[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625809":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":18,"locations":25,"responsibleParty":49,"collaborators":18,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":18,"eligibilityCriteria":56,"healthyVolunteers":53,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":18,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":70,"overallStatus":28,"whyStopped":18,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Chronic Conditions Research Fund","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Amygdala insula retraining","EXPERIMENTAL","Participants receive immediate access to the 12-week Amygdala and Insula Retraining (AIR) program in addition to treatment as usual.",[13],"Behavioral: Amygdala and Insula Retraining (AIR)",{"label":15,"type":16,"description":17,"interventionNames":18},"Control","NO_INTERVENTION","Participants receive treatment as usual for 12 weeks and are offered access to the Amygdala and Insula Retraining (AIR) program after completion of the primary outcome assessment.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"BEHAVIORAL","Amygdala and Insula Retraining (AIR)","Mind-body brain retraining intervention",[9],[26],{"facility":27,"status":28,"city":29,"state":30,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"Luther College Department of Psychology","RECRUITING","Decorah","Iowa","52101","United States","US",{"type":35,"coordinates":36},"Point",[37,38],-91.78571,43.30331,{"lat":38,"lon":37},[41,47],{"name":42,"role":43,"phone":44,"phoneExt":45,"email":46},"Loren Toussaint, Ph.D., Ph.D. in Psychology","CONTACT","312-768-8649","Kate-R Manager","kate@ccrfund.org",{"name":48,"role":43,"phone":44,"phoneExt":18,"email":46},"Kate Research Manager",{"type":50,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100625809","amygdala-insula-retraining-in-the-management-of-perimenopause-symptoms-100625809",false,"NCT07427459","Amygdala Insula Retraining in the Management of Perimenopause Symptoms","Inclusion Criteria:\n\n* Experiencing perimenopausal symptoms\n* Meets STRAW+10 criteria based on self-assessment (-2 to +1c)\n* Able to read and understand English\n* Access to internet\n\nExclusion Criteria:\n\n* Pregnancy\n* Presence of a severe psychiatric condition requiring immediate clinical intervention\n* Uncontrolled thyroid disease or prolactinoma\n* Active cancer treatment\n* Inability to provide informed consent\n* Any medical or psychiatric condition that, in the judgment of the investigator or study team, would interfere with safe participation or study completion","FEMALE","38 Years","60 Years",{"count":61,"type":62},160,"ESTIMATED","INTERVENTIONAL",[65],"NA","The goal of this study is to evaluate a neuroplasticity-based mind-body intervention, Amygdala and Insula Retraining (AIR), compared to a wait-list control in individuals experiencing perimenopausal symptoms.\n\nOur research questions include:\n\nDoes AIR reduce overall perimenopausal symptom burden compared to a wait-list control?\n\nDoes AIR improve sleep disturbance, vasomotor symptom interference, fatigue, mood, anxiety, and quality of life in perimenopausal individuals?\n\nAre symptom changes associated with improvements in autonomic regulation and sleep parameters, as reflected by exploratory wearable measures including heart rate variability?",[68,69],"Perimenopause","Menopausal Complaints",[22],"2026-06-24",{"date":73,"type":74},"2026-06-29","ACTUAL",{"date":76,"type":62},"2026-07-15",{"date":78,"type":62},"2027-03-01",{"name":5,"class":6},1]