[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100589676":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":21,"locations":31,"responsibleParty":47,"collaborators":51,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":64,"enrollmentInfo":65,"targetDuration":10,"studyType":68,"phases":10,"briefSummary":69,"conditions":70,"keywords":72,"overallStatus":34,"whyStopped":10,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Karolinska Institutet","OTHER",[8,12,15,18],{"label":9,"type":10,"description":11,"interventionNames":10},"NC",null,"caries-free children",{"label":13,"type":10,"description":14,"interventionNames":10},"C","children with clinically detectable caries (initial or manifest)",{"label":16,"type":10,"description":17,"interventionNames":10},"proteom Järva","proteome of 3-year-old children examined in Folktandvården Järva",{"label":19,"type":10,"description":20,"interventionNames":10},"proteom Danderyd","proteome of 3-year-old children examined in Folktandvården Danderyd",[22,27],{"name":23,"role":24,"phone":25,"phoneExt":10,"email":26},"Franziska Anna Hetrodt, Dr. med. dent.","CONTACT","+46852488273","franziska.hetrodt@ki.se",{"name":28,"role":24,"phone":29,"phoneExt":10,"email":30},"Maria Anderson, PhD","+468-123 152 03","maria.anderson@regionstockholm.se",[32],{"facility":33,"status":34,"city":35,"state":10,"zip":10,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Folktandvården Stockholms län AB","RECRUITING","Stockholm","Sweden","SE",{"type":39,"coordinates":40},"Point",[41,42],18.06871,59.32938,{"lat":42,"lon":41},[45],{"name":28,"role":24,"phone":46,"phoneExt":10,"email":30},"+46 8-123 165 38",{"type":48,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Franziska Hetrodt","Lecturer",[52],{"name":33,"class":53},"OTHER_GOV","100589676","analysis-of-salivary-proteins-in-young-children-as-an-device-to-improve-caries-risk-assessment-100589676",false,"NCT06957509","Analysis of Salivary Proteins in Young Children as an Device to Improve Caries Risk Assessment","Salivary Metaproteome as a Prediction Tool in Early Childhood Caries","DecodECC","Inclusion Criteria:\n\n* 3-year-old children residing in the areas served by Folktandvården Danderyd and Järva, respectively\n* Written consent, signed by both parents (guardians)\n\nExclusion Criteria:\n\n* children older than three years\n* medication intake, and antibiotic use at the time of examination\n* children who have consumed food, drink, or used oral hygiene products within 2 hours before the dental visit\n* children who appear uncooperative during saliva sampling",true,"ALL","3 Years",{"count":66,"type":67},100,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn if the composition of salivary proteins in 3-year-old children, from communities with documented varying caries risks, can be used to identify future diagnostic predictors for caries risk.\n\nThe main question to answer is:\n\n• Can the host´s salivary protein profile (expression and abundance) show a correlation with the caries prevalence between the individuals in the different study cohorts?\n\nTwo cohorts of children with different documented demographic characteristics in the region of Stockholm (Sweden) will be examined.\n\nParticipants will be asked to provide saliva samples and undergo clinical oral examinations conducted by trained dental practitioners.",[71],"Early Childhood Caries (ECC)",[73,74,75,76],"early childhood caries","saliva","metaproteins","caries risk assessment","2025-05-02",{"date":79,"type":80},"2025-05-04","ACTUAL",{"date":82,"type":80},"2025-04-04",{"date":84,"type":67},"2027-12",{"name":5,"class":6},1]