[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100521060":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":55,"collaborators":10,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":59,"sex":65,"minAge":10,"maxAge":10,"enrollmentInfo":66,"targetDuration":10,"studyType":69,"phases":10,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":40,"whyStopped":10,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Jonsson Comprehensive Cancer Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group 1: local tumor",null,"patients with localized osteosarcoma who are scheduled to undergo diagnostic biopsy and are planned for surgical excision of the primary tumor",[13],"Other: standard of care biopsy",{"label":15,"type":10,"description":16,"interventionNames":17},"Group 2: metastatic disease","patients with metastatic osteosarcoma who are scheduled to undergo either biopsy or surgery of metastatic disease",[13],[19,23],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"standard of care biopsy","Image-guided or surgical biopsy of the lesion that is suspected to be osteosarcoma in a patient with localized disease (Group 1)",[9],{"type":6,"name":20,"description":24,"armGroupLabels":25,"otherNames":10},"Image-guided or surgical biopsy or excision of the lesion that is suspected to be recurrent or metastatic osteosarcoma (Group 2).",[15],[27],{"name":28,"affiliation":29,"role":30},"Alice Soragni, PhD","University of California at Los Angeles","PRINCIPAL_INVESTIGATOR",[32],{"name":33,"role":34,"phone":35,"phoneExt":10,"email":36},"Summer Swearingen","CONTACT","(424) 766-9349","SSwearingen@mednet.ucla.edu",[38],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"UCLA \u002F Jonsson Comprehensive Cancer Center","RECRUITING","Los Angeles","California","90095","United States","US",{"type":47,"coordinates":48},"Point",[49,50],-118.24368,34.05223,{"lat":50,"lon":49},[53],{"name":33,"role":34,"phone":54,"phoneExt":10,"email":36},"424-766-9349",{"type":56,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100521060","an-organoid-based-functional-precision-medicine-trial-in-osteosarcoma-100521060",false,"NCT06064682","An Organoid-based Functional Precision Medicine Trial in Osteosarcoma","An Organoid-based Functional Precision Medicine Trial in Osteosarcoma: PREMOST","PREMOST","Inclusion \u002F exclusion criteria - Group1:\n\n\\- Patients without diagnosis of osteosarcoma and whose imaging studies are suggestive of osteosarcoma and who are planned to undergo biopsy or surgery for diagnostic purposes\n\nInclusion \u002F exclusion criteria - Group 2:\n\n\\- Patients whose imaging studies are suggestive of metastatic osteosarcoma and who are planned to undergo biopsy or surgery for diagnostic purposes","ALL",{"count":67,"type":68},40,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to examine if we can predict sensitivity of osteosarcoma to different chemotherapy agents using tissue cultures in the laboratory. We know that different chemotherapy agents can be used in the treatment, but not every sarcoma responds to them equally. It is important to understand if testing of the tissue obtained during a routine biopsy or surgery may be useful in selecting appropriate treatments. In addition, additional testing of the tumor, including genetic testing, will help us to understand osteosarcoma better.",[72],"Osteosarcoma",[72],"2026-05-07",{"date":76,"type":77},"2026-05-11","ACTUAL",{"date":79,"type":77},"2024-02-12",{"date":81,"type":68},"2028-01-01",{"name":5,"class":6},1]