[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641010":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":29,"locations":38,"responsibleParty":352,"collaborators":356,"id":359,"slug":360,"hasResults":361,"nctId":362,"briefTitle":363,"officialTitle":364,"acronym":365,"eligibilityCriteria":366,"healthyVolunteers":361,"sex":367,"minAge":10,"maxAge":10,"enrollmentInfo":368,"targetDuration":371,"studyType":372,"phases":10,"briefSummary":373,"conditions":374,"keywords":377,"overallStatus":386,"whyStopped":10,"lastUpdateSubmitDate":387,"lastUpdatePostDateStruct":388,"startDateStruct":391,"completionDateStruct":393,"leadSponsor":395,"locationsCount":396},{"fullName":5,"class":6},"Centre Hospitalier Universitaire Vaudois","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients with congenital heart disease",null,"FAST-CMR will evaluate the technique's performance in complex, heterogeneous anatomy.",{"label":13,"type":10,"description":14,"interventionNames":10},"Patients unable to perform breath-holding","including those with advanced heart failure, pulmonary hypertension, or chronic obstructive pulmonary disease (COPD), representing a subgroup where conventional breath-held CMR techniques are often suboptimal or not feasible.",{"label":16,"type":10,"description":17,"interventionNames":10},"Other cardiovascular disease patients who are able to perform breath-holding","This group represents the standard patient population for whom conventional CMR is currently optimized.",[19,23,26],{"name":20,"affiliation":21,"role":22},"Matthias Stuber, PhD","CHUV","PRINCIPAL_INVESTIGATOR",{"name":24,"affiliation":25,"role":22},"Tim Leiner, MD, PhD","Mayo Clinic",{"name":27,"affiliation":28,"role":22},"Kim-Lien Nguyen, MD","University of California, Los Angeles",[30,35],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},"Katerina Eyre, PhD","CONTACT","+41213147513","katerina.eyre@chuv.ch",{"name":20,"role":32,"phone":36,"phoneExt":10,"email":37},"+41213147534","matthias.stuber@chuv.ch",[39,55,70,85,100,113,128,143,158,173,190,207,224,238,253,270,287,304,319,336],{"facility":28,"status":10,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Los Angeles","California","90095","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-118.24368,34.05223,{"lat":49,"lon":48},[52],{"name":27,"role":32,"phone":53,"phoneExt":10,"email":54},"+1 (310) 825-1234","KimLienNguyen@mednet.ucla.edu",{"facility":56,"status":10,"city":57,"state":58,"zip":59,"country":43,"countryCode":44,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"Emory University","Atlanta","Georgia","30322",{"type":46,"coordinates":61},[62,63],-84.38798,33.749,{"lat":63,"lon":62},[66],{"name":67,"role":32,"phone":68,"phoneExt":10,"email":69},"John Oshinski, PhD","+1 404-727-5894","jnoshin@emory.edu",{"facility":71,"status":10,"city":72,"state":73,"zip":74,"country":43,"countryCode":44,"cosmosGeoPoint":75,"geoPoint":79,"contacts":80},"Ann & Robert H Lurie Children's Hospital of Chicago","Chicago","Illinois","60611",{"type":46,"coordinates":76},[77,78],-87.65005,41.85003,{"lat":78,"lon":77},[81],{"name":82,"role":32,"phone":83,"phoneExt":10,"email":84},"Joshua D. Robinson, MD","+1 312-227-4638","jdrobinson@luriechildrens.org",{"facility":86,"status":10,"city":87,"state":88,"zip":89,"country":43,"countryCode":44,"cosmosGeoPoint":90,"geoPoint":94,"contacts":95},"Boston's Children Hospital","Boston","Massachusetts","02115",{"type":46,"coordinates":91},[92,93],-71.05977,42.35843,{"lat":93,"lon":92},[96],{"name":97,"role":32,"phone":98,"phoneExt":10,"email":99},"Andrew Powell, MD","+1 