[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100614127":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":21,"responsibleParty":40,"collaborators":10,"id":42,"slug":43,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":10,"eligibilityCriteria":47,"healthyVolunteers":44,"sex":48,"minAge":49,"maxAge":10,"enrollmentInfo":50,"targetDuration":10,"studyType":53,"phases":10,"briefSummary":54,"conditions":55,"keywords":10,"overallStatus":23,"whyStopped":10,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":68},{"fullName":5,"class":6},"Qilu Hospital of Shandong University","OTHER",[8,11,13],{"label":9,"type":10,"description":10,"interventionNames":10},"Chronic hepatitis B",null,{"label":12,"type":10,"description":10,"interventionNames":10},"Hepatitis B-related liver cirrhosis",{"label":14,"type":10,"description":10,"interventionNames":10},"Hepatitis B-related acute-on-chronic liver failure",[16],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"Yu-Chen Fan","CONTACT","0086+053182169593","fanyuchen@sdu.edu.cn",[22],{"facility":5,"status":23,"city":24,"state":25,"zip":26,"country":27,"countryCode":28,"cosmosGeoPoint":29,"geoPoint":34,"contacts":35},"RECRUITING","Jinan","Shandong","250012","China","CN",{"type":30,"coordinates":31},"Point",[32,33],116.99722,36.66833,{"lat":33,"lon":32},[36,38],{"name":17,"role":18,"phone":37,"phoneExt":10,"email":20},"0086+053182169596",{"name":17,"role":39,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"type":41,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100614127","analysis-of-methylomic-features-and-prognostic-risk-prediction-in-patients-with-hepatitis-b-related-acute-on-chronic-liver-failure-100614127",false,"NCT07275554","Analysis of Methylomic Features and Prognostic Risk Prediction in Patients With Hepatitis B-related Acute-on-chronic Liver Failure","Inclusion Criteria:\n\n* Chronic hepatitis B was persistent hepatitis B surface antigen (HBsAg) seropositivity for more than six months.\n\nHepatitis B-related liver cirrhosis was diagnosed based on histological examination, typical features on ultrasound or radiological imaging, endoscopic findings of portal hypertension, and clinical history.\n\nHepatitis B-related acute-on-chronic liver failure meets the diagnostic criteria of the 2018 Asia-Pacific guidelines for the diagnosis and treatment of liver failure.Laboratory tests:Jaundice: Serum total bilirubin ≥ 85 µmol\u002FL and coagulopathy \\[International Normalized Ratio (INR) ≥ 1.5 or Prothrombin Activity (PTA) \\\u003C 40%\\].\n\nExclusion Criteria:\n\n* co-infection with other hepatitis viruses; history of hepatocellular carcinoma or other malignancies; concomitant autoimmune liver disease; or insufficient clinical data.","ALL","18 Years",{"count":51,"type":52},100,"ESTIMATED","OBSERVATIONAL","This study aims to investigate the methylomic features of patients with hepatitis B-related acute-on-chronic liver failure and establish and validate a prognostic risk prediction classification model. The findings are of significant importance for guiding clinical practice and improving patient prognosis. Additionally, a methylomics-based classifier model for liver failure will be developed for disease prognosis analysis and clinical assessment, with the potential to enhance the diagnostic efficiency of liver failure.",[56,57,58],"HBV Related Acute-on-chronic Liver Failure","HBV-related Liver Cirrhosis","HBV (Hepatitis B Virus)","2025-11-27",{"date":61,"type":62},"2025-12-10","ACTUAL",{"date":64,"type":62},"2024-12-31",{"date":66,"type":52},"2026-12-31",{"name":5,"class":6},1]