[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100285516":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":28,"centralContacts":32,"locations":42,"responsibleParty":62,"collaborators":64,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":72,"sex":78,"minAge":79,"maxAge":25,"enrollmentInfo":80,"targetDuration":25,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":25,"overallStatus":45,"whyStopped":25,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Université de Montréal","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Cefazolin","ACTIVE_COMPARATOR","During an open shoulder surgery, the Cefazolin will be administered to some patient. The Cefazolin is a first generation cephalosporin. It is a beta lactam which targets gram positive cocci and some gram negative bacilli. The INESS Antibiotic Prophylaxis in Orthopedic Guide recommends the use of Cefazolin at induction for all orthopaedic procedure with implantation of internal fixation device. The dosage is 2g intravenous if the patient weights less than 120kg or 3g if the patient weights more than 120kg. The dose should be repeated if the procedure lasts for more than three hours or if the blood loss is greater than 1500mL.",[13],"Drug: Cefazolin",{"label":15,"type":16,"description":17,"interventionNames":18},"Ceftriaxone","EXPERIMENTAL","During an open shoulder surgery, the Ceftriaxone will be administered to some patient. The Ceftriaxone is a third generation cephalosporin. It targets gram positive cocci such as staphylococcus and streptococcus, gram negative bacilli and some anaerobes, including P. acnes. The prophylactic dose is of 2g IV given a minimum of 30 minutes prior to skin incision. It is effective 12h so no other dose is needed during surgery.",[19],"Drug: Ceftriaxone",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Antibiotic that will be give before a Trauma or elective open shoulder surgery",[9],null,{"type":22,"name":15,"description":23,"armGroupLabels":27,"otherNames":25},[15],[29],{"name":30,"affiliation":5,"role":31},"Dominique Rouleau, MD","PRINCIPAL_INVESTIGATOR",[33,38],{"name":30,"role":34,"phone":35,"phoneExt":36,"email":37},"CONTACT","514-338-2222","3427","dominique_rouleau@yahoo.ca",{"name":39,"role":34,"phone":35,"phoneExt":40,"email":41},"Karine Tardif","3465","karinetardif2@gmail.com",[43],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Hôpital du Sacré-Cœur de Montréal","RECRUITING","Montreal","Quebec","H4J 1C5","Canada","CA",{"type":52,"coordinates":53},"Point",[54,55],-73.58781,45.50884,{"lat":55,"lon":54},[58,61],{"name":59,"role":34,"phone":35,"phoneExt":60,"email":37},"Dominique Rouleau","2050",{"name":39,"role":34,"phone":35,"phoneExt":40,"email":41},{"type":31,"investigatorFullName":59,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Orthopaedic surgeon",[65,68],{"name":66,"class":67},"Stryker Trauma and Extremities","INDUSTRY",{"name":69,"class":6},"Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal","100285516","antimicrobial-prophylaxis-for-skin-colonization-with-propionibacterium-acnes-in-primary-open-shoulder-surgery-100285516",false,"NCT02996656","Antimicrobial Prophