[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100557813":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":20,"locations":30,"responsibleParty":48,"collaborators":19,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":19,"eligibilityCriteria":57,"healthyVolunteers":54,"sex":58,"minAge":59,"maxAge":19,"enrollmentInfo":60,"targetDuration":19,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":71,"overallStatus":33,"whyStopped":19,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Anhui Medical University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"rTMS group","EXPERIMENTAL","On the basis of drug treatment, a course of TBS treatment is performed for 7 days.",[13],"Other: transcranial magnetic stimulation",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"transcranial magnetic stimulation","During treatment, the patient underwent cTBS targeting the left SMA for 7 consecutive days. Each treatment day comprised six rounds of cTBS, with a 15-minute interval between each. A single cTBS session involved trains of three pulses at 50 Hz, repeated every 200 ms (5 Hz), until reaching a total of 600 pulses, lasting 40s. Stimulation intensity remained at 80% of resting motor threshold. In total, patients received 25,200 pulses throughout the treatment period.",[9],null,[21,26],{"name":22,"role":23,"phone":24,"phoneExt":19,"email":25},"Kai Wang, Ph.D.","CONTACT","055162923704","wangkai1964@126.com",{"name":27,"role":23,"phone":28,"phoneExt":19,"email":29},"Panpan Hu, M.D.","13515602285","hpppanda9@126.com",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":19,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Cognitive Neuropsychology Lab Anhui Medical University","RECRUITING","Hefei","Anhui","China","CN",{"type":39,"coordinates":40},"Point",[41,42],117.28083,31.86389,{"lat":42,"lon":41},[45,47],{"name":22,"role":23,"phone":46,"phoneExt":19,"email":25},"+8655162923704",{"name":27,"role":23,"phone":28,"phoneExt":19,"email":29},{"type":49,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"PRINCIPAL_INVESTIGATOR","WANG KAI","Head, Dept of Neurology & Medical Psychology, Director, Cognitive Neuropsychology Lab, PRC","100557813","an-open-label-study-on-the-clinical-efficacy-of-rtms-intervention-in-pd-100557813",false,"NCT06542991","An Open-label Study on the Clinical Efficacy of rTMS Intervention in PD","Inclusion Criteria:\n\n1. Age ≥40 years old\n2. Meet Movement Disorder Society standards;\n3. Have no history of drug adjustment within 4 weeks before and during treatment;\n4. The MDS-UPDRS Ⅲ score ≥8, and the Hoehn-Yahr rating is 1-4\n5. MMSE ≥24，able to cooperate with the completion of behavioral tests and transcranial magnetic stimulation therapy.\n\nExclusion Criteria:\n\n1. Head MRI\u002FCT ruled out focal brain injury or severe leukoencephalopathy (Fazekas grade 3);\n2. Various secondary parkinsonism syndromes (vascular parkinsonism, Parkinsonism combined with parkinsonism, drug parkinsonism, etc.);\n3. Severe craniocerebral trauma, received craniocerebral surgery or deep brain stimulation treatment;\n4. There are ferromagnetic implants in the body, such as cochlear implants, cardiac pacemakers, etc.\n5. The person or first-degree relatives have a history of epilepsy, unexplained loss of consciousness, or are taking anticonvulsant drugs to treat epileptic seizures;\n6. Diagnosed with a neuropsychiatric disorder other than PD\n7. Have a history of drug abuse or drug use;\n8. Participants in any clinical trial within the previous 6 month;\n9. Pregnant\u002Flactating women or subjects (including men) who have a birth plan within 6 months;\n10. Other conditions deemed unsuitable for inclusion by the investigator.","ALL","40 Years",{"count":61,"type":62},20,"ESTIMATED","INTERVENTIONAL",[65],"NA","To demonstrate that intervention targeting the supplementary motor area (SMA) using precise navigation positioning can effectively improve motor symptoms in patients with Parkinson's disease.",[68,69,70],"Transcranial Magnetic Stimulation","Parkinson Disease","Supplementary Motor Area",[68,69,72],"Supplementary motor area","2024-08-03",{"date":75,"type":76},"2024-08-07","ACTUAL",{"date":78,"type":62},"2024-09-01",{"date":80,"type":62},"2025-03-31",{"name":5,"class":6},1]