[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100374560":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":14,"locations":25,"responsibleParty":49,"collaborators":10,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":10,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":10,"maxAge":10,"enrollmentInfo":59,"targetDuration":62,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":27,"whyStopped":10,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Alpha-1 Foundation","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Alpha-1 Diagnosed Individuals",null,"Larger patient cohorts are needed to support the clinical trials coming in the next 3-5 years. Despite widespread invitations to the Alpha-1 community from the Alpha-1 Foundation Research Registry, it is estimated that the Alpha-1 Foundation Research Registry now contains \\\u003C40% of the identified PiZZ individuals in the US.",{"label":13,"type":10,"description":11,"interventionNames":10},"Carriers of Alpha-1",[15,21],{"name":16,"role":17,"phone":18,"phoneExt":19,"email":20},"Alison Keaveny, MBBS","CONTACT","1-877-228-7321","252","akeaveny@alpha1.org",{"name":22,"role":17,"phone":18,"phoneExt":23,"email":24},"Randel Plant","306 or 245","rplant@alpha1.org",[26],{"facility":5,"status":27,"city":28,"state":29,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"RECRUITING","Coral Gables","Florida","33134","United States","US",{"type":34,"coordinates":35},"Point",[36,37],-80.26838,25.72149,{"lat":37,"lon":36},[40,42,46],{"name":16,"role":17,"phone":41,"phoneExt":19,"email":20},"877-228-7321",{"name":43,"role":17,"phone":18,"phoneExt":44,"email":45},"Nadine Nuchovich, MPH","245","nnuchovich@alpha1.org",{"name":47,"role":48,"phone":10,"phoneExt":10,"email":10},"Jeanine D'Armiento, MD, PhD","PRINCIPAL_INVESTIGATOR",{"type":50,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100374560","alpha-1-research-registry-100374560",false,"NCT04157049","Alpha-1 Research Registry","Alpha-1 Research Registry Protocol","Inclusion Criteria:\n\n* Patients diagnosed with Alpha-1 Antitrypsin Deficiency (PiZZ, PiZNull, PiSZ etc.)\n* Alpha-1 carriers (PiMZ, PiMS etc.)\n\nExclusion Criteria:\n\n* Failure to provide informed consent\n* Normal healthy individuals (MM)","ALL",{"count":60,"type":61},4000,"ESTIMATED","2 Years","OBSERVATIONAL","The Alpha-1 Research Registry is a confidential database made up of individuals diagnosed with Alpha-1 Antitrypsin Deficiency (Alpha-1) and individuals identified as Alpha-1 carriers. The Registry was established to facilitate research initiatives and promote the development of improved treatments and a cure for Alpha-1.",[66],"Alpha 1-Antitrypsin Deficiency",[68,69,70,71,72,73,74,75,76,77],"AATD","ALPHA 1","COPD","AAT","ZZ","MZ","CARRIER","MM","MS","PiZZ","2024-01-29",{"date":80,"type":81},"2024-01-30","ACTUAL",{"date":83,"type":81},"2019-06-20",{"date":85,"type":61},"2029-06-20",{"name":5,"class":6},1]