617-355-2079","andrew.powell@cardio.chboston.org",{"facility":25,"status":10,"city":101,"state":102,"zip":103,"country":43,"countryCode":44,"cosmosGeoPoint":104,"geoPoint":108,"contacts":109},"Rochester","Minnesota","55902",{"type":46,"coordinates":105},[106,107],-92.4699,44.02163,{"lat":107,"lon":106},[110],{"name":24,"role":32,"phone":111,"phoneExt":10,"email":112},"+1 507-284-2511","leiner.tim@mayo.edu",{"facility":114,"status":10,"city":115,"state":116,"zip":117,"country":43,"countryCode":44,"cosmosGeoPoint":118,"geoPoint":122,"contacts":123},"Washington University in St. Louis","St Louis","Missouri","63130",{"type":46,"coordinates":119},[120,121],-90.19789,38.62727,{"lat":121,"lon":120},[124],{"name":125,"role":32,"phone":126,"phoneExt":10,"email":127},"Pamela Woodard, MD","+1 314-747-3386","woodardp@nospam.wustl.edu",{"facility":129,"status":10,"city":130,"state":131,"zip":132,"country":43,"countryCode":44,"cosmosGeoPoint":133,"geoPoint":137,"contacts":138},"Ohio State University","Columbus","Ohio","43210",{"type":46,"coordinates":134},[135,136],-82.99879,39.96118,{"lat":136,"lon":135},[139],{"name":140,"role":32,"phone":141,"phoneExt":10,"email":142},"Yuchi Han, MD","+1 614-292-6446","yuchi.han@osumc.edu",{"facility":144,"status":10,"city":145,"state":146,"zip":147,"country":43,"countryCode":44,"cosmosGeoPoint":148,"geoPoint":152,"contacts":153},"Children's Hospital of Philadelphia","Philadelphia","Pennsylvania","19104",{"type":46,"coordinates":149},[150,151],-75.16362,39.95238,{"lat":151,"lon":150},[154],{"name":155,"role":32,"phone":156,"phoneExt":10,"email":157},"Mark Fogel, MD","+1 215-590-3534","fogel@email.chop.edu",{"facility":159,"status":10,"city":160,"state":161,"zip":162,"country":43,"countryCode":44,"cosmosGeoPoint":163,"geoPoint":167,"contacts":168},"UT Southwestern Medical Center","Dallas","Texas","75390",{"type":46,"coordinates":164},[165,166],-96.80667,32.78306,{"lat":166,"lon":165},[169],{"name":170,"role":32,"phone":171,"phoneExt":10,"email":172},"Franz Gerald Greil, MD, PhD","+1 214-648-3111","gerald.greil@utsouthwestern.edu",{"facility":174,"status":10,"city":175,"state":176,"zip":177,"country":178,"countryCode":179,"cosmosGeoPoint":180,"geoPoint":184,"contacts":185},"University of Melbourne","Melbourne","Victoria","3010","Australia","AU",{"type":46,"coordinates":181},[182,183],144.96332,-37.814,{"lat":183,"lon":182},[186],{"name":187,"role":32,"phone":188,"phoneExt":10,"email":189},"Ruth Lim, MD","+61 3 9035 5511","ruthplim74@gmail.com",{"facility":191,"status":10,"city":192,"state":193,"zip":194,"country":195,"countryCode":196,"cosmosGeoPoint":197,"geoPoint":201,"contacts":202},"Fundacion Cardioinfantil-LaCardio","Bogotá","Capital District","111156","Colombia","CO",{"type":46,"coordinates":198},[199,200],-74.08175,4.60971,{"lat":200,"lon":199},[203],{"name":204,"role":32,"phone":205,"phoneExt":10,"email":206},"Carlos Guerrero, MD","+57 (601) 744 2000","ceguerrero@lacardio.org",{"facility":208,"status":10,"city":209,"state":210,"zip":211,"country":212,"countryCode":213,"cosmosGeoPoint":214,"geoPoint":218,"contacts":219},"University of Bonn","Bonn","North Rhine-Westphalia","53113","Germany","DE",{"type":46,"coordinates":215},[216,217],7.09549,50.73438,{"lat":217,"lon":216},[220],{"name":221,"role":32,"phone":222,"phoneExt":10,"email":223},"Julian Luetkens, MD, PhD","+49 228 287 19860","Julian.Luetkens@ukbonn.de",{"facility":225,"status":10,"city":226,"state":210,"zip":227,"country":212,"countryCode":213,"cosmosGeoPoint":228,"geoPoint":232,"contacts":233},"Cologne University Medical Center","Cologne","50931",{"type":46,"coordinates":229},[230,231],6.95,50.93333,{"lat":231,"lon":230},[234],{"name":235,"role":32,"phone":236,"phoneExt":10,"email":237},"David Maintz, MD, PhD","+49 221 478-82035","david.maintz@uk-koeln.de",{"facility":239,"status":10,"city":240,"state":241,"zip":242,"country":212,"countryCode":213,"cosmosGeoPoint":243,"geoPoint":247,"contacts":248},"Charité - Universitätsmedizin Berlin","Berlin","State of Berlin","10117",{"type":46,"coordinates":244},[245,246],13.41053,52.52437,{"lat":246,"lon":245},[249],{"name":250,"role":32,"phone":251,"phoneExt":10,"email":252},"Sebastian Kelle, MD, PhD","+493045931182","sebastian.kelle@dhzc-charite.de",{"facility":254,"status":10,"city":255,"state":256,"zip":257,"country":258,"countryCode":259,"cosmosGeoPoint":260,"geoPoint":264,"contacts":265},"Università Cattolica - Fondazione Policlinico Gemelli IRCCS","Rome","Lazio","00168","Italy","IT",{"type":46,"coordinates":261},[262,263],12.51133,41.89193,{"lat":263,"lon":262},[266],{"name":267,"role":32,"phone":268,"phoneExt":10,"email":269},"Luigi Natale, MD","+971 56 666 0984","luigi.natale@unicatt.it",{"facility":271,"status":10,"city":272,"state":273,"zip":274,"country":275,"countryCode":276,"cosmosGeoPoint":277,"geoPoint":281,"contacts":282},"Mie University","Tsu","Mie-ken","514-8507","Japan","JP",{"type":46,"coordinates":278},[279,280],136.51667,34.73333,{"lat":280,"lon":279},[283],{"name":284,"role":32,"phone":285,"phoneExt":10,"email":286},"Hajime Sakuma, MD, PhD","+81 59 231 5029","sakuma@med.mie-u.ac.jp",{"facility":288,"status":10,"city":289,"state":290,"zip":291,"country":292,"countryCode":293,"cosmosGeoPoint":294,"geoPoint":298,"contacts":299},"Maastricht University Medical Center","Maastricht","Limburg","6229 HX","Netherlands","NL",{"type":46,"coordinates":295},[296,297],5.68889,50.84833,{"lat":297,"lon":296},[300],{"name":301,"role":32,"phone":302,"phoneExt":10,"email":303},"Robert J. Holtackers, PhD","+31 43 387 49 10","rob.holtackers@mumc.nl",{"facility":305,"status":10,"city":306,"state":306,"zip":307,"country":306,"countryCode":308,"cosmosGeoPoint":309,"geoPoint":313,"contacts":314},"National University of Singapore","Singapore","119275","SG",{"type":46,"coordinates":310},[311,312],103.85007,1.28967,{"lat":312,"lon":311},[315],{"name":316,"role":32,"phone":317,"phoneExt":10,"email":318},"Liang Zhong, PhD","+65 67042237","gmszl@nus.edu.sg",{"facility":320,"status":10,"city":321,"state":322,"zip":323,"country":324,"countryCode":325,"cosmosGeoPoint":326,"geoPoint":330,"contacts":331},"University of Cape Town","Cape Town","Western Cape","7700","South Africa","ZA",{"type":46,"coordinates":327},[328,329],18.42322,-33.92584,{"lat":329,"lon":328},[332],{"name":333,"role":32,"phone":334,"phoneExt":10,"email":335},"Ntobeko Ntusi, MD, PhD","+27 21 406 6358","ntobeko.ntusi@uct.ac.za",{"facility":337,"status":10,"city":338,"state":338,"zip":339,"country":340,"countryCode":341,"cosmosGeoPoint":342,"geoPoint":346,"contacts":347},"King's College London","London","WC2R2LS","United Kingdom","UK",{"type":46,"coordinates":343},[344,345],-0.12574,51.50853,{"lat":345,"lon":344},[348],{"name":349,"role":32,"phone":350,"phoneExt":10,"email":351},"Amedeo Chiribiri, MD, PhD","+44 20 7188 8259","amedeo.chiribiri@kcl.ac.uk",{"type":353,"investigatorFullName":354,"investigatorTitle":355,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Matthias Stuber","Professor and Section Head CIBM MRI CHUV-UNIL",[357,358],{"name":25,"class":6},{"name":28,"class":6},"100641010","an-international-multicenter-multivendor-evaluation-of-the-free-running-framework-for-cardiac-function-100641010",false,"NCT07613398","An International Multicenter, Multivendor Evaluation of the Free-Running Framework for Cardiac Function","Assessment and Validation of the Established Free-Running Framework for Cardiac Function by Magnetic Resonance Imaging (FAST-CMR): An International Multi-Center, Multi-Vendor Study at 1.5T","FAST-CMR","Inclusion Criteria:\n\n* Diagnosed with cardiac disease of any complexity and scheduled for a clinical cardiac MRI on a clinical 1.5T MRI scanner\n* Able to