[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100053337":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":29,"locations":37,"responsibleParty":54,"collaborators":18,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":18,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":18,"enrollmentInfo":65,"targetDuration":18,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":82,"whyStopped":18,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Sheffield Hallam University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention","EXPERIMENTAL","Participants receive a 12-week co-produced, remotely supervised, low-intensity and low-impact exercise-based lifestyle intervention, tailored to individual capacity, with weekly remote monitoring.",[13],"Behavioral: Co-designed exercise-based lifestyle intervention",{"label":15,"type":16,"description":17,"interventionNames":18},"Usual Care","NO_INTERVENTION","Participants continue standard NHS medical care and any lifestyle advice from their treating clinicians, with no study intervention.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"BEHAVIORAL","Co-designed exercise-based lifestyle intervention","A 12-week individually tailored exercise-based lifestyle programme, co-produced with people with vEDS, delivered remotely with supervision and weekly monitoring. Comprises low-intensity, low-impact aerobic and functional activity progressed to individual capacity, with behavioural support to encourage sustained physical activity.",[9],[26],{"name":27,"affiliation":5,"role":28},"Markos Klonizakis","PRINCIPAL_INVESTIGATOR",[30,35],{"name":31,"role":32,"phone":33,"phoneExt":18,"email":34},"Ian Thistlewood","CONTACT","+447939953194","i.thistlewood@shu.ac.uk",{"name":27,"role":32,"phone":18,"phoneExt":18,"email":36},"m.klonizakis@shu.ac.uk",[38],{"facility":5,"status":18,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Sheffield","South Yorkshire","S10 2BP","United Kingdom","UK",{"type":45,"coordinates":46},"Point",[47,48],-1.4659,53.38297,{"lat":48,"lon":47},[51,53],{"name":31,"role":32,"phone":52,"phoneExt":18,"email":34},"07939953194",{"name":27,"role":32,"phone":18,"phoneExt":18,"email":36},{"type":28,"investigatorFullName":27,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Professor","100053337","an-exercise-and-lifestyle-programme-for-adults-with-vascular-ehlers-danlos-syndrome-a-feasibility-study-100053337",false,"NCT07697573","An Exercise and Lifestyle Programme for Adults With Vascular Ehlers-Danlos Syndrome: A Feasibility Study","Co-Producing and Piloting an Exercise-Based Lifestyle Intervention for Individuals With Vascular Ehlers-Danlos Syndrome (vEDS): A Mixed-Methods Feasibility Study","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Confirmed diagnosis of vascular Ehlers-Danlos syndrome (vEDS)\n* Living in the UK\n* Able to provide informed consent\n* Medically stable, defined as: no arterial dissection, rupture, or other major vEDS-related vascular event within the preceding 6 months; no recent hospitalisation for vEDS complications; and blood pressure considered controlled by their treating clinician\n* Medical clearance from their treating clinician\n* Not pregnant at the time of enrolment\n\nExclusion Criteria:\n\n* Major vEDS-related vascular event (arterial dissection or rupture) within the previous 6 months\n* Recent hospitalisation for vEDS complications\n* Blood pressure not controlled by treating clinician\n* Pregnancy at enrolment (participants who become pregnant during the intervention are withdrawn from the exercise component but may continue follow-up data collection if they wish)\n* Unable to provide informed consent","ALL","18 Years",{"count":66,"type":67},40,"ESTIMATED","INTERVENTIONAL",[70],"NA","Vascular Ehlers-Danlos syndrome (vEDS) is a rare, life-threatening connective tissue disorder. People with vEDS have often been advised to limit physical activity, yet the safety and feasibility of structured exercise in this group is poorly understood. This study works with people with vEDS, their families and clinicians to co-design a safe, tailored physical activity programme, then tests it in a 12-week randomised feasibility study comparing the programme with usual care. The aim is to find out whether the intervention and the trial procedures are safe, acceptable and practical, in order to inform a future full-scale trial. Outcomes focus on recruitment, retention, adherence, acceptability and safety, alongside exploratory measures of physical function, quality of life and microvascular health.",[73],"Vascular Ehlers Danlos Syndrome",[75,76,77,78,79,80,81],"vEDS","COL3A1","physical activity","exercise","feasibility study","rare disease","connective tissue disorder","NOT_YET_RECRUITING","2026-07-09",{"date":85,"type":86},"2026-07-13","ACTUAL",{"date":88,"type":67},"2027-03-01",{"date":90,"type":67},"2028-03-17",{"name":5,"class":6},1]