[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100396045":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":41,"centralContacts":45,"locations":54,"responsibleParty":71,"collaborators":10,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":75,"sex":80,"minAge":81,"maxAge":10,"enrollmentInfo":82,"targetDuration":85,"studyType":86,"phases":10,"briefSummary":87,"conditions":88,"keywords":93,"overallStatus":57,"whyStopped":10,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"University Hospital, Ghent","OTHER",[8,17,21],{"label":9,"type":10,"description":11,"interventionNames":12},"Amoxicillin-clavulanate",null,"Administration of amoxicillin-clavulanate as standard care therapy (4x or 6x 1g\u002Fd). Blood sampling in early and steady state dose (up to 5 samplings per dose). Collection of hemocultures, urine samples and sputum samples when possible.",[13,14,15,16],"Diagnostic Test: Blood sampling","Diagnostic Test: Sputum sample","Diagnostic Test: Hemoculture","Diagnostic Test: Urine sample",{"label":18,"type":10,"description":19,"interventionNames":20},"Piperacillin-tazobactam","Administration of piperacillin-tazobactam as standard care therapy (4x 4g\u002Fd). Blood sampling in early and steady state dose (up to 5 samplings per dose). Collection of hemocultures, urine samples and sputum samples when possible.",[13,14,15,16],{"label":22,"type":10,"description":23,"interventionNames":24},"Temocillin","Administration of temocillin as standard care therapy (2x or 3x 2g\u002Fd). Blood sampling in early and steady state dose (up to 5 samplings per dose). Collection of hemocultures, urine samples and sputum samples when possible.",[13,14,15,16],[26,31,35,38],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":10},"DIAGNOSTIC_TEST","Blood sampling","At predefined time points through a venous catheter already in place. Max. volume to be withdrawn: Maximum 4ml\u002Fsample. Maximum 10 samples\u002Fpatient.\n\nA last blood sample will be taken, if necessary, after the end of antibiotic therapy, between day 7 and day 14. Though blood results preferably will be used from available data from tests already done during standard treatment.\n\nSamples are collected in lithium-heparin tubes (without gel) and centrifuged immediately (within a maximum of 30 minutes after sampling) at room temperature: 8 minutes at 1885g.\n\nPlasma is then collected and divided in two separated labelled Eppendorf tubes 1.5 ml and immediately frozen at - 80 °C. If this is not immediately possible, tubes are frozen at - 20 °C and at regular time points transferred to a freezer at - 80 °C (minimum twice a day).",[9,18,22],{"type":27,"name":32,"description":33,"armGroupLabels":34,"otherNames":10},"Sputum sample","Bacteriological specimen, such as blood cultures, urine samples, sputum ea., which are usually collected in every patient according to standard care will be retained. If there is bacterial growth, MIC's will be calculated on these strains for study purpose.",[9,18,22],{"type":27,"name":36,"description":33,"armGroupLabels":37,"otherNames":10},"Hemoculture",[9,18,22],{"type":27,"name":39,"description":33,"armGroupLabels":40,"otherNames":10},"Urine sample",[9,18,22],[42],{"name":43,"affiliation":5,"role":44},"Tania Desmet, Dr.","PRINCIPAL_INVESTIGATOR",[46,51],{"name":47,"role":48,"phone":49,"phoneExt":10,"email":50},"Peter De Paepe, Prof. Dr.","CONTACT","003293325211","peter.depaepe@uzgent.be",{"name":43,"role":48,"phone":52,"phoneExt":10,"email":53},"003293321559","tania.desmet@uzgent.be",[55],{"facility":56,"status":57,"city":58,"state":10,"zip":59,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":68},"University Hospital Ghent","RECRUITING","Ghent","9000","Belgium","BE",{"type":63,"coordinates":64},"Point",[65,66],3.71667,51.05,{"lat":66,"lon":65},[69,70],{"name":47,"role":48,"phone":49,"phoneExt":10,"email":50},{"name":43,"role":48,"phone":52,"phoneExt":10,"email":53},{"type":72,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100396045","antibiotic-dosing-in-geriatric-patients-at-the-emergency-department-100396045",false,"NCT04436991","Antibiotic Dosing in Geriatric Patients At the Emergency Department","AGED","Inclusion Criteria:\n\n* Patients presenting at the emergency department and later on admitted to the geriatric department\n* Patient age 75 years or older\n* Patients with geriatric profile according to KATZ scale, G8 screening test or CIRS score.\n* Patient receiving antibiotic treatment (amoxicillin-clavulanate, piperacillin-tazobactam)\n* Intravenous access available for blood sampling. For measurement of the peak concentration an intravenous access other than the drug infusion line is required.\n\nExclusion Criteria:\n\n* Admission to other units than the geriatric department incl. the ICU.\n* Absence of informed consent\n* Known hypersensitivity to beta-lactam antibiotics\n* Patients who received oral amoxicillin-clavulanate prior to admission will not be included in the iv. amoxicillin-clavulanate group.","ALL","75 Years",{"count":83,"type":84},180,"ESTIMATED","2 Weeks","OBSERVATIONAL","In this pilot study, we will investigate whether - with the current dosing regimens, used in the Ghent University Hospital - pharmacodynamic targets regarding beta-lactam antibiotics (more specific Amoxicilline-Clavulanate, Piperacillin-Tazobactam and Temocillin) are attained in frail patients admitted to the geriatric department.",[89,90,91,92],"Elderly Infection","Frailty","Frail Elderly Syndrome","Infection, Bacterial",[94,95,96,97,98],"amoxicillin","piperacillin-tazobactam","temocillin","pharmacokinetics","pharmacodynamics","2024-09-05",{"date":101,"type":102},"2024-09-19","ACTUAL",{"date":104,"type":102},"2018-01-03",{"date":106,"type":84},"2025-01",{"name":5,"class":6},1]