[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100533211":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":20,"locations":26,"responsibleParty":57,"collaborators":10,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":61,"sex":67,"minAge":68,"maxAge":10,"enrollmentInfo":69,"targetDuration":10,"studyType":72,"phases":10,"briefSummary":73,"conditions":74,"keywords":79,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Medical University Innsbruck","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients after cardiovascular surgery who received anticoagulation",null,"The investigated population comprises all patients after cardiovascular surgery who received anticoagulation. Subgroup analyses based on the level of inflammation, delirium, anticoagulation, and others will be conducted.",[13],"Diagnostic Test: Anticoagulation monitoring",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","Anticoagulation monitoring","Evaluation of different monitoring modalities to find the most appropriate anticoagulation monitoring tool for UFH therapy",[9],[21],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Sasa Rajsic, MD, PhD","CONTACT","004367763004447","sasa.rajsic@tirol-kliniken.at",[27],{"facility":5,"status":28,"city":29,"state":30,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"RECRUITING","Innsbruck","Tyrol","6020","Austria","AT",{"type":35,"coordinates":36},"Point",[37,38],11.39454,47.26266,{"lat":38,"lon":37},[41,42,44,47,49,51,53,55],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},{"name":22,"role":43,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"name":45,"role":46,"phone":10,"phoneExt":10,"email":10},"Barbara Sinner, Prof. Dr.","SUB_INVESTIGATOR",{"name":48,"role":46,"phone":10,"phoneExt":10,"email":10},"Axel Kleinsasser, Univ.Doz.Dr.",{"name":50,"role":46,"phone":10,"phoneExt":10,"email":10},"Corinna Velik-Salchner, Priv.Doz.Dr.",{"name":52,"role":46,"phone":10,"phoneExt":10,"email":10},"Benedikt Treml, Priv.Doz.Dr.",{"name":54,"role":46,"phone":10,"phoneExt":10,"email":10},"Nicole Innerhofer, MD",{"name":56,"role":46,"phone":10,"phoneExt":10,"email":10},"Christine Eckhardt, MD, PhD",{"type":58,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100533211","anticoagulation-and-inflammation-monitoring-in-patients-after-heart-and-vascular-interventions-100533211",false,"NCT06222866","Anticoagulation and Inflammation Monitoring in Patients After Heart and Vascular Interventions","Anticoagulation and Inflammation Monitoring in Patients After Heart and Vascular Interventions: Prospective Observational Study","PAC-AIM","Inclusion Criteria:\n\n* Age: \\> 17 years\n* Informed written consent\n* Scheduled for cardiac intervention where the use of UFH is expected (elective surgery)\n* Scheduled for vascular intervention when the need for perioperative anticoagulation is expected (elective surgery)\n* Patients receiving ECMO support\n\nExclusion Criteria:\n\n* Patients that are known to be pregnant\n* Known participation in other interventional clinical trial","ALL","18 Years",{"count":70,"type":71},400,"ESTIMATED","OBSERVATIONAL","The goal of this prospective observational study is to evaluate the most appropriate anticoagulation monitoring tool for unfractionated heparin (UFH), by comparison of different monitoring modalities in relation to adverse events occurrence (thrombosis\u002Fbleeding).\n\nThe main study questions are:\n\n* What is the most appropriate anticoagulation monitoring tool (ACT, aPTT, viscoelastic tests (ROTEM), and anti-Xa) for UFH\n* What is the incidence of adverse events associated with anticoagulation and inflammation after heart and vascular interventions\n* Is there an association of available anticoagulation thresholds and monitoring tests with bleeding and\u002For thrombosis occurrence\n* Is there an association of inflammation with delirium\n\nSecondary study objectives include:\n\n* Association of anticoagulation levels as measured by ACT, aPTT, viscoelastic tests (ROTEM), and anti-factor-Xa with adverse events\n* Correlation of each anticoagulation monitoring test with the UFH anti-Xa measurement\n* Correlation of each anticoagulation monitoring test with another (ACT, aPTT, ROTEM, anti-F-Xa) and the amount of blood loss post surgery\n* The incidence of UFH-rebound effect and the need for protamine application\n* Association of inflammation and increased \u002F reduced need for anticoagulation titration\n* Correlation of anticoagulation dosing with anticoagulation monitoring tests and adverse events\n* The association of inflammation with adverse events\n* The association and impact of inflammation on measured levels of anticoagulation with available tests\n* Influence of anticoagulation on mortality\n* Incidence of ECMO support\n* Incidence of delirium (hypoactive and hyperactive) and correlation with vital (newly onset postoperative atrial fibrillation amongst others) and laboratory parameters, including, and pre-existing neurological disorders",[75,76,77,78],"Heart Surgery","Vascular Surgery","Delirium","Hyperinflammatory Syndrome",[80,81,82,83,84,77,85],"cardiac surgery","vascular surgery","Anticoagulation","Adverse Events","Monitoring","Inflammation","2024-11-25",{"date":88,"type":89},"2024-11-26","ACTUAL",{"date":91,"type":89},"2024-06-25",{"date":93,"type":71},"2026-12-01",{"name":5,"class":6},1]