[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644491":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":20,"locations":19,"responsibleParty":26,"collaborators":19,"id":28,"slug":29,"hasResults":30,"nctId":31,"briefTitle":32,"officialTitle":33,"acronym":19,"eligibilityCriteria":34,"healthyVolunteers":30,"sex":35,"minAge":36,"maxAge":19,"enrollmentInfo":37,"targetDuration":19,"studyType":40,"phases":41,"briefSummary":43,"conditions":44,"keywords":19,"overallStatus":46,"whyStopped":19,"lastUpdateSubmitDate":47,"lastUpdatePostDateStruct":48,"startDateStruct":51,"completionDateStruct":53,"leadSponsor":55,"locationsCount":19},{"fullName":5,"class":6},"Lifecord Otd","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Anchord Device","EXPERIMENTAL","Anchord device implantation",[13],"Device: Anchord device implantation",[15],{"type":16,"name":11,"description":17,"armGroupLabels":18,"otherNames":19},"DEVICE","Anchord Mitral Chordal Repair device implantation",[9],null,[21],{"name":22,"role":23,"phone":24,"phoneExt":19,"email":25},"Shaily Shohat","CONTACT","+972549546605","shaily.s@life-cord.com",{"type":27,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100644491","anchord-mitral-chordal-repair-system---fih-100644491",false,"NCT07671820","Anchord Mitral Chordal Repair System - FIH","Anchord Mitral Chordal Repair System for Patients With Degenerative Mitral Regurgitation","Inclusion Criteria:\n\n* Severe symptomatic degenerative mitral regurgitation (grade 3+)\n* High surgical risk for open-heart mitral valve repair or replacement\n* Suitable anatomy for transcatheter chordal repair as determined by the treating physician\n* Ability to undergo required echocardiographic and fluoroscopic imaging\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Active endocarditis or systemic infection\n* Severe left ventricular dysfunction (LVEF \\\u003C30%)\n* Significant non-mitral valvular disease requiring intervention\n* Severe mitral annular calcification (MAC)\n* Presence of intracardiac or femoral venous thrombus or thrombus in the inferior vena cava\n* Cerebrovascular events (TIA, CVA) or thromboembolic events within the previous 6 months.\n* Renal insufficiency\n* Inability to undergo required imaging or access\n* Inability to tolerate standard anticoagulation or antithrombotic regimen\n* Rheumatic mitral valve disease\n* Co-morbid condition limiting life expectancy or study completion\n* Pregnancy\n* Participation in another clinical trial\n* Previous device treatment for MR.","ALL","18 Years",{"count":38,"type":39},5,"ESTIMATED","INTERVENTIONAL",[42],"NA","The goal of this clinical trial is to generate initial human clinical experience and evaluate procedural feasibility, device deployment, and early safety under controlled First-In-Human conditions for the Anchord Mitral Chordal Repair System in patients with degenerative mitral regurgitation. The main question\\[s\\] it aims to answer are to assess the safety of procedure, the reduction in mitral regurgitation severity and changes in hemodynamic and symptomatic status.\n\nParticipants will be implanted with the Anchord device.",[45],"Mitral Regurgitation","NOT_YET_RECRUITING","2026-06-23",{"date":49,"type":50},"2026-06-26","ACTUAL",{"date":52,"type":39},"2026-07",{"date":54,"type":39},"2028-12",{"name":5,"class":6}]