[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100559150":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":44,"responsibleParty":72,"collaborators":26,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":26,"eligibilityCriteria":80,"healthyVolunteers":76,"sex":81,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":26,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":94,"overallStatus":63,"whyStopped":26,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"GenieBiome Limited","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active arm","ACTIVE_COMPARATOR","Subjects will receive 1 sachet of BLHK03 daily from the start of the chemotherapy cycle to 2 months after the final dose of chemotherapy.",[13],"Dietary Supplement: BLHK03",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo arm","PLACEBO_COMPARATOR","Subjects will receive 1 sachet of active placebo daily from the start of the chemotherapy cycle to 2 months after the final dose of chemotherapy.",[19],"Dietary Supplement: Active placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","BLHK03","BLHK03 consists of a blend of probiotics (20 billion CFU in 1 sachet) and prebiotic compounds",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Active placebo","Active placebo contains 5mcg of Vitamin B7",[15],[32],{"name":33,"affiliation":5,"role":34},"Jessica Ching, PhD","STUDY_DIRECTOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Emily Chiu, BSc","CONTACT","97405209","emilychiu@g-niib.com",{"name":42,"role":38,"phone":39,"phoneExt":26,"email":43},"Pui Kuan Cheong, MPH","jcheong@g-niib.com",[45,61],{"facility":5,"status":46,"city":47,"state":26,"zip":26,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"NOT_YET_RECRUITING","Hong Kong","HK",{"type":50,"coordinates":51},"Point",[52,53],114.17469,22.27832,{"lat":53,"lon":52},[56,58],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":57},"jessicaching@g-niib.com",{"name":59,"role":60,"phone":26,"phoneExt":26,"email":26},"Henry Chun Kin Sze, MD","PRINCIPAL_INVESTIGATOR",{"facility":62,"status":63,"city":47,"state":26,"zip":26,"country":47,"countryCode":48,"cosmosGeoPoint":64,"geoPoint":66,"contacts":67},"Heal Medical","RECRUITING",{"type":50,"coordinates":65},[52,53],{"lat":53,"lon":52},[68,71],{"name":69,"role":38,"phone":70,"phoneExt":26,"email":40},"Emily Chiu, Bsc","9740 5209",{"name":33,"role":38,"phone":70,"phoneExt":26,"email":57},{"type":73,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100559150","alleviation-of-alopecia-in-breast-cancer-patient-using-synbiotics-formula-100559150",false,"NCT06560385","Alleviation of Alopecia in Breast Cancer Patient Using Synbiotics Formula","A Pilot, Double-blind, Randomised, Placebo-controlled Trial on the Efficacy of a Synbiotic Formula (BLHK03) in Alleviating Chemotherapy-induced Alopecia (CIA) in Breast Cancer Patients","Inclusion Criteria:\n\n* Females aged between 18 and 60 years who are newly diagnosed with stage I, II or III breast cancer\n* Planned chemotherapy including an anthracycline or taxane to be completed within 6 months\n* Mentally capable to participate in the study and provide informed consent\n\nExclusion Criteria:\n\n* Pre-existing female-pattern baldness resembling picture I-3 or higher on the Savin scale at baseline\n* History of hair transplantation, psoriasis or severe scalp infection\n* Undergoing or plan to receive scalp cooling\n* Plan for immunotherapy\n* Known pregnancy or lactating\n* Severe cardiac, hepatic, renal, pulmonary and haematic lesions or other life-threatening conditions\n* Use of antibiotics, probiotics or prebiotics one month prior to enrolment\n* No other alternative or complementary treatment for the cancer condition that may affect the gut microbiome analysis\n* History of allergy to probiotics or lactose\n* History of chemotherapy for other conditions","FEMALE","18 Years","60 Years",{"count":85,"type":86},40,"ESTIMATED","INTERVENTIONAL",[89],"NA","This study aims to explore the efficacy and safety of a synbiotic formula (BLHK03) in alleviating chemotherapy-induced alopecia (CIA) in breast cancer patients and the compositional and functional changes in the gut microbiome of breast cancer patients undergoing chemotherapy and treatment with BLHK03.",[92,93],"Breast Cancer","Hair Loss",[92,93,95,96],"Chemotherapy","Synbiotic","2024-09-11",{"date":99,"type":100},"2024-09-19","ACTUAL",{"date":97,"type":100},{"date":103,"type":86},"2026-08-18",{"name":5,"class":6},2]