[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100371178":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":13,"centralContacts":18,"locations":28,"responsibleParty":325,"collaborators":7,"id":327,"slug":328,"hasResults":329,"nctId":330,"briefTitle":331,"officialTitle":332,"acronym":7,"eligibilityCriteria":333,"healthyVolunteers":329,"sex":334,"minAge":335,"maxAge":7,"enrollmentInfo":336,"targetDuration":339,"studyType":340,"phases":7,"briefSummary":341,"conditions":342,"keywords":345,"overallStatus":31,"whyStopped":7,"lastUpdateSubmitDate":347,"lastUpdatePostDateStruct":348,"startDateStruct":351,"completionDateStruct":353,"leadSponsor":355,"locationsCount":356},{"fullName":5,"class":6},"AO Innovation Translation Center","OTHER",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"PROCEDURE","Any treatment that is used for a defect of any long bone","Any treatment that is used for a defect of any long bone. All treatments are based on individual clinician's judgement and the patient characteristics. The registry does not dictate any specific treatment.",[14],{"name":15,"affiliation":16,"role":17},"Hans-Christoph Pape, MD","University Hospital Zurich Department of Trauma Surgery","PRINCIPAL_INVESTIGATOR",[19,24],{"name":20,"role":21,"phone":22,"phoneExt":7,"email":23},"Marco Minoia","CONTACT","+41 79 612 09 67","marco.minoia@aofoundation.org",{"name":25,"role":21,"phone":26,"phoneExt":7,"email":27},"Joelle Kägi","+41 79 549 32 83","joelle.kaegi@aofoundation.org",[29,47,60,75,90,105,117,129,143,156,165,177,193,208,223,236,251,264,278,293,307],{"facility":30,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Cedar Sinai","RECRUITING","Los Angeles","California","90048","United States","US",{"type":38,"coordinates":39},"Point",[40,41],-118.24368,34.05223,{"lat":41,"lon":40},[44],{"name":45,"role":21,"phone":7,"phoneExt":7,"email":46},"Geoffrey Marecek, MD","Geoffrey.Marecek@cshs.org",{"facility":48,"status":31,"city":49,"state":50,"zip":51,"country":35,"countryCode":36,"cosmosGeoPoint":52,"geoPoint":56,"contacts":57},"Sinai Hospital of Baltimore","Baltimore","Maryland","21215",{"type":38,"coordinates":53},[54,55],-76.61219,39.29038,{"lat":55,"lon":54},[58],{"name":59,"role":21,"phone":7,"phoneExt":7,"email":7},"Janet Conway",{"facility":61,"status":31,"city":62,"state":7,"zip":63,"country":64,"countryCode":65,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"John Hunter Hospital","Newcastle","2310","Australia","AU",{"type":38,"coordinates":67},[68,69],151.7801,-32.92953,{"lat":69,"lon":68},[72],{"name":73,"role":21,"phone":7,"phoneExt":7,"email":74},"Zsolt Balogh, Prof Dr Dr","zsolt.balogh@hnehealth.nsw.gov.au",{"facility":76,"status":31,"city":77,"state":7,"zip":78,"country":79,"countryCode":80,"cosmosGeoPoint":81,"geoPoint":85,"contacts":86},"Hospital Municipal Miguel Couto Serviço de Ortopedia e Traumatologia","Rio de Janeiro","22430-160","Brazil","BR",{"type":38,"coordinates":82},[83,84],-43.18223,-22.90642,{"lat":84,"lon":83},[87],{"name":88,"role":21,"phone":7,"phoneExt":7,"email":89},"Vincenzo Giordano, MD","v_giordano@me.com",{"facility":91,"status":31,"city":92,"state":7,"zip":93,"country":94,"countryCode":95,"cosmosGeoPoint":96,"geoPoint":100,"contacts":101},"Hospital Base Valdivia","Valdivia","5090146","Chile","CL",{"type":38,"coordinates":97},[98,99],-73.24589,-39.81422,{"lat":99,"lon":98},[102],{"name":103,"role":21,"phone":7,"phoneExt":7,"email":104},"Matías Sepulveda, Dr","contacto@matiassepulveda.com",{"facility":106,"status":107,"city":108,"state":7,"zip":109,"country":110,"countryCode":111,"cosmosGeoPoint":112,"geoPoint":116,"contacts":7},"Hospital Universitario de la Samaritana","SUSPENDED","Bogotá","110411","Colombia","CO",{"type":38,"coordinates":113},[114,115],-74.08175,4.60971,{"lat":115,"lon":114},{"facility":118,"status":31,"city":119,"state":7,"zip":7,"country":110,"countryCode":111,"cosmosGeoPoint":120,"geoPoint":124,"contacts":125},"Hospital Pablo Tobon Uribe","Medellín",{"type":38,"coordinates":121},[122,123],-75.57151,6.245,{"lat":123,"lon":122},[126],{"name":127,"role":21,"phone":7,"phoneExt":7,"email":128},"Carlos Oliver