[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100568053":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":31,"centralContacts":36,"locations":46,"responsibleParty":66,"collaborators":69,"id":87,"slug":88,"hasResults":89,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":25,"eligibilityCriteria":93,"healthyVolunteers":89,"sex":94,"minAge":95,"maxAge":96,"enrollmentInfo":97,"targetDuration":25,"studyType":100,"phases":101,"briefSummary":103,"conditions":104,"keywords":106,"overallStatus":112,"whyStopped":25,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":122},{"fullName":5,"class":6},"Food and Nutrition Research Institute, Philippines","OTHER_GOV",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention Arm","EXPERIMENTAL","complementary food supplemented with indispensable amino acid (IAA) mix",[13,14],"Dietary Supplement: IAA mix supplement","Other: Complementary food comprised of rice and legumes",{"label":16,"type":10,"description":17,"interventionNames":18},"Control Group","complementary food without IAA mix",[14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","IAA mix supplement","The intervention is a daily IAA dose that provides x1.5 the estimated average requirement (EAR) for a healthy child. This IAA dose will be mixed to the complementary food and will be taken once daily for 4 weeks (28 days) by the child in the intervention group.",[9],null,{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":25},"OTHER","Complementary food comprised of rice and legumes","Each study child will receive standard complementary food which he\u002Fshe will take once daily for 4 weeks (28 days)",[16,9],[32],{"name":33,"affiliation":34,"role":35},"Amster Fei P. Baquiran, BS Chemistry","Department of Science and Technology Food and Nutrition Research Institute","PRINCIPAL_INVESTIGATOR",[37,42],{"name":33,"role":38,"phone":39,"phoneExt":40,"email":41},"CONTACT","+632 8837 8113","341","afpbaquiran@gmail.com",{"name":43,"role":38,"phone":39,"phoneExt":44,"email":45},"Carl Vincent D. Cabanilla, BS Chemistry","307","cvdcabanilla@gmail.com",[47],{"facility":48,"status":25,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Department of Science and Technology - Food and Nutrition Research Institute","City of Taguig","National Capital Region","1631","Philippines","PH",{"type":55,"coordinates":56},"Point",[57,58],121.0792,14.5243,{"lat":58,"lon":57},[61,65],{"name":62,"role":38,"phone":39,"phoneExt":63,"email":64},"Michael E. Serafico, PhD Chemistry","329","michaelserafico@gmail.com",{"name":33,"role":38,"phone":25,"phoneExt":25,"email":25},{"type":35,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Amster Fei Baquiran","Senior Science Research Specialist",[70,72,74,77,79,81,83,85],{"name":71,"class":6},"International Atomic Energy Agency",{"name":73,"class":27},"University of Glasgow",{"name":75,"class":76},"Ghana Atomic Energy Commission","UNKNOWN",{"name":78,"class":27},"Kamuzu University of Health Sciences",{"name":80,"class":27},"University of Zambia",{"name":82,"class":27},"Rutgers, The State University of New Jersey",{"name":84,"class":27},"St. John's Research Institute",{"name":86,"class":76},"cnesten, Morocco","100568053","amino-acid-supplementation-in-children-with-stunting-100568053",false,"NCT06676215","Amino Acid Supplementation in Children with Stunting","Efficacy of Amino Acid Supplementation on Gut Function and Nutritional Status in FIlipino Children Below Three Years Old","Inclusion Criteria:\n\n* 18 to 36 months old (of either sex)\n* Stunted (LAZ of less than -2)\n* Parent, caregiver or guardian able and willing to give written, informed consent\n\nExclusion Criteria:\n\n* Wasted (WHZ of less than -2)\n* Overweight (WHZ of more than 2)\n* Have had diarrhea (by self-report) in the preceding month\n* Sibling or twin of another participating study child (2 children of different families in the same household are both eligible)\n* Have taken antibiotics in the preceding month\n* Have food allergies\u002Fintolerance\n* Had a serious illness within the last three (3) months or have any underlying condition which in the opinion of the pediatrician would put the subject at undue risk of failing study completion or would interfere with analysis of study results","ALL","18 Months","36 Months",{"count":98,"type":99},60,"ESTIMATED","INTERVENTIONAL",[102],"NA","The goal of this intervention study is to determine the effects of indispensable amino acid (IAA) supplementation on children of either sex, aged 18 to 36 months. The main questions it aims to answer are:\n\n* Does IAA supplementation affect biomarkers of Environmental Enteric Dysfunction (EED), through the Dual Sugar Lactulose\u002FRhamnose (L\u002FR) test, plasma intestinal fatty acid binding protein, plasma lipopolysaccharide binding protein, fecal myeloperoxidase, fecal neopterin, and gut microbiota?\n* Does IAA supplementation impact amino acid digestion, as assessed by a dual-stable isotope tracer?\n* What is the weight gain and the changes in length-for-Age z-scores (LAZ) and body composition?\n\nThe researchers will compare the effects of consumption of standard complementary food with added IAA against a control group that has no added IAA through the assessment of the various biomarkers.\n\nParticipants will:\n\n* answer questions regarding personal, demographic, anthropometric, and food intake information.\n* provide biological samples, including breath, urine, stool, blood, and saliva.\n* consume solutions or meals that contain sugars and\u002For stable isotope tracers.\n* visit the FNRI and receive house visits by study staff.\n* consume complementary food with or without supplement daily for 28 days.",[105],"Stunted Growth",[107,108,109,110,111],"Amino Acid Supplementation","Gut Function","Nutritional Interventions","Stunting","Children Below 3 Years Old","NOT_YET_RECRUITING","2024-11-04",{"date":115,"type":116},"2024-11-06","ACTUAL",{"date":118,"type":99},"2025-02-01",{"date":120,"type":99},"2025-12",{"name":5,"class":6},1]