[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626411":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":16,"centralContacts":20,"locations":30,"responsibleParty":48,"collaborators":51,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":7,"enrollmentInfo":64,"targetDuration":7,"studyType":67,"phases":7,"briefSummary":68,"conditions":69,"keywords":74,"overallStatus":33,"whyStopped":7,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"McGill University Health Centre\u002FResearch Institute of the McGill University Health Centre","OTHER",null,[9,13],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"DIAGNOSTIC_TEST","Venous blood sampling","-Venous blood samples (1-2 mL) will be collected into EDTA and serum-separator vacutainer tubes. Samples will be processed within one hour by centrifugation (1,500g, 10 min, 4°C), and plasma\u002Fserum aliquots will be stored at -80°C",{"type":10,"name":14,"description":15,"armGroupLabels":7,"otherNames":7},"Dried blood spot sampling","-DBS samples will be collected via finger prick (using a lancet) onto certified filter paper (Dried Blood Spot Sample Collection Kit with Lancets, Salimetrics, LLC; State College, PA, USA). Two blood spots (\\~20 µL each) will be dried at room temperature for at least two hours, then stored in a sealed bag at -20°C with desiccant. Validated guidelines for the collection, storage and preparation of DBS samples will be followed to ensure proper quality control.",[17],{"name":18,"affiliation":5,"role":19},"Emily G. McDonald, MD MSc","PRINCIPAL_INVESTIGATOR",[21,27],{"name":22,"role":23,"phone":24,"phoneExt":25,"email":26},"Kristen Moran, BSc.","CONTACT","514-934-1934","x23730","cpau.med@mcgill.ca",{"name":28,"role":23,"phone":24,"phoneExt":29,"email":26},"Evelyn Laferrière, BSc.","23730",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Research Institute of the McGill University Health Centre","RECRUITING","Montreal","Quebec","H4A 0B1","Canada","CA",{"type":40,"coordinates":41},"Point",[42,43],-73.58781,45.50884,{"lat":43,"lon":42},[46,47],{"name":22,"role":23,"phone":24,"phoneExt":29,"email":26},{"name":18,"role":19,"phone":7,"phoneExt":7,"email":7},{"type":19,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Emily McDonald","MD MSc",[52],{"name":53,"class":54},"Sensifai Health","UNKNOWN","100626411","analysis-of-inflammatory-biomarker-changes-in-dry-blood-spot-versus-venous-blood-samples-100626411",false,"NCT07435285","Analysis of Inflammatory Biomarker Changes in Dry Blood Spot Versus Venous Blood Samples","DBS-VB","Inclusion Criteria:\n\n* Men or women aged ≥18 years, who are planning to receive a seasonal vaccine OR have a scheduled acute stressor\\*.\n\nExclusion Criteria:\n\n* Any infectious symptoms (fever, cough, rhinorrhea, sore throat, diarrhea, loss of smell or taste) within the previous 7 days\n* Any self-reported active\u002Frecent use of cocaine, injection drugs, or amphetamines\n* Acute worsening of a known chronic health condition within the previous 30 days (e.g., of IBD, COPD, asthma, rheumatologic disease)\n* Known severe allergy or intolerance to the planned vaccine\n* Contraindication to the vaccine received, if applicable\n\n  \\*List of possible scheduled acute stressors include:\n* Hard exercise (incl. 10km run or longer, high-intensity interval training, or comparable endurance activity)\n* Social event with moderate alcohol consumption\n* Planned change in medication dose and\u002For frequency of use\n* Onset of menstruation (day 1)\n* Other pre-planned stressors expected to elicit an inflammatory response","ALL","18 Years",{"count":65,"type":66},50,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to see whether dried blood spot (DBS) samples can measure inflammatory biomarkers as accurately as venous blood samples.\n\nInvestigators will be measuring inflammatory biomarkers changes obtained in DBS compared with paired venous blood samples following a controlled physiological stressor (i.e. after a vaccine or other planned event that can cause a temporary rise in inflammation).\n\nThese findings will help understand whether DBS can be a reliable alternative to traditional blood draws in future research and healthcare.",[70,71,72,73],"Inflammation","Inflammation Biomarkers","Blood Sampling","Dried Blood Spot",[75,76,77,78,79,80],"inflammation","blood sampling","biomarkers","inflammatory biomarkers","dried blood spot","paired sampling","2026-03-23",{"date":83,"type":84},"2026-03-27","ACTUAL",{"date":86,"type":84},"2026-01-15",{"date":88,"type":66},"2026-12",{"name":5,"class":6},1]