[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100541926":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":31,"locations":40,"responsibleParty":61,"collaborators":18,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":18,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":18,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":85,"overallStatus":43,"whyStopped":18,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Petrovsky National Research Centre of Surgery","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Ampicillin\u002Fsulbactam intervention group","EXPERIMENTAL","If a patient meets dual criteria (presepsin \\> 519,5 pg\u002Fml at the end of surgery and the absence of presepsin increase after 6 hours after the end of surgery) then switching to ampicillin\u002Fsulbactam 3 g every 6 hours at least 72 h after the surgery is done.",[13],"Drug: Ampicillin-sulbactam",{"label":15,"type":16,"description":17,"interventionNames":18},"Cefazolin","NO_INTERVENTION","If presepsin \\\u003C 519,5 pg\u002Fml at the end of surgery, cefazolin 2 g every 6 h at least 72 h p\u002Fo is continued further",null,[20],{"type":21,"name":22,"description":11,"armGroupLabels":23,"otherNames":24},"DRUG","Ampicillin-sulbactam",[9],[25],"sulmacefta, amibactam",[27],{"name":28,"affiliation":29,"role":30},"Boris Akselrod, Professor","Petrovsky NRCS","PRINCIPAL_INVESTIGATOR",[32,37],{"name":33,"role":34,"phone":35,"phoneExt":18,"email":36},"Artem Gubko, Ph.D.","CONTACT","+79684241490","gubko@artvig.ru",{"name":28,"role":34,"phone":38,"phoneExt":18,"email":39},"+79257403797","aksel@mail.ru",[41],{"facility":42,"status":43,"city":44,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Petrovsky Research National Centre of Surgery (Petrovsky NRCS)","RECRUITING","Moscow","119991","Russia","RU",{"type":49,"coordinates":50},"Point",[51,52],37.61781,55.75204,{"lat":52,"lon":51},[55,56,59],{"name":33,"role":34,"phone":35,"phoneExt":18,"email":36},{"name":57,"role":58,"phone":18,"phoneExt":18,"email":18},"Denis Guskov, Ph.D","SUB_INVESTIGATOR",{"name":60,"role":30,"phone":18,"phoneExt":18,"email":18},"Boris Akselrod, Ph.D",{"type":62,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100541926","antibacterial-tactics-based-on-presepsin-level-in-thoracic-aorta-surgery-patients-100541926",false,"NCT06336213","Antibacterial Tactics Based on Presepsin Level in Thoracic Aorta Surgery Patients","Changes in Antibacterial Therapy Based on Perioperative Dynamics of Presepsin During Reconstructive Thoracic Aorta Surgery","Inclusion Criteria:\n\nThoracic aorta aneurysm\u002Fdissection\n\nExclusion Criteria:\n\nBlood sample hemolysis","ALL","18 Years","75 Years",{"count":74,"type":75},50,"ESTIMATED","INTERVENTIONAL",[78],"NA","According to the literature, presepsin was recommended not only as an effective indicator in the diagnosis of sepsis in intensive care units, but also as a reliable prognostic marker of postoperative inflammatory processes in cardiac surgery. Previous study carried out in Petrovsky NRCS related to biomarkers in cardiac surgery and presepsin in particular showed good sensitivity in infection complications prognosis.",[81,82,83,84],"Aortic Aneurysm and Dissection","Cardiac Valve Disease","Thoracic Aortic Aneurysm","Thoracic Aortic Dissection",[86,87,88,89,90,91,92,93],"biomarkers","presepsin","complications","aortic arch","aorta","aortic aneurysm","ascending aorta","cardiac surgery","2026-01-28",{"date":96,"type":97},"2026-01-29","ACTUAL",{"date":99,"type":97},"2024-01-23",{"date":101,"type":75},"2027-02-15",{"name":5,"class":6},1]