[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100617720":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":41,"responsibleParty":58,"collaborators":26,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":26,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":26,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":84,"overallStatus":89,"whyStopped":26,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"University of Miami","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Triclosan-Braided Suture Group","EXPERIMENTAL","Patients randomized to this arm will receive triclosan-coated braided sutures for closure of the fascia. Following incision and full debridement and irrigation, the fascia will be closed with this suture. Suturing of the fascia typically takes \\~10 minutes. As this suture is absorbable, it does not have to be removed. The superficial layers of the skin will be closed with nylon suture.",[13],"Device: VICRYL™ Plus (Coated VICRYL™ Plus Antibacterial)",{"label":15,"type":16,"description":17,"interventionNames":18},"Monofilament Suture Group","ACTIVE_COMPARATOR","Patients randomized to this arm will receive monofilament sutures for closure of the fascia. Following incision and full debridement and irrigation, the fascia will be closed with this suture. Suturing of the fascia typically takes \\~10 minutes. As this suture is absorbable, it does not have to be removed. The superficial layers of the skin will be closed with nylon suture.",[19],"Device: Polydioxanone (PDS™ II ) Sterile Synthetic Absorbable Surgical Suture-Monofilament",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","VICRYL™ Plus (Coated VICRYL™ Plus Antibacterial)","Synthetic, absorbable, braided suture coated with triclosan for antimicrobial protection. Used for fascial and skin closure. Offers high tensile strength and knot security",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Polydioxanone (PDS™ II ) Sterile Synthetic Absorbable Surgical Suture-Monofilament","Absorbable, non-braided suture. Used for fascial and skin closure.",[15],[32],{"name":33,"affiliation":5,"role":34},"Colin McNamara, MD","PRINCIPAL_INVESTIGATOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Andrew R Moya, MD","CONTACT","786-856-6463","arm577@miami.edu",[42],{"facility":43,"status":26,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"University of Miami Health System","Miami","Florida","33132","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-80.19366,25.77427,{"lat":53,"lon":52},[56,57],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},{"name":33,"role":34,"phone":26,"phoneExt":26,"email":26},{"type":34,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Colin A. McNamara","Assistant Professor","100617720","antibiotic-coated-braided-suture-study-100617720",false,"NCT07322289","Antibiotic-coated Braided Suture Study","Evaluating the Use of Antibiotic-Coated Braided Sutures in Debridement, Antibiotic, and Implant Retention (DAIR) Procedures","Inclusion Criteria:\n\n* Age ≥18 years\n* Willing and able to provide informed consent\n* Primary Total Hip Arthroplasty or Total Knee Arthroplasty with Prosthetic Joint Infection Musculoskeletal Infection Society (MSIS) criteria\n* Prosthetic Joint Infection Treated with Debridement, Antibiotics, Implant Retention\n\nAcute Prosthetic Joint Infection: \\\u003C4 weeks since it was suspected\u002Fdiagnosed\n\nExclusion Criteria:\n\n* Staphylococcus aureus bacteremia\n* Mycobacterial, fungal, or parasitic infection\n* Concurrent infection needing prolonged Intravenous therapy\n* Septic shock\u002Fsystemic illness needing IV therapy\n* Patients with severe immunosuppression (ex: chemotherapy,\n\nneutropenia, HIV, steroid use\n\n* Allergy to Triclosan\n* Pregnancy\n* Prisoners","ALL","18 Years","89 Years",{"count":72,"type":73},142,"ESTIMATED","INTERVENTIONAL",[76],"NA","The purpose of this study is to evaluate whether the use of antibiotic-coated (triclosan) braided sutures is non-inferior or potentially superior to standard monofilament sutures in patients with prosthetic joint infections (PJIs) managed with the DAIR protocol. Several studies in various surgical specialties have demonstrated the effectiveness and non-inferiority of triclosan-coated braided sutures in infected surgical cases, and the study intends to transpose this idea to the management of prosthetic joint infections. Monofilament sutures are the present standard of care in any infected joint case due their lower surface area for bacterial harborization, though surgeons sacrifice mechanical integrity and comfortability with the closure in the process. By demonstrating the safety of antibiotic -coated braided sutures, surgeons will no longer have to make this compromise.",[79,80,81,82,83],"Prosthetic Joint Infection","Debridement With Prosthesis Retention","Prosthetic Joint Infections of Hip","Prosthetic Joint Infections of Knee","Suture",[85,86,87,88],"prosthetic joint infection","debridement, antibiotics, implant retention","antibiotic coated braided sutures","monofilament suture","NOT_YET_RECRUITING","2026-03-18",{"date":92,"type":93},"2026-03-23","ACTUAL",{"date":95,"type":73},"2026-07-01",{"date":97,"type":73},"2027-12-31",{"name":5,"class":6},1]