[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100518050":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":22,"centralContacts":27,"locations":36,"responsibleParty":52,"collaborators":10,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":56,"sex":62,"minAge":10,"maxAge":10,"enrollmentInfo":63,"targetDuration":10,"studyType":66,"phases":10,"briefSummary":67,"conditions":68,"keywords":10,"overallStatus":39,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"University Medical Center Groningen","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"EBV-patients",null,"Patients who are scheduled for a bronchoscopic lung volume reduction treatment using endobronchial valves.",[13],"Diagnostic Test: 31P-Magnetic Resonance Spectroscopy (31P-MRS)",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DIAGNOSTIC_TEST","31P-Magnetic Resonance Spectroscopy (31P-MRS)","31P-Magnetic Resonance Spectroscopy will be performed during exercise testing.",[9],[21],"Muscle biopsy",[23],{"name":24,"affiliation":25,"role":26},"Dirk-Jan Slebos, MD PhD","UMC Groningen","PRINCIPAL_INVESTIGATOR",[28,33],{"name":29,"role":30,"phone":31,"phoneExt":10,"email":32},"Else ter Haar, MD","CONTACT","+31503619194","e.a.m.d.ter.haar@umcg.nl",{"name":34,"role":30,"phone":31,"phoneExt":10,"email":35},"Jorine Hartman, PhD","j.hartman@umcg.nl",[37],{"facility":38,"status":39,"city":40,"state":10,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Univeristy Medical Center Groningen","RECRUITING","Groningen","Netherlands","NL",{"type":44,"coordinates":45},"Point",[46,47],6.56667,53.21917,{"lat":47,"lon":46},[50,51],{"name":29,"role":30,"phone":10,"phoneExt":10,"email":10},{"name":34,"role":30,"phone":10,"phoneExt":10,"email":10},{"type":53,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100518050","analysing-peripheral-skeletal-muscle-function-before-and-after-endobronchial-valve-treatment-100518050",false,"NCT06025500","Analysing Peripheral Skeletal Muscle Function Before and After Endobronchial Valve Treatment","Analysing cEllular Bioenergetics aNd Structural aDaptations in the qUadriceps Muscle befoRe and After endobroNChial Valve treatmEnt","ENDURANCE","Inclusion Criteria:\n\n* Patient is scheduled for a bronchoscopic lung volume treatment using one-way endobronchial valves;\n* Patient read, understood and signed the Informed Consent Form.\n\nExclusion Criteria:\n\n* Inability to perform a cycle ergometry test;\n* Contraindications for undergoing a magnetic resonance imaging scan (e.g. claustrophobia, implanted cardiac devices);\n* Body length \\>190cm;\n* Any anticoagulant therapy;\n* COPD exacerbation 4 weeks prior to testing.","ALL",{"count":64,"type":65},15,"ESTIMATED","OBSERVATIONAL","Rationale: Chronic obstructive pulmonary disease (COPD) is characterised by a high prevalence of peripheral muscle dysfunction, which can have significant clinical consequences, including decreased exercise capacity, reduced quality of life, and even a higher mortality rate. Reduction of lung hyperinflation using bronchoscopic lung volume reduction treatment with one-way endobronchial valves (EBV) is a minimally invasive intervention which improves exercise capacity and physical activity in patients with severe emphysema. This positive effect is also related to weight gain and alterations in body composition. The physiologic and structural adaptations of skeletal muscle function after EBV treatment has never been investigated before.\n\nObjective: To investigate the physiological and structural adaptations of peripheral muscle function at a cellular level in response to EBV treatment.\n\nStudy design: A single center, prospective clinical trial with a single-arm pretest-posttest design. Patients with severe emphysema who will receive a bronchoscopic lung volume reduction treatment are asked to undergo additional in-magnet exercise testing and muscle biopsies before and after placement of EBVs.\n\nStudy population: Patients with severe emphysema who are scheduled to undergo EBV treatment.\n\nMain study parameters\u002Fendpoints: The difference in quadriceps phosphocreatine concentration (PCr), quadriceps inorganic phosphorus concentration (Pi), and quadriceps pH at rest, during progressive exercise, and recovery rate will be measured by 31P-MRS to assess the physiological effect of EBV treatment on skeletal muscle function and its bioenergetics. Furthermore, we will perform a detailed histological and biochemical analysis of muscle fiber type composition, mitochondrial density, master regulators of muscle oxidative programming, and mitochondrial respiration before and after EBV treatment.",[69],"Emphysema","2026-04-24",{"date":72,"type":73},"2026-04-29","ACTUAL",{"date":75,"type":73},"2024-10-01",{"date":77,"type":65},"2026-12-01",{"name":5,"class":6},1]