[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623404":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":10,"responsibleParty":25,"collaborators":10,"id":29,"slug":30,"hasResults":31,"nctId":32,"briefTitle":33,"officialTitle":34,"acronym":35,"eligibilityCriteria":36,"healthyVolunteers":37,"sex":38,"minAge":39,"maxAge":40,"enrollmentInfo":41,"targetDuration":10,"studyType":44,"phases":10,"briefSummary":45,"conditions":46,"keywords":47,"overallStatus":52,"whyStopped":10,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":10},{"fullName":5,"class":6},"Sohag University","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Cases",null,"Patients with Ankylosing spondylitis",{"label":13,"type":10,"description":14,"interventionNames":10},"Healthy Controls","Participants Without Ankylosing spondylitis",[16,21],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"Alaa Ezzat Ahmed, Assisstant lecturer","CONTACT","00201008908404","alaa.ezzat@med.sohag.edu.eg",{"name":22,"role":18,"phone":23,"phoneExt":10,"email":24},"Dina Hamada Mohamed, Lecturer","00201119886946","dinahamada87@yahoo.com",{"type":26,"investigatorFullName":27,"investigatorTitle":28,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Alaa Ezat Ahmed","Assisstant lecturer","100623404","ankylosing-spondylitis-100623404",false,"NCT07396194","Ankylosing Spondylitis","Evaluation of the Relation Between Serum Interleukins 17, 38, 41, and HLA-B27 Gene Expression in Ankylosing Spondylitis Patients","Interleukins","Inclusion Criteria:\n\n* patients who are diagnosed clinically as ankylosing spondylitis (both active or stable), of either sex , who met the Assessment of Spondyloarthritis International Society (ASAS) criteria for axial spondyloarthritis.\n\nExclusion Criteria:\n\n* Patients with any autoimmune disorder, chronic illnesses as diabetes mellitus, acute and chronic infectious diseases, malignancy.",true,"ALL","16 Years","80 Years",{"count":42,"type":43},84,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to measure the serum level of cytokines IL-17, IL-38,IL-41, and gene expression of HLA-B27 gene in ankylosing spondylitis patients and healthy control group.\n\nThe main question it aims to answer is:\n\nDoes the disease activity, severity, serum level of cytokines (IL-17, IL-38, and IL-41) are affected by the HLA-b27 gene positivity?\n\nResearchers will compare the serum level of cytokines IL-17, IL-38,IL-41, and gene expression of HLA-B27 gene in ankylosing spondylitis patients and healthy control group to see if there significant differences in serum levels of interleukins 17, 38, 41 in AS patients and healthy control group.\n\n.",[33],[48,49,50,51],"Interleukin 17","Interleukin 38","Interleukin 41","HLA- B27 gene","NOT_YET_RECRUITING","2026-02-01",{"date":55,"type":56},"2026-02-09","ACTUAL",{"date":58,"type":43},"2026-03-01",{"date":60,"type":43},"2027-03-01",{"name":5,"class":6}]