[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100563088":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":41,"centralContacts":46,"locations":55,"responsibleParty":68,"collaborators":23,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":72,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":23,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":57,"whyStopped":23,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Istituto Ortopedico Rizzoli","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Knee Osteoarthritis","EXPERIMENTAL","Elderly patients with knee osteoarthritis, without a history of falls (in the 12 months prior to enrollment).\n\nAll subjects will be followed up for 24 months, every 6 months. Muscle force and power assessments, plus a home-based mobility monitoring, will be performed at all visits. Full lower limb MRI and a gait assessment will be performed at first and last visit.",[13,14,15,16,17],"Other: Muscle power assessment","Other: Muscle force assessment","Other: Home-based mobility monitoring","Diagnostic Test: Magnetic Resonance Imaging","Other: Gait assessment",[19,24,28,32,37],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"Muscle power assessment","Isokinetic dynamometry test Stair ascent\u002Fdescent on instrumented stairs",[9],null,{"type":6,"name":25,"description":26,"armGroupLabels":27,"otherNames":23},"Muscle force assessment","Isometric dynamometry (Maximal Voluntary Isometric Contraction)",[9],{"type":6,"name":29,"description":30,"armGroupLabels":31,"otherNames":23},"Home-based mobility monitoring","Mobility monitoring with wearable sensors",[9],{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":23},"DIAGNOSTIC_TEST","Magnetic Resonance Imaging","Full lower limb MRI",[9],{"type":6,"name":38,"description":39,"armGroupLabels":40,"otherNames":23},"Gait assessment","Motion capture, surface EMG and gorund reaction force data",[9],[42],{"name":43,"affiliation":44,"role":45},"Lisa Berti, Professor","IRCCS Istituto Ortopedico Rizzoli","PRINCIPAL_INVESTIGATOR",[47,51],{"name":43,"role":48,"phone":49,"phoneExt":23,"email":50},"CONTACT","+390516366529","lisa.berti@ior.it",{"name":52,"role":48,"phone":53,"phoneExt":23,"email":54},"Massimiliano Baleani, Engineer","+390516366865","massimiliano.baleani@ior.it",[56],{"facility":44,"status":57,"city":58,"state":23,"zip":59,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":23},"RECRUITING","Bologna","40136","Italy","IT",{"type":63,"coordinates":64},"Point",[65,66],11.33875,44.49381,{"lat":66,"lon":65},{"type":69,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR","100563088","analysis-of-the-loss-of-muscle-force-power-and-motor-control-to-predict-the-risk-of-falls-in-patients-with-knee-oa-100563088",false,"NCT06611618","Analysis of the Loss of Muscle Force, Power and Motor Control to Predict the Risk of Falls in Patients With Knee OA","Analisi Della Perdita di Forza e Potenza Muscolare e Del Degrado Del Controllo Motorio Per la Predizione Delle Cadute in Una Popolazione Affetta da Artrosi di Ginocchio","PowerAGING","Inclusion Criteria:\n\n* Age between 65 and 80 years\n* Kellgren score II e III\n* No history of falls in the last 12 months\n\nExclusion Criteria:\n\n* Any musculoskeletal, neurological, rheumatic or tumoral diseases\n* Dementia\n* Diabetes\n* Inguinal or abdominal hernia\n* Severe Hypertension (Level 3)\n* Severe Cardio-pulmonary insufficiency\n* Diagnosis of Osteonecrosis in the lower limb joints\n* Pathologies or physical conditions incompatible with the use of magnetic resonance imaging and electrostimulation (i.e., active and passive implanted biomedical devices, epilepsy, severe venous insufficiency in the lower limbs)\n* Previous interventions or traumas to the joints of the lower limb","ALL","65 Years","80 Years",{"count":82,"type":83},50,"ESTIMATED","INTERVENTIONAL",[86],"NA","The twofold goal of this study is to understand the link between muscle power, muscle strength, and muscle control degradation with the risk of falling, and to develop a framework for the comprehensive and quantitative assessment of muscle power (and strength) in an elderly population of patients with knee osteoarthritis, who are at higher risk of falling. The main question it aims to answer is:\n\n● Are muscle power and motor control degradation better predictors of falls than muscle strength in the aging population?\n\nParticipants will undergo:\n\n* Muscle force assessment on a dynamometer\n* Muscle power assessment on a dynamometer and on isntrumented stairs\n* Home-based mobility monitoring\n* Full lower limb MRI acquisition\n* Gait assessment",[89,90],"Knee Osteoarthritis (Knee OA)","Falls Prevention",[92,93,94,95,96,97,98,99,100],"Falls prevention","Knee osteoarthritis","Muscle power","Muscle force","Motor control degradation","digital twins","IMU","mobility monitoring","MRI","2026-02-24",{"date":103,"type":104},"2026-02-27","ACTUAL",{"date":106,"type":104},"2025-01-30",{"date":108,"type":83},"2026-12-12",{"name":5,"class":6},1]