[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100557061":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":29,"centralContacts":41,"locations":48,"responsibleParty":65,"collaborators":46,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":46,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":46,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":51,"whyStopped":46,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Tanta University","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Group 1: Chlorohexidine (CHX) gel.","ACTIVE_COMPARATOR","Application of Chlorohexidine intracanal medication in secondry endodontic infection cases",[13],"Other: antimicrobial efficacy of nano based intracanal medications on Enterococcus faecalis count reduction in secondary endodontic infection cases.",{"label":15,"type":10,"description":16,"interventionNames":17},"Group 2: Chlorohexidine loaded by silver nanoparticles (Ag-np) gel.","Application of chlorohexidine loaded by silver nanoparticles (Ag-np) gel intracanal medication in secondry endodontic infection cases",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Group 3: Triple antibiotic-loaded chitosan nanoparticles (tachnp) gel.","Application of triple antibiotic-loaded chitosan nanoparticles (tachnp) gelintracanal medication in secondry endodontic infection cases",[13],[23],{"type":6,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"antimicrobial efficacy of nano based intracanal medications on Enterococcus faecalis count reduction in secondary endodontic infection cases.","The paper points of three samples (S1, S2, and S3) will be placed each in a sterile falcon tube containing 1ml of brain heart infusion and labeled according to the type of intracanal medication used. Samples will be homogenized by the vortex and and one micron of each sample will be cultured on Bile Esculin Agar for E. faecalis.\n\nThe plate will be labeled as the tube of the same sample and incubated at 37οC for 24-48 h and then after incubation, the total numbers of E.faecalis will be counted and calculated to get the colony forming units (CFU\u002Fml).",[9,15,19],[28],"Microbiological count",[30,34,38],{"name":31,"affiliation":32,"role":33},"Abeer Darrag, Phd","Professor of Endodontics","PRINCIPAL_INVESTIGATOR",{"name":35,"affiliation":36,"role":37},"Dina Ali, phd","Lecturer of Endodontics","STUDY_DIRECTOR",{"name":39,"affiliation":40,"role":33},"Radwa Abd Elmotaleb Eissa, phd","Ass.professor of Microbiology",[42],{"name":43,"role":44,"phone":45,"phoneExt":46,"email":47},"Ibrahim Ali, bachelor","CONTACT","+201021294204",null,"ibrahim3lii1995@gmail.com",[49],{"facility":50,"status":51,"city":52,"state":46,"zip":46,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Faculty of Dentistry","RECRUITING","Tanta","Egypt","EG",{"type":56,"coordinates":57},"Point",[58,59],31.00192,30.78847,{"lat":59,"lon":58},[62],{"name":63,"role":44,"phone":64,"phoneExt":46,"email":46},"Ahmed salim","+201559959130",{"type":33,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":46,"oldOrganization":46},"Ibrahim Ali Eissa","doctor","100557061","antimicrobial-efficacy-of-nano-based-icm-on-ef-100557061",false,"NCT06533215","Antimicrobial Efficacy of Nano-Based ICM on E.F","Antimicrobial Efficacy of Nano-Based Intracanal Medications on Enterococcus Faecalis","Inclusion Criteria:\n\n* Single rooted, single canal premolar teeth.\n* Teeth indicated for non-surgical root canal retreatment.\n* Teeth have signs and\u002For symptoms of post-treatment disease manifested by recurrent acute and\u002For chronic periapical abscess.\n* Teeth have clinical signs and symptoms of endodontic failure as sensitivity to percussion, pain, swelling or fistula.\n* Teeth with radiographic features of endodontic failure as persistent periapical lesion or widening of periodontal ligament.\n* Symptomatic or asymptomatic teeth with short root canal filling indicated for prosthetic restoration\n\nExclusion Criteria:\n\n* Patients with any systemic diseases.\n* Pregnant or lactating patients.\n* Immunocompromised patients.\n* Non-restorable tooth.\n* Calcified root canal.\n* Teeth with root fracture.\n* Teeth with periodontal pocket deeper than 4mm.\n* Teeth have procedural error like ledge, broken instrument, or perforation",true,"ALL","19 Years","60 Years",{"count":80,"type":81},30,"ESTIMATED","INTERVENTIONAL",[84],"NA","This in-vivo study aims to evaluate the antimicrobial effect of nano based intracanal medications (Triple antibiotic-loaded chitosan nanoparticles and chlorohexidine loaded by silver nanoparticles) on Enterococcus faecalis count reduction in secondary endodontic infection cases.",[87,88,89],"Enterococcus Faecalis Infection","Endodontically Treated Teeth","Endodontic Disease",[91,92,93],"intracanal medication","Enterococcus Faecalis","secondary endodontic infection cases.","2024-07-30",{"date":96,"type":97},"2024-08-01","ACTUAL",{"date":99,"type":97},"2024-01-02",{"date":101,"type":81},"2025-03-02",{"name":5,"class":6},1]