Valderrama-Molina, MD","cvalderrama@hptu.org.co",{"facility":130,"status":31,"city":131,"state":7,"zip":7,"country":132,"countryCode":133,"cosmosGeoPoint":134,"geoPoint":138,"contacts":139},"University Hospital Frankfurt","Frankfurt","Germany","DE",{"type":38,"coordinates":135},[136,137],10.53333,49.68333,{"lat":137,"lon":136},[140],{"name":141,"role":21,"phone":7,"phoneExt":7,"email":142},"Ingo Marzi, MD","marzi@trauma.uni-frankfurt.de",{"facility":144,"status":31,"city":145,"state":7,"zip":146,"country":132,"countryCode":133,"cosmosGeoPoint":147,"geoPoint":151,"contacts":152},"Universitätsspital Gießen","Giessen","35385",{"type":38,"coordinates":148},[149,150],8.67554,50.58727,{"lat":150,"lon":149},[153],{"name":154,"role":21,"phone":7,"phoneExt":7,"email":155},"Christian Heiss, Prof Dr Dr","christian.heiss@chiru.med.uni-giessen.de",{"facility":157,"status":158,"city":159,"state":7,"zip":7,"country":132,"countryCode":133,"cosmosGeoPoint":160,"geoPoint":164,"contacts":7},"Universitätsklinikum Heidelberg (Unfallchirurgie)","TERMINATED","Heidelberg",{"type":38,"coordinates":161},[162,163],8.69079,49.40768,{"lat":163,"lon":162},{"facility":166,"status":31,"city":167,"state":7,"zip":7,"country":132,"countryCode":133,"cosmosGeoPoint":168,"geoPoint":172,"contacts":173},"Universitätsklinikum Münster (Klinik und Poliklinik für Unfall-, Hand- und Wiederherstellungschirurgie)","Münster",{"type":38,"coordinates":169},[170,171],7.62571,51.96236,{"lat":171,"lon":170},[174],{"name":175,"role":21,"phone":7,"phoneExt":7,"email":176},"Steffen Rosslenbroich, MD","Steffen.Rosslenbroich@ukmuenster.de",{"facility":178,"status":179,"city":180,"state":7,"zip":181,"country":132,"countryCode":133,"cosmosGeoPoint":182,"geoPoint":186,"contacts":187},"Krankenhaus Johanneum","NOT_YET_RECRUITING","Wildeshausen","27793",{"type":38,"coordinates":183},[184,185],8.43375,52.89446,{"lat":185,"lon":184},[188,192],{"name":189,"role":21,"phone":190,"phoneExt":7,"email":191},"Ahmed Yaseen","+4917671973159","Yaseen.Ahmed@krankenhaus-johanneum.de",{"name":189,"role":17,"phone":7,"phoneExt":7,"email":7},{"facility":194,"status":31,"city":195,"state":7,"zip":196,"country":197,"countryCode":198,"cosmosGeoPoint":199,"geoPoint":203,"contacts":204},"Paras HMRI Hospital Patna","Patna","800014","India","IN",{"type":38,"coordinates":200},[201,202],85.13563,25.59408,{"lat":202,"lon":201},[205],{"name":206,"role":21,"phone":7,"phoneExt":7,"email":207},"John Mukhopadhaya, MD","mukhoj@gmail.com",{"facility":209,"status":31,"city":210,"state":7,"zip":7,"country":211,"countryCode":212,"cosmosGeoPoint":213,"geoPoint":217,"contacts":218},"Academisch Ziekenhuis Maastricht (Dept. of Surgery)","Maastricht","Netherlands","NL",{"type":38,"coordinates":214},[215,216],5.68889,50.84833,{"lat":216,"lon":215},[219],{"name":220,"role":21,"phone":221,"phoneExt":7,"email":222},"Martijn Poeze, MD","+31433871956","m.poeze@mumc.nl",{"facility":224,"status":31,"city":225,"state":7,"zip":226,"country":211,"countryCode":212,"cosmosGeoPoint":227,"geoPoint":231,"contacts":232},"Radboud University Medical Center","Nijmegen","6525",{"type":38,"coordinates":228},[229,230],5.85278,51.8425,{"lat":230,"lon":229},[233],{"name":234,"role":21,"phone":7,"phoneExt":7,"email":235},"Michael Edwards, MD","michael.edwards@radboudumc.nl",{"facility":237,"status":179,"city":238,"state":7,"zip":239,"country":240,"countryCode":241,"cosmosGeoPoint":242,"geoPoint":246,"contacts":247},"Tygerberg Hospital","Cape Town","7505","South Africa","ZA",{"type":38,"coordinates":243},[244,245],18.42322,-33.92584,{"lat":245,"lon":244},[248],{"name":249,"role":21,"phone":7,"phoneExt":7,"email":250},"Nando Ferreira","NFERREIRA@sun.ac.za",{"facility":252,"status":31,"city":253,"state":7,"zip":7,"country":254,"countryCode":7,"cosmosGeoPoint":255,"geoPoint":259,"contacts":260},"Kyungpook National University Hospital (Orthopaedics)","Daegu","South Korea",{"type":38,"coordinates":256},[257,258],128.59111,35.87028,{"lat":258,"lon":257},[261],{"name":262,"role":21,"phone":7,"phoneExt":7,"email":263},"Chang-Wug Oh, MD","cwoh@knu.ac.kr",{"facility":265,"status":31,"city":266,"state":7,"zip":7,"country":267,"countryCode":268,"cosmosGeoPoint":269,"geoPoint":273,"contacts":274},"Universitätsspital Zürich (Klinik für