[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100555756":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":45,"centralContacts":50,"locations":58,"responsibleParty":76,"collaborators":32,"id":78,"slug":79,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":32,"eligibilityCriteria":84,"healthyVolunteers":85,"sex":86,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":32,"studyType":92,"phases":93,"briefSummary":95,"conditions":96,"keywords":98,"overallStatus":101,"whyStopped":32,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"Cosmetique Active International","INDUSTRY",[8,17,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Group 1","EXPERIMENTAL","dermocosmetic regimen consisting in Liftactiv(® B3 serum + Liftactiv® B3 retinol night cream (all Vichy Laboratoires, France) for 6 months + Mineral 89 cream + Sunscreen UVAage Inter SPF 50+",[13,14,15,16],"Other: Liftactiv® B3 Serum","Other: Liftactiv® B3 retinol night cream","Other: Sunscreen UVAage® Inter SPF 50+","Other: Mineral 89 cream",{"label":18,"type":19,"description":20,"interventionNames":21},"Group 2","ACTIVE_COMPARATOR","hydroquinone 4% (HQ4%, Hydroquinona 40 mg\u002Fg, Germed, Brazil) for 3 months followed by the dermocosmetic regimen (Liftactiv(® B3 serum + Liftactiv® B3 retinol night cream + Mineral 89 cream + Sunscreen UVAage Inter SPF 50+) for 3 months",[13,14,15,16],{"label":23,"type":19,"description":24,"interventionNames":25},"Group 3","Combination of hydroquinone, resorcinol corticosteroid (Kligman Trio, Vitacid Plus Cream, Claredor Brazil) for 3 months followed by the dermocosmetic regimen (Liftactiv(® B3 serum + Liftactiv® B3 retinol night cream + Mineral 89 cream + Sunscreen UVAage Inter SPF 50+) for 3 months",[13,14,15,16],[27,33,37,41],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"OTHER","Liftactiv® B3 Serum","In Group 1: Application once daily for 6 months, 3-4 drops twice a day (morning before the sunscreen and evening) In Group 2 and Group 3: Application once daily, 3-4 drops twice a day (morning before the sunscreen and evening) for 3 months following HQ4% or Kligman Trio treatment.",[9,18,23],null,{"type":28,"name":34,"description":35,"armGroupLabels":36,"otherNames":32},"Liftactiv® B3 retinol night cream","In Group 1: Application once daily (morning) for 6 months In Group 2 and Group 3: During week 1, apply 2 evenings\u002Fweek. During week 2, apply every other evening. During week 3, apply every evening. During nights when retinol night cream is not applied, replace with Mineral 89 cream for 3 months following HQ4% or Kligman Trio treatment.",[9,18,23],{"type":28,"name":38,"description":39,"armGroupLabels":40,"otherNames":32},"Sunscreen UVAage® Inter SPF 50+","twice daily (morning and beginning of the afternoon)",[9,18,23],{"type":28,"name":42,"description":43,"armGroupLabels":44,"otherNames":32},"Mineral 89 cream","2 drops in the morning before sunscreen application for 6 months",[9,18,23],[46],{"name":47,"affiliation":48,"role":49},"Claire Deloche-Bensmain, PhD","La Roche Posayl Laboratoires Dermatologiques","STUDY_DIRECTOR",[51,55],{"name":47,"role":52,"phone":53,"phoneExt":32,"email":54},"CONTACT","+33 7 76 11 27 98","claire.deloche-bensmaine@loreal.com",{"name":56,"role":52,"phone":32,"phoneExt":32,"email":57},"Marianna Feiges","mariana.feiges@loreal.com",[59],{"facility":60,"status":32,"city":61,"state":32,"zip":32,"country":62,"countryCode":63,"cosmosGeoPoint":64,"geoPoint":69,"contacts":70},"CIDP","Rio de Janeiro","Brazil","BR",{"type":65,"coordinates":66},"Point",[67,68],-43.18223,-22.90642,{"lat":68,"lon":67},[71,73],{"name":72,"role":52,"phone":32,"phoneExt":32,"email":32},"Alessandro NASCIMENTO",{"name":74,"role":75,"phone":32,"phoneExt":32,"email":32},"Renato Moura, MD","PRINCIPAL_INVESTIGATOR",{"type":77,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR","100555756","anti-pigmenting-effect-of-a-routine-of-facial-products-in-subjects-with-melasma-100555756",false,"NCT06516224","Anti-pigmenting Effect of a Routine of Facial Products in Subjects With Melasma","Evaluation of the Efficacy of the Anti-pigmenting Effect of a Routine of Facial Products in Subjects With Melasma","Inclusion Criteria:\n\n* 18-65 years\n* Phototype II-V\n* 50% with sensitive skin (declarative);\n* Subjects should be affected by well defined symmetrical (on both sides of the face) epidermal melasma (clinically diagnosed under Wood's light examination) lasting since more than a year\n\nExclusion Criteria:\n\n* Subjects under topical or systemic retinoids;\n* Subjects having used topical tretinoin within 3 months or topical hydroquinone within 6 months prior to inclusion;\n* Subjects under systemic immunosuppressants and considered immune compromised\n* Subjects under active treatment of melasma (including topicals or procedures) within the last 3 months\n* Pregnant women and\u002For breastfeeding women\n* Subjects with a recent change in contraception (since less than 6 months);\n* Subjects known allergy to any component of tested product;\n* Subjects not presenting with the conditions needed to comply with the protocol;\n* Subjects without any other dermatological conditions on the face\n* Subject under menopause phase with hormonal replace therapy\n* Subjects in the initial phase, change or discontinuation of hormonal treatment (estroprogesterone, cyproteron acetate, androgenic...) in the last 3 months;\n* Subjects currently using any medication, which in the opinion of the investigator, may affect the evaluation of the study product, or place the subject at undue risk.\n* Subjects unable to give their informed consent.",true,"FEMALE","18 Years","65 Years",{"count":90,"type":91},150,"ESTIMATED","INTERVENTIONAL",[94],"NA","This 6 month, comparative study assesses the benefit of a dermocosmetic regimen (Serum B3 + B3 retinol night cream) for 6 months compared to hydroquinone 4% (the gold standard in hyperpigmentation) followed by the dermocosmetic regimen for 3 months or the Kligman Trio for 3 months followed by the dermocosmetic regimen for 3 months in adult women with melasma on the face.",[97],"Melasma",[99,100],"melasma","hyperpigmentation","NOT_YET_RECRUITING","2024-07-18",{"date":104,"type":105},"2024-07-23","ACTUAL",{"date":107,"type":91},"2024-07-15",{"date":109,"type":91},"2025-01-31",{"name":5,"class":6},1]