[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100579382":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":38,"responsibleParty":63,"collaborators":25,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":67,"sex":73,"minAge":74,"maxAge":25,"enrollmentInfo":75,"targetDuration":25,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":87,"overallStatus":41,"whyStopped":25,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Heinrich-Heine University, Duesseldorf","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Individualized exercise training group","ACTIVE_COMPARATOR","Beside a guideline based anti-hypertensive therapy, patients in the intervention group will receive an individualized exercise training program 3x\u002Fweek. Exercise training will be a combination of aerobic and resistance training and is based on each patient's individual fitness level. Regular contact between exercise physiologists and patients, as well as group sessions, will help patients to maintain a regular exercise program.",[13,14],"Behavioral: Individualized exercise therapy","Behavioral: Lifestyle recommendations",{"label":16,"type":6,"description":17,"interventionNames":18},"Control group","Beside a guideline based anti-hypertensive therapy, patients in the lifestyle recommendation group will receive general recommendations such as salt reduction, higher physical activity levels and stress reduction.",[14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Individualized exercise therapy","Patients in the intervention group will receive an individualized exercise training program 3x\u002Fweek.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Lifestyle recommendations","The lifestyle recommendation group will receive general recommendations such as salt reduction, higher physical activity levels and stress reduction.",[16,9],[31,36],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Johannes Stegbauer, Prof. Dr.","CONTACT","+49 211 81 080 74","Studienzentrum-Nephrologie@med.uni-duesseldorf.de",{"name":37,"role":33,"phone":25,"phoneExt":25,"email":25},"Lukas Streese, PhD",[39],{"facility":40,"status":41,"city":42,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Universitätsklinik Düsseldorf","RECRUITING","Düsseldorf","40225","Germany","DE",{"type":47,"coordinates":48},"Point",[49,50],6.77927,51.22319,{"lat":50,"lon":49},[53,54,57,59,61],{"name":37,"role":33,"phone":34,"phoneExt":25,"email":35},{"name":55,"role":56,"phone":25,"phoneExt":25,"email":25},"Johannes Stegbauer, MD","PRINCIPAL_INVESTIGATOR",{"name":37,"role":58,"phone":25,"phoneExt":25,"email":25},"SUB_INVESTIGATOR",{"name":60,"role":58,"phone":25,"phoneExt":25,"email":25},"Claudia Schmidt, PhD",{"name":62,"role":58,"phone":25,"phoneExt":25,"email":25},"Marta Kantauskaite, MD",{"type":64,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100579382","anti-hypertensive-therapy-and-exercise-treatment-to-improve-vascular-health-in-patients-with-hypertension-100579382",false,"NCT06823570","Anti-hypertensive Therapy and Exercise Treatment to Improve Vascular Health in Patients With Hypertension.","Anti-hypertensive Therapy and Exercise Treatment to Improve Vascular Health in Patients With Hypertension. A Randomized Controlled Trial.","Antitension","Inclusion Criteria:\n\n\\- systolic hypertension grade I-II (BP values \\>140 mmHg to \\\u003C180 mmHg) without anti-hypertensive medication treatment\n\nExclusion Criteria:\n\n* no written informed consent\n* age \\\u003C18 years\n* isolated diastolic hypertension\n* medical contraindications for the exercise treatment (for example orthopedic problems or an abnormal ECG during the cardio respiratory exercise test)\n* chronic eye diseases on both eyes (for example macular degeneration or glaucoma) or high intraocular pressure (\\>20 mmHg)","ALL","18 Years",{"count":76,"type":77},60,"ESTIMATED","INTERVENTIONAL",[80],"NA","This is a prospective, monocentric, randomized controlled trial to investigate the effect of anti-hypertensive treatment and\u002For individualized exercise training intervention on blood pressure and vascular health. Furthermore the investigators want to decipher mechanisms, which contribute to vascular health by analyzing changes in metabolism and cell function in relation to vascular reaction.",[83,84,85,86],"Hypertension","Vascular Function","Fitness Testing","Metabolism Changes",[88,89,90,91,92],"cardiorespiratory fitness","retinal microcirculation","endothelial function","exercise training","lifestyle treatment","2025-03-11",{"date":95,"type":96},"2025-03-12","ACTUAL",{"date":98,"type":77},"2025-04-01",{"date":100,"type":77},"2028-12-31",{"name":5,"class":6},1]