[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100606900":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":33,"centralContacts":41,"locations":47,"responsibleParty":63,"collaborators":33,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":33,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":33,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":94,"overallStatus":49,"whyStopped":33,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"University General Hospital of Patras","OTHER",[8,14,19,24],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm 1: Propofol-Remifentanil (TIVA)","ACTIVE_COMPARATOR","Maintenance of general anesthesia with propofol and remifentanil; no ketamine or magnesium administered.",[13],"Drug: Propofol \u002F Remifentanil",{"label":15,"type":10,"description":16,"interventionNames":17},"Arm 2: Propofol-Remifentanil + Ketamine + Magnesium (TIVA+)","Maintenance with propofol and remifentanil plus adjunct continuous infusions of ketamine and magnesium.",[13,18],"Drug: Ketamine + Magnesium sulfate (drug combination)",{"label":20,"type":10,"description":21,"interventionNames":22},"Arm 3: Sevoflurane-Remifentanil (Inhalational)","Maintenance of general anesthesia with sevoflurane and remifentanil; no ketamine or magnesium administered.",[23],"Drug: Sevoflurane and Remifentanil",{"label":25,"type":10,"description":26,"interventionNames":27},"Arm 4: Sevoflurane-Remifentanil + Ketamine + Magnesium (Inhalational+)","Maintenance with sevoflurane and remifentanil plus adjunct continuous infusions of ketamine and magnesium.",[18,23],[29,34,38],{"type":30,"name":31,"description":11,"armGroupLabels":32,"otherNames":33},"DRUG","Propofol \u002F Remifentanil",[9,15],null,{"type":30,"name":35,"description":36,"armGroupLabels":37,"otherNames":33},"Ketamine + Magnesium sulfate (drug combination)","Continuous intraoperative infusion per protocol.",[15,25],{"type":30,"name":39,"description":36,"armGroupLabels":40,"otherNames":33},"Sevoflurane and Remifentanil",[20,25],[42],{"name":43,"role":44,"phone":45,"phoneExt":33,"email":46},"Sotiria Rizopoulou, M.D.,M.Sc.","CONTACT","+306949454352","rizsotiria@gmail.com",[48],{"facility":5,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"RECRUITING","Pátrai","Achaia","26504","Greece","GR",{"type":56,"coordinates":57},"Point",[58,59],21.73508,38.2462,{"lat":59,"lon":58},[62],{"name":43,"role":44,"phone":45,"phoneExt":33,"email":46},{"type":64,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":33,"oldOrganization":33},"PRINCIPAL_INVESTIGATOR","Sotiria Rizopoulou","Chief Resident Anesthesioogy","100606900","anesthesia-techniques-neuroprotection-and-surgical-field-in-fess-under-controlled-hypotension-100606900",false,"NCT07181564","Anesthesia Techniques, Neuroprotection and Surgical Field in FESS Under Controlled Hypotension","FUNCTIONAL ENDOSCOPIC NASAL AND SINUS SURGERY AND ANESTHESIA: Study of Hemodynamic Parameters During General Anesthesia Compared to the Surgical Field, as Well as Assessment of Cerebral Ischemia Intraoperatively by Measurement of S100B Protein and Specific Neuronal Enolase (NSE).","Inclusion Criteria :\n\nAdult patients (≥18 years old). Scheduled for F.E.S.S (Functional endoscopic sinus surgery ) under general anesthesia.\n\nAble to provide informed consent\n\nExclusion Criteria:\n\nEmergency surgery. ASA physical status IV-V. Severe hepatic or renal dysfunction. Known allergy or contraindication to study drugs. Pregnant or lactating women. unable to provide informed consent\n\nPatients unwilling or unable to provide consent.","ALL","18 Years","90 Years",{"count":78,"type":79},150,"ESTIMATED","INTERVENTIONAL",[82],"NA","This prospective, randomized controlled trial investigates the effect of four different anesthetic maintenance techniques on surgical field conditions, hemodynamic stability, and neuroprotection during functional endoscopic sinus surgery (FESS) performed under controlled hypotension. Patients are randomly assigned to receive either total intravenous anesthesia with propofol-remifentanil, propofol-remifentanil with adjunct ketamine and magnesium, sevoflurane-remifentanil, or sevoflurane-remifentanil with adjunct ketamine and magnesium. Primary outcomes include serum biomarkers of neuronal injury (S100B and neuron-specific enolase, NSE) measured perioperatively, as well as surgical field visibility and intraoperative bleeding scores. Secondary outcomes include recovery profile and postoperative pain.",[85,86,87,88,89,90,91,92,93],"Magnesium Sulfate","Remifentanil","S 100beta","S100 Beta Protein, Human","Neuron-Specific Enolase","Brain Ischemia","Sevoflurane Anaesthesia","Propofol\u002FRemifentanil","Ketamine",[95],"\"Anesthesia\", \"Controlled Hypotension\", \"FESS\", \"S100B\", \"Neuron-Specific Enolase\"","2025-09-11",{"date":98,"type":99},"2025-09-18","ACTUAL",{"date":96,"type":99},{"date":102,"type":79},"2026-03-20",{"name":5,"class":6},1]