[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100459261":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":29,"responsibleParty":46,"collaborators":19,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":19,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":55,"minAge":56,"maxAge":19,"enrollmentInfo":57,"targetDuration":19,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":19,"overallStatus":32,"whyStopped":19,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"Johns Hopkins University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Standardized Protocol","EXPERIMENTAL","Preop considerations\n\n1\\. Ensure CBC, PT, PTT, type and cross are available, if not obtain with preop IV access\n\nPremed\n\n1. Acetaminophen PO 15mg\u002Fkg\n2. Scopolamine patch as indicated\n3. Midazolam as indicated PO or IV\n\nInduction\n\n1. Standard induction with lidocaine (1.5 mg\u002Fkg), propofol (1-3 mg\u002Fkg), and rocuronium (0.6mg\u002Fkg)\n2. Fentanyl 100 mcg bolus\n3. Dexmedetomidine 0.3 mcg\u002Fkg bolus\n4. Nasotracheal intubation (NTI) - surgical team will suture to nasal septum\n5. Place an additional PIV, ideally large gauge for volume resuscitation (18g or 16g)\n6. Dexamethasone 4-8mg q4-6 hours per surgical request\n7. Tranexamic acid 30mg\u002Fkg bolus (over 15 minutes)\n8. Ancef 30 mg\u002Fkg bolus\n\nMonitors \u002FAccess\n\n1. Standard ASA monitors\n2. Avoid placing nasal or oral temperature probe as this interferes with surgical exposure\n3. PIV x 2 is sufficient, have at least one large gauge PIV for volume resuscitation\n4. Arterial catheter not necessary but place as needed, especially if patient is medically compl",[13],"Other: Standardized Anesthetic Course from Premedication to Induction",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Standardized Anesthetic Course from Premedication to Induction","See information in intervention group description",[9],null,[21],{"name":22,"affiliation":5,"role":23},"Robin Yang, MD, DDS","PRINCIPAL_INVESTIGATOR",[25],{"name":22,"role":26,"phone":27,"phoneExt":19,"email":28},"CONTACT","443-997-9466","ryang14@jhmi.edu",[30],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Johns Hopkins Hospital","RECRUITING","Baltimore","Maryland","21287","United States","US",{"type":39,"coordinates":40},"Point",[41,42],-76.61219,39.29038,{"lat":42,"lon":41},[45],{"name":22,"role":26,"phone":27,"phoneExt":19,"email":28},{"type":47,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100459261","anesthetic-optimization-in-pediatric-lefort-surgeries-100459261",false,"NCT05260320","Anesthetic Optimization in Pediatric LeFort Surgeries","Inclusion Criteria:\n\n* Undergoing Le Fort osteotomy at Johns Hopkins Hospital\n* Age \\>= 14 years\n\nExclusion Criteria:\n\n* Contraindications to standardized anesthetic protocol (intervention arm)",true,"ALL","14 Years",{"count":58,"type":59},50,"ESTIMATED","INTERVENTIONAL",[62],"NA","This study will propose and evaluate a standardized LeFort osteotomy anesthetic protocol for pediatric patients at Johns Hopkins Hospital. There are two cohorts to this study: a prospective cohort who will receive the study anesthesia protocol and a historical cohort that received standard of care. The investigators hope this will help to minimize unnecessary postoperative pain management, inpatient stay, and long-term morbidity and mortality in these patients.",[65,66],"Le Fort","Pain, Postoperative","2026-05-18",{"date":69,"type":70},"2026-05-20","ACTUAL",{"date":72,"type":70},"2025-05-02",{"date":74,"type":59},"2027-07",{"name":5,"class":6},1]