[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632249":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":28,"locations":34,"responsibleParty":49,"collaborators":10,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":53,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":10,"studyType":65,"phases":10,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":75,"whyStopped":10,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Beijing Anzhen Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Retrospective cohort",null,"Patients who underwent successful OCT-guided PCI with stent implantation during the retrospective study period (January 2020 to March 2026) at participating centers in China where eligible archived angiographic, OCT, and follow-up data are available for analysis.",[13],"Procedure: OCT-guided PCI",{"label":15,"type":10,"description":16,"interventionNames":17},"Prospective cohort","Patients newly enrolled during the prospective study period (March 2026 to March 2027) at participating centers in China who undergo successful OCT-guided PCI with stent implantation and have post-procedural angiographic images suitable for Angio-FFR and Angio-IMR analysis.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"PROCEDURE","OCT-guided PCI","Not applicable as assigned study interventions. This is an observational study. OCT-guided PCI will be performed according to routine clinical practice at each participating center. Coronary angiographic images obtained before and after PCI will be used to derive angiography-based physiologic indices, including pre-PCI pullback pressure gradient (PPG) and post-PCI Angio-FFR and Angio-IMR, for physiologic characterization and outcome analysis.",[15,9],[25],{"name":26,"affiliation":5,"role":27},"min zhang","PRINCIPAL_INVESTIGATOR",[29],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},"Chenchen Tu, Doctor","CONTACT","+8615201648899","tcc2033@mail.ccmu.edu.cn",[35],{"facility":36,"status":10,"city":37,"state":10,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Beijing Anzhen Hospital, Capital Medical University","Beijing","China","CN",{"type":41,"coordinates":42},"Point",[43,44],116.39723,39.9075,{"lat":44,"lon":43},[47],{"name":48,"role":31,"phone":32,"phoneExt":10,"email":33},"Chenchen Tu",{"type":50,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100632249","angiography-derived-physiological-indices-for-outcome-prediction-in-patients-undergoing-oct-guided-pci-100632249",false,"NCT07511231","Angiography-Derived Physiological Indices for Outcome Prediction in Patients Undergoing OCT-Guided PCI","Prognostic Value of Angiography-Derived Physiological Indices in Patients Undergoing OCT-Guided Percutaneous Coronary Intervention","ADOPT-PCI","Inclusion Criteria:-1.Age \\>= 18 years and \\\u003C 85 years. 2.Successful stent implantation under OCT guidance. 3.Availability of at least two optimal post-PCI angiographic projections separated by \\> 25 degrees and suitable for angiography-derived physiological analysis.\n\n\\-\n\nExclusion Criteria:1.PCI of the culprit vessel for ST-segment elevation myocardial infarction (STEMI).\n\n2.Cardiogenic shock or requirement for mechanical circulatory support. 3.Life expectancy of less than 1 year. 4.History of coronary artery bypass grafting (CABG). 5.Balloon angioplasty without stent implantation. 6.Severe procedural complications, including intraprocedural death, emergency CABG, or coronary perforation.\n\n7.Target-vessel diameter \\\u003C 2.5 mm. 8.Heart failure with New York Heart Association (NYHA) class III-IV symptoms or left ventricular ejection fraction (LVEF) \\\u003C 30%.\n\n\\-","ALL","18 Years","84 Years",{"count":63,"type":64},1800,"ESTIMATED","OBSERVATIONAL","The primary design of this study is an ambispective observational cohort study. In patients undergoing successful optical coherence tomography (OCT)-guided percutaneous coronary intervention (PCI) with post-procedural angiographic images suitable for computational analysis, this study aims to evaluate the prognostic value of post-PCI angiography-derived physiological indices, specifically angiography-derived fractional flow reserve (Angio-FFR) and angiography-derived index of microcirculatory resistance (Angio-IMR), beyond conventional clinical risk factors and OCT-derived anatomical parameters. Specifically, the objectives are:\n\n1. To determine the associations of post-PCI Angio-FFR and Angio-IMR with the risk of Major Adverse Cardiovascular Events (MACE) during follow-up.\n2. To evaluate the incremental prognostic value of post-PCI Angio-FFR and Angio-IMR when added to models incorporating baseline clinical characteristics and OCT-derived anatomical parameters for predicting MACE.\n3. To assess whether the combined evaluation of Angio-FFR and Angio-IMR improves identification of residual risk after anatomically optimized, OCT-guided PCI.",[68],"Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD))",[70,21,71,72,73,74],"Optical Coherence Tomography","Angiography-derived Fractional Flow Reserve","Angiography-derived Index of Microcirculatory Resistance","Pullback Pressure Gradient","Major Adverse Cardiovascular Events","NOT_YET_RECRUITING","2026-03-30",{"date":78,"type":79},"2026-04-06","ACTUAL",{"date":81,"type":64},"2026-04",{"date":83,"type":64},"2029-07",{"name":5,"class":6},1]