60,"role":36,"phone":37,"phoneExt":18,"email":38},"Mary E McCaul, Ph.D.",{"type":62,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[64],{"name":65,"class":66},"National Institute on Alcohol Abuse and Alcoholism (NIAAA)","NIH","100350622","alcohol-treatment-outcomes-following-early-vs-standard-liver-transplant-for-sah-100350622",false,"NCT03845205","Alcohol Treatment Outcomes Following Early vs. Standard Liver Transplant for SAH","Alcohol Treatment Outcomes Following Early vs. Standard Liver Transplant for Severe Alcoholic Hepatitis (SAH)","Inclusion Criteria:\n\n* English speaking\n\nExclusion Criteria:\n\n* too medically\u002Fpsychiatrically ill to participate\n* not able to provide informed consent due to cognitive impairment","ALL","18 Years",{"count":77,"type":78},200,"ESTIMATED","INTERVENTIONAL",[81],"NA","Given the severe consequences of alcohol relapse following liver transplantation for alcoholic hepatitis (AH-LT), it is critical to accurately identify alcohol use and implement alcohol interventions early in the post-transplant period to optimize patient outcomes. The proposed randomized clinical trial will examine the implementation and effects of integrated, person- and computer-delivered alcohol treatment compared to standard care on alcohol use (assessed by self-report and biomarker), mood, quality of life and survival following AH-LT. Predictors of 12-month post-transplant alcohol outcomes will be explored to allow future improved tailoring and targeting of these treatments.",[84,85],"Alcohol Use Disorder","Alcoholic Hepatitis",[87,88,89,90],"Alcohol treatment","Liver transplant","Motivational intervention","Cognitive-behavioral therapy","2026-06-05",{"date":93,"type":94},"2026-06-09","ACTUAL",{"date":96,"type":94},"2020-11-20",{"date":98,"type":78},"2027-06",{"name":5,"class":6},1]