[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621657":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":31,"locations":40,"responsibleParty":67,"collaborators":70,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":76,"sex":82,"minAge":83,"maxAge":23,"enrollmentInfo":84,"targetDuration":23,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":96,"overallStatus":107,"whyStopped":23,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},{"fullName":5,"class":6},"University of Pittsburgh","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Comprehensive medication management with PGx testing results","EXPERIMENTAL","Participants will have a study visit with a community pharmacist for comprehensive medication management with review of PGx testing results.",[13],"Other: Comprehensive medication management with PGx testing results",{"label":15,"type":6,"description":16,"interventionNames":17},"Usual care","Participants will receive no study intervention (usual care) and will have a comprehensive medication management with review of PGx testing results at the end of the study.",[18],"Other: Usual Care",[20,24],{"type":6,"name":9,"description":21,"armGroupLabels":22,"otherNames":23},"A comprehensive medication management with PGx testing includes a pharmacist-provided review of health history, past\u002Fcurrent medications, and assessment of potential medication related problems. A review of PGx testing results will be integrated to identify any PGx-related medication issues. Recommendations will then be made to study participants' providers (regular care team) for any decisions regarding potential therapy changes.",[9],null,{"type":6,"name":25,"description":16,"armGroupLabels":26,"otherNames":23},"Usual Care",[15],[28],{"name":29,"affiliation":5,"role":30},"Philip E Empey, PharmD, PhD","PRINCIPAL_INVESTIGATOR",[32,37],{"name":33,"role":34,"phone":35,"phoneExt":23,"email":36},"Linda Prebehalla, RN","CONTACT","(412) 624-8129","CompassPGx@pitt.edu",{"name":29,"role":34,"phone":38,"phoneExt":23,"email":39},"(412) 624-7219","compasspgx@pitt.edu",[41],{"facility":5,"status":23,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Pittsburgh","Pennsylvania","15260","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-79.99589,40.44062,{"lat":51,"lon":50},[54,56,60,63,65],{"name":29,"role":34,"phone":55,"phoneExt":23,"email":36},"(412) 648-7219",{"name":57,"role":34,"phone":58,"phoneExt":23,"email":59},"Rhianna Ericson, MPH","(412) 624-8679","CompassPGxx@pitt.edu",{"name":61,"role":62,"phone":23,"phoneExt":23,"email":23},"Mylynda Massart, MD, PhD","SUB_INVESTIGATOR",{"name":64,"role":62,"phone":23,"phoneExt":23,"email":23},"Kim Coley, PharmD",{"name":66,"role":62,"phone":23,"phoneExt":23,"email":23},"Lucas Berenbrok, PharmD, MS",{"type":30,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"Philip Empey","Associate Professor",[71],{"name":72,"class":73},"Pennsylvania Department of Health","OTHER_GOV","100621657","an-evaluation-of-the-impact-of-pharmacist-comprehensive-medication-management-with-pharmacogenomic-results-to-improve-depression-outcomes-in-community-pharmacies-100621657",false,"NCT07373470","An Evaluation of the Impact of Pharmacist Comprehensive Medication Management With Pharmacogenomic Results to Improve Depression Outcomes in Community Pharmacies.","Genotype-guided Comprehensive Medication Management to Improve Depression Outcomes in Pennsylvania","COMPASS-PGx","INCLUSION CRITERIA:\n\n* At targeted community pharmacy for:\n\n  * New prescription or change in dose\u002Fschedule of SSRI (citalopram, escitalopram, sertraline, paroxetine), OR\n  * Concurrent SSRI (citalopram, escitalopram, sertraline, paroxetine) and new prescription\u002Fchange in SNRI (desvenlafaxine, duloxetine, and venlafaxine) \u002F bupropion.\n* Depressive symptoms confirmed by PHQ8 assessment (\\>5 indicating at least mild depressive symptoms)\n* UPMC patient (or able\u002Fwilling to become one) and has UPMC provider (or able\u002Fwilling to obtain one)\n* Signed consent to join Pitt+Me Discovery biobanking research study.\n* English-speaking\n\nEXCLUSION CRITERIA:\n\n* Inability to receive CMM at specific pharmacy\u002Fpharmacist\n* Comorbid diagnosis of schizophrenia (patient-reported)\n* Untreated sleep disorder (patient-reported)\n* Pitt+Me Discovery participant who has elected to not receive return of results, or who has already received results previously","ALL","18 Years",{"count":85,"type":86},220,"ESTIMATED","INTERVENTIONAL",[89],"NA","The goal of this prospective, randomized clinical trial is to learn whether pharmacogenomic (PGx)-guided comprehensive medication management delivered by pharmacists in community pharmacies will improve antidepressant treatment outcomes.\n\nThe primary aim is to determine whether comprehensive medication management with review of PGx testing results improves depression symptoms, compared with usual care.\n\nParticipants 18 years of age or older who have undergone PGx testing (e.g. through an independent biobanking study (Pitt+Me Discovery) who require initiation or adjustment of antidepressant therapy will be randomly assigned to receive either PGx-guided comprehensive medication management or usual care. Those who receive usual care will receive their PGx results at the end of the study. Researchers will compare the groups to assess whether PGx-guided care provided in partnership with community pharmacists and prescribers results in better depression and medication outcomes.",[92,93,94,95],"Pharmacogenetics","Depression - Major Depressive Disorder","Pharmacogenomic Drug Interaction","Community Pharmacy Services",[97,98,99,100,101,102,103,104,105,106],"precision medicine","pharmacogenomics","PGx","Comprehensive medication management","pharmacist","community pharmacy","medication review","antidepressants","pharmacogenomic testing","management of depression","NOT_YET_RECRUITING","2026-04-06",{"date":110,"type":111},"2026-04-08","ACTUAL",{"date":113,"type":86},"2026-04",{"date":115,"type":86},"2026-12-31",{"name":5,"class":6},1]