[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100566116":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":28,"locations":37,"responsibleParty":61,"collaborators":18,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":18,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":83,"overallStatus":40,"whyStopped":18,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Technical University of Munich","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention Group","EXPERIMENTAL","This group receives exercise training",[13],"Other: Exercise training",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Group","NO_INTERVENTION","This group does not receive exercise training",null,[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":18},"Exercise training","exercise intervention will consist of supervised, home-based, combined training with elements of endurance, resistance and respiratory training",[9],[25],{"name":26,"affiliation":5,"role":27},"Simon Wernhart, MD","PRINCIPAL_INVESTIGATOR",[29,34],{"name":30,"role":31,"phone":32,"phoneExt":18,"email":33},"Martin Halle, Professor","CONTACT","+49 8928924441","martin.halle@mri.tum.de",{"name":35,"role":31,"phone":32,"phoneExt":18,"email":36},"Manuel Rattka, MD","manuel.rattka@mri.tum.de",[38],{"facility":39,"status":40,"city":41,"state":18,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Department of Medicine, Division of Prevention and Sports Medicine TU Munich","RECRUITING","Munich","80809","Germany","DE",{"type":46,"coordinates":47},"Point",[48,49],11.57549,48.13743,{"lat":49,"lon":48},[52,56,58],{"name":53,"role":31,"phone":54,"phoneExt":18,"email":55},"Martin Halle, Prof. M.D.","+49 89 289 - 24430","halle@mri.tum.de",{"name":57,"role":27,"phone":18,"phoneExt":18,"email":18},"Simon Wernhart, M.D.",{"name":59,"role":60,"phone":18,"phoneExt":18,"email":18},"Veronika Schmid, BA","SUB_INVESTIGATOR",{"type":62,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100566116","alex-dhf-ablation-and-exercise-in-diastolic-heart-failure-100566116",false,"NCT06650995","AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure","AlEX-DHF","Inclusion Criteria:\n\n* Diagnosed heart failure with preserved ejection fraction\n* Symptomatic short-persistent atrial fibrillation (diagnosis within 1 year of study inclusion)\n\nExclusion Criteria:\n\n* Paroxysmal, long-persistent or permanent atrial fibrillation\n* Clinically unstable coronary artery disease or acute coronary syndrome\n* Physical and\u002For mental inability to perform exercise testing\n* Prior ablation therapy\n* Precapillary pulmonary hypertension at rest\n* Intracardiac shunts\n* Left ventricular ejection fraction \\\u003C50%\n* High-degree valve insufficiency or stenosis (greater than grade 1 at rest)","ALL","18 Years","99 Years",{"count":74,"type":75},40,"ESTIMATED","INTERVENTIONAL",[78],"NA","The investigators analyze the impact of exercise and ablation in patients with symptomatic short-persistent atrial fibrillation (Afib) and heart failure with preserved ejection fraction (HFpEF). It is hypothesized that the combination of ablation and exercise better improves peak oxygen consumption (VO2peak) through improvement of peripheral (exercise training) and central (ablation) adaptations.\n\nExercise intervention will contain a 12-week combined, video-based, supervised, endurance, resistance and respiratory training.",[81,82],"HFpEF - Heart Failure With Preserved Ejection Fraction","Atrial Fibrillation",[84,85],"exercise capacity","ablation","2025-12-18",{"date":88,"type":89},"2025-12-26","ACTUAL",{"date":91,"type":75},"2026-02-01",{"date":93,"type":75},"2027-06-30",{"name":5,"class":6},1]