understand and provide written informed consent or, for minors, ability to provide assent with written consent from a parent\u002Flegal representative, per local law and site policy prior to the study\n* Ability to undergo MRI without contraindications\n* Agrees to be informed in the event of incidental findings\n\nExclusion Criteria:\n\n* Severe claustrophobia preventing MRI completion\n* Presence of non-MRI compatible implants (e.g., pacemakers, certain metallic implants)\n* Contraindications to the intravenous contrast agent\n* Movement disorders or inability to remain still during the scan","ALL",{"count":369,"type":370},300,"ESTIMATED","1 Day","OBSERVATIONAL","This project aims to evaluate a new cardiac MRI technique called the Free-Running Framework (FRF), which could simplify and accelerate the process of acquiring cardiac images. The investigators want to verify whether this method can provide functional heart measurements comparable to those obtained with traditional methods. More specifically, the goal of the study is to compare the measurements obtained with FRF to those obtained with standard sequences, to ensure they match and that this new approach can be reliably used in clinical practice. The FRF technique works differently from standard cardiac MRI. In standard exams, patients are asked to hold their breath several times and small electrodes (ECG) are used to monitor the heartbeat during the scan. These steps are needed to get clearer images of the heart as it moves. With FRF, these steps are no longer necessary: the scan is performed while patients' breath normally and without ECG monitoring. In addition, standard MRI takes multiple 2D slices of the heart, one after another. The FRF method instead captures a 3D image of the entire heart in one go, which can improve the consistency of the exam and reduce errors when doctors analyze the images later. This is all possible because the FRF method records data continuously and then organizes the images afterward based on how participants heart and breathing were moving during the exam. This helps the imager to get clear images of the heart, even without breath-holding or ECG monitoring. This project is aimed at individuals with heart disease who require cardiac MRI exams to monitor their health status (age ≥ 18 years) and are able to clearly understand the instructions provided by the research team. The investigators have already conducted small-scale technical and feasibility studies using FRF. These studies have shown that FRF is easy to use, faster than traditional methods, and provides image quality comparable to standard imaging techniques. The investigators now wish to evaluate its use in a clinical setting. More specifically, the investigators need to verify that FRF provides the same essential diagnostic information as standard techniques, so that it can be reliably used in future patient care. A maximum of 300 participants will be included in the investigation of this MRI technique between 2026 and 2031. This is a multi-center study, conducted internationally across 18 centers.\n\nThis project is being carried out in compliance with Swiss legislation. The investigators follow all internationally recognized guidelines. The competent ethics committee has reviewed and approved this project.",[375,376],"Congenital Heart Diseases","Cardiac Diseases",[378,379,380,381,382,383,384,385],"Free-running","Cine magnetic resonance imaging","Ventricular function","Multicenter","Multivendor","FISS (Fast- Interrupted Steady-State)","Compressed sensing","Pragmatic clinical study","NOT_YET_RECRUITING","2026-05-21",{"date":389,"type":390},"2026-05-29","ACTUAL",{"date":392,"type":370},"2026-06",{"date":394,"type":370},"2030-09",{"name":354,"class":6},20]