[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100156990":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":16,"locations":21,"responsibleParty":37,"collaborators":10,"id":40,"slug":41,"hasResults":42,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":10,"eligibilityCriteria":46,"healthyVolunteers":42,"sex":47,"minAge":48,"maxAge":10,"enrollmentInfo":49,"targetDuration":10,"studyType":52,"phases":10,"briefSummary":53,"conditions":54,"keywords":59,"overallStatus":63,"whyStopped":10,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":71,"locationsCount":72},{"fullName":5,"class":6},"The University of Texas Health Science Center, Houston","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Multi-organ failure",null,"Alveolar dead space on mechanically ventilated patients with severe sepsis or septic shock.",[13],{"name":14,"affiliation":5,"role":15},"Rosa M Estrada-Y-Martin, MD MSc","PRINCIPAL_INVESTIGATOR",[17],{"name":14,"role":18,"phone":19,"phoneExt":10,"email":20},"CONTACT","713-500-6830","rosa.m.estrada.y.martin@uth.tmc.edu",[22],{"facility":23,"status":10,"city":24,"state":25,"zip":26,"country":27,"countryCode":28,"cosmosGeoPoint":29,"geoPoint":34,"contacts":35},"Memorial Hermann Hospital","Houston","Texas","77030","United States","US",{"type":30,"coordinates":31},"Point",[32,33],-95.36327,29.76328,{"lat":33,"lon":32},[36],{"name":14,"role":18,"phone":19,"phoneExt":10,"email":20},{"type":15,"investigatorFullName":38,"investigatorTitle":39,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Rosa Estrada Y Martin","Associate Professor - IM, Critical Care","100156990","alveolar-dead-space-as-predictor-of-organ-failure-in-severe-sepsis-100156990",false,"NCT01315782","Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis","Alveolar Dead Space as Predictor of Multi-organ Failure and Mortality in Medical Intensive Care Patients With Sepsis Requiring Mechanical Ventilation","Inclusion Criteria:\n\n* Adults with severe sepsis or septic shock on mechanical ventilation\n* Enrolled in the initial six hours of ICU admission\n\nExclusion Criteria:\n\n* Patients with withdrawal or hospice order.\n* Patients with terminal, irreversible disease, expect to decease in 48 hours from ICU admission.\n* Patients with COPD.\n* Patients transferred from outside ICU with ongoing sepsis management for more than six hours.","ALL","18 Years",{"count":50,"type":51},30,"ESTIMATED","OBSERVATIONAL","This is an observational study to understand the changes in alveolar dead space in medical critically ill patients with severe infection (severe sepsis) requiring mechanical ventilation and the possibility to predict multi-organ failure.\n\nThe measurement of alveolar dead space used to require sophisticated equipment and time. New ventilators have microprocessors that allow rapid mathematical calculation with minimal intervention.",[55,56,57,58],"Sepsis","Severe Sepsis","Septic Shock","Multi-organ Failure",[55,60,61,62,9],"Severe sepsis","Septic shock","Alveolar dead space","NOT_YET_RECRUITING","2025-06-10",{"date":66,"type":67},"2025-06-11","ACTUAL",{"date":69,"type":51},"2026-12",{"date":69,"type":51},{"name":5,"class":6},1]