[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100608610":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":44,"centralContacts":49,"locations":59,"responsibleParty":73,"collaborators":43,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":79,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":43,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":98,"overallStatus":103,"whyStopped":43,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"Ataturk University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Bupivacaine Infiltration Group","ACTIVE_COMPARATOR","Patients will receive bupivacaine infiltration at the gallbladder bed and trocar sites following laparoscopic cholecystectomy. After removal of the gallbladder, 20 mL of 0.25% bupivacaine will be applied to the gallbladder bed using a sterile sponge for 10-15 minutes. At the end of surgery, a total of 20 mL 0.25% bupivacaine will be infiltrated at trocar insertion sites (8 mL umbilical port, 6 mL epigastric port, 3 mL each auxiliary port).",[13],"Drug: Bupivacaine Infiltration",{"label":15,"type":10,"description":16,"interventionNames":17},"Erector Spinae Plane Block Group","Patients will undergo bilateral erector spinae plane block under ultrasound guidance before induction of anesthesia. Under ultrasound guidance at the T7 transverse process level, a total of 40 mL of 0.25% bupivacaine will be injected bilaterally using an in-plane technique prior to induction of anesthesia.",[18],"Procedure: Erector Spinae Plane Block",{"label":20,"type":10,"description":21,"interventionNames":22},"Intrathecal Morphine Group","Patients will receive intrathecal morphine prior to induction of anesthesia. With the patient in a sitting position, a 27G spinal needle will be inserted at the L3-L4 interspace, and 200 mcg of morphine will be administered intrathecally before induction of anesthesia.",[23],"Drug: Intrathecal Morphine",[25,32,39],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","Bupivacaine Infiltration","After removal of the gallbladder, 40 mL of 0.25% bupivacaine will be applied to the gallbladder bed with a sterile sponge for 10-15 minutes. At the end of the surgery, 15 mL of 0.25% bupivacaine will be infiltrated into trocar insertion sites (5 mL umbilical port, 5 mL epigastric port, 5 mL each auxiliary port).",[9],[31],"Marcaine; Local Infiltration",{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":37},"PROCEDURE","Erector Spinae Plane Block","Before induction of anesthesia, a bilateral ultrasound-guided erector spinae plane block will be performed at the T7 transverse process level. A total of 40 mL of 0.25% bupivacaine will be injected (20 mL per side) using an in-plane technique under ultrasound guidance.",[15],[38],"ESP Block; Regional Anesthesia",{"type":26,"name":40,"description":41,"armGroupLabels":42,"otherNames":43},"Intrathecal Morphine","With the patient in the sitting position, a 27-gauge spinal needle will be inserted at the L3-L4 interspace. A dose of 100 mcg morphine will be administered intrathecally before induction of anesthesia.",[20],null,[45],{"name":46,"affiliation":47,"role":48},"Havva Yavuz Kayık, assistant doctor","Ataturk University Department of Anesthesiology and Reanimation","STUDY_DIRECTOR",[50,55],{"name":51,"role":52,"phone":53,"phoneExt":43,"email":54},"İrem Ateş, Doçent Doctor","CONTACT","+90 532 740 12 58","driremates@hotmail.com",{"name":56,"role":52,"phone":57,"phoneExt":43,"email":58},"Mehmet Akif Yılmaz, assistant doctor","+90 534 653 35 39","mehmetakifyilmaz025@gmail.com",[60],{"facility":5,"status":43,"city":61,"state":43,"zip":62,"country":63,"countryCode":43,"cosmosGeoPoint":64,"geoPoint":69,"contacts":70},"Erzurum","25000","Turkey (Türkiye)",{"type":65,"coordinates":66},"Point",[67,68],41.27694,39.90861,{"lat":68,"lon":67},[71],{"name":56,"role":52,"phone":72,"phoneExt":43,"email":58},"+90-534-653-35-39",{"type":74,"investigatorFullName":75,"investigatorTitle":76,"investigatorAffiliation":5,"oldNameTitle":43,"oldOrganization":43},"PRINCIPAL_INVESTIGATOR","irem ateş","Associate Professor as the Principal Investigator","100608610","analgesic-efficacy-of-bupivacaine-infiltration-erector-spinae-plane-block-and-intrathecal-morphine-in-laparoscopic-cholecystectomy-100608610",false,"NCT07203794","Analgesic Efficacy of Bupivacaine Infiltration, Erector Spinae Plane Block, and Intrathecal Morphine in Laparoscopic Cholecystectomy","A Prospective, Randomized Controlled Study Comparing the Analgesic Efficacy of Bupivacaine Infiltration of the Gallbladder Bed and Trocar Sites, Erector Spinae Plane Block, and Intrathecal Morphine in Patients Undergoing Laparoscopic Cholecystectomy","ITM-ESP-IPLA","Inclusion Criteria:\n\n* Adults aged 18-65 years\n* Scheduled for elective laparoscopic cholecystectomy\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Body mass index (BMI) \\> 35 kg\u002Fm²\n* History of coagulopathy or bleeding disorders\n* Known allergy or hypersensitivity to opioids or local anesthetics\n* Chronic pain or regular analgesic use\n* History of neurological or psychiatric disease\n* Pregnancy\n* Refusal to participate in the study","ALL","18 Years","65 Years",{"count":89,"type":90},132,"ESTIMATED","INTERVENTIONAL",[93],"NA","This study is designed to compare three different methods of pain control after laparoscopic gallbladder surgery (laparoscopic cholecystectomy). Although this surgery is minimally invasive, participants often experience different types of pain after the operation, such as pain at the incision site, pain inside the abdomen, and shoulder pain caused by the gas used during surgery.\n\nThe investigators will compare three commonly used pain relief techniques:\n\nLocal infiltration - injecting a numbing medicine (bupivacaine) into the gallbladder bed and at the sites where the surgical instruments are placed.\n\nErector spinae plane (ESP) block - an ultrasound-guided nerve block performed in the back to reduce both abdominal and incisional pain.\n\nIntrathecal morphine - a very small dose of morphine given into the spinal fluid before surgery to provide long-lasting pain relief.\n\nThe goal is to determine which method provides the best pain control, reduces the need for opioid medications, and improves recovery after surgery.",[96,97],"Postoperative Pain Management","Cholecystectomy, Laparoscopic",[99,100,27,34,40,101,102],"Laparoscopic Cholecystectomy","Postoperative Pain","Analgesia","Opioid Consumption","NOT_YET_RECRUITING","2025-11-20",{"date":106,"type":107},"2025-11-25","ACTUAL",{"date":109,"type":90},"2025-12-01",{"date":111,"type":90},"2026-04-02",{"name":5,"class":6},1]