Traumatologie)","Zurich","Switzerland","CH",{"type":38,"coordinates":270},[271,272],8.55,47.36667,{"lat":272,"lon":271},[275],{"name":15,"role":21,"phone":276,"phoneExt":7,"email":277},"+ 41 (0)44 255 27 55","Hans-Christoph.Pape@usz.ch",{"facility":279,"status":179,"city":280,"state":7,"zip":7,"country":281,"countryCode":282,"cosmosGeoPoint":283,"geoPoint":287,"contacts":288},"Central Hospital of Border Guard Service of Ukraine","Kyiv","Ukraine","UA",{"type":38,"coordinates":284},[285,286],30.5238,50.45466,{"lat":286,"lon":285},[289,292],{"name":290,"role":21,"phone":7,"phoneExt":7,"email":291},"Dmytro Smolianets","smolianets.dmytro@gmail.com",{"name":290,"role":17,"phone":7,"phoneExt":7,"email":7},{"facility":294,"status":179,"city":295,"state":7,"zip":7,"country":296,"countryCode":297,"cosmosGeoPoint":298,"geoPoint":302,"contacts":303},"Leeds General Infirmary University Hospital (Trauma & Orthopaedic Surgery)","Leeds","United Kingdom","UK",{"type":38,"coordinates":299},[300,301],-1.54785,53.79648,{"lat":301,"lon":300},[304],{"name":305,"role":21,"phone":7,"phoneExt":7,"email":306},"Peter Giannoudis, MD","peter.giannoudis@nhs.net",{"facility":308,"status":179,"city":309,"state":7,"zip":7,"country":310,"countryCode":7,"cosmosGeoPoint":311,"geoPoint":315,"contacts":316},"Hospital Universitario de Caracas","Caracas","Venezuela",{"type":38,"coordinates":312},[313,314],-66.87919,10.48801,{"lat":314,"lon":313},[317,321,322],{"name":318,"role":21,"phone":319,"phoneExt":7,"email":320},"Manuel Malaret","+584143119338","manuel.malaret.b@gmail.com",{"name":318,"role":17,"phone":7,"phoneExt":7,"email":7},{"name":323,"role":324,"phone":7,"phoneExt":7,"email":7},"Igor Escalante","SUB_INVESTIGATOR",{"type":326,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100371178","an-international-multicenter-prospective-registry-on-post-traumatic-long-bones-defects-100371178",false,"NCT04112992","An International, Multicenter, Prospective Registry on Post-traumatic Long Bones Defects","An International, Multicenter, Prospective Registry to Investigate Treatment Options and Their Outcomes on Post-traumatic Long Bones Defects","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Skeletally mature\n* Post traumatic bone defect \\> 2 cm either\n\n  * initially after injury or\n  * after surgical debridement\n* Informed consent obtained, i.e.:\n\n  * Ability to understand the content of the patient information\u002FICF\n  * Willingness and ability to participate in the clinical investigation according to the registry plan\n  * Signed and dated EC\u002FIRB approved written informed consent OR\n  * Written consent provided according to the IRB\u002FEC defined and approved procedures for patients who are not able to provide independent written informed consent\n\nExclusion Criteria:\n\n* Any oblique defect that has less than 8cm expansion when adding the defect size of all four cortices\n* Any not medically managed severe systemic disease\n* Pregnancy\n* Prisoners\n* Participation in any other medical device or medicinal product registry within the previous 3 months that could influence the results of the present registry","ALL","18 Years",{"count":337,"type":338},600,"ESTIMATED","1 Year","OBSERVATIONAL","Long bone defect (LBD) is defined as a focalized loss of bone tissue in any long bone of the upper or lower extremity. Long bone defects are a complex problem, that may arise as a complication of many different pathologies, such as trauma, tumors or infection. Whereas post-traumatic defects are the largest group.\n\nReports estimate that there are almost 4 million bone grafting procedures worldwide per year. However, limb reconstruction in the context of a bony defect is challenging and up to date there is little evidence and treatment recommendations.\n\nIn a multi-national approach, the aim of this project is to set up an international, multicenter registry to gather information and details on prevalence or incidence, current treatments, complications and outcome.",[343,344],"Limb Fracture","Bone Loss",[346],"long bone defect","2025-08-28",{"date":349,"type":350},"2025-08-29","ACTUAL",{"date":352,"type":350},"2024-07-03",{"date":354,"type":338},"2029-03-30",{"name":5,"class":6},21]