[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100615973":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":11,"locations":21,"responsibleParty":39,"collaborators":10,"id":42,"slug":43,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":44,"sex":50,"minAge":51,"maxAge":10,"enrollmentInfo":52,"targetDuration":10,"studyType":55,"phases":10,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":24,"whyStopped":10,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"University Hospital, Bonn","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":10},"Patients presenting with an infected knee prosthesis",null,[12,17],{"name":13,"role":14,"phone":15,"phoneExt":10,"email":16},"Alexander Franz, Dr. med., B. Sc.","CONTACT","+491703750718","alexander.franz@ukbonn.de",{"name":18,"role":14,"phone":19,"phoneExt":10,"email":20},"Julika Behrens","+4915752849422","julika.behrens@ukbonn.de",[22],{"facility":23,"status":24,"city":25,"state":26,"zip":27,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":36},"University Hospital Bonn","RECRUITING","Bonn","North Rhine-Westphalia","53127","Germany","DE",{"type":31,"coordinates":32},"Point",[33,34],7.09549,50.73438,{"lat":34,"lon":33},[37],{"name":38,"role":14,"phone":15,"phoneExt":10,"email":16},"Alexander Franz",{"type":40,"investigatorFullName":38,"investigatorTitle":41,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Dr. med., B. Sc.","100615973","analysis-of-pharmacological-aspects-regarding-infection-free-survival-after-surgical-treatment-of-a-periprosthetic-knee-infection-a-microdialysis-study-100615973",false,"NCT07299565","Analysis of Pharmacological Aspects Regarding Infection Free Survival After Surgical Treatment of a Periprosthetic Knee Infection: a Microdialysis Study","Analysis of Immunological and Pharmacological Aspects Regarding Infection Free Survival After Surgical Treatment of a Periprosthetic Knee Infection During Hospitalization: a Microdialysis Study","PJI_K_MD","Inclusion Criteria:\n\n* clinical indication for two-stage revision of knee PJI\n* approval for surgery by the orthopedic and anesthesiologic department\n* being over 18 years of age\n* written, informed consent after detailed patient information about the study protocol and possible study dependent risks\n\nExclusion Criteria:\n\n* known allergies to antibiotics gentamicin and vancomycin used within the spacer","ALL","18 Years",{"count":53,"type":54},30,"ESTIMATED","OBSERVATIONAL","This study aims to use the technique of microdialysis to analyse the intraarticular space of the knee joint after removal of a periprosthetic joint infection affected endoprosthesis and implantation of an antibiotic-containing cement spacer over the entire period of the first hospitalization (usually 14 days) to closely monitor pharmacological and immunological aspects. In detail, antibiotic concentrations in the joint cavity and systemic circulation will be assessed according to reinfection rates, infection-free survival and fucntional outcome over a 12-month folluw-up period.",[58],"Periprosthetic Knee Infection",[60,61,62,63,64,65,66,67,68],"two-stage exchange","infection","PJI","microdialysis","infection free survival","treatment monitoring","muscle mass","patient reported outcom measures","bone cement","2025-12-09",{"date":71,"type":72},"2025-12-23","ACTUAL",{"date":74,"type":72},"2025-11-15",{"date":76,"type":54},"2027-11-01",{"name":5,"class":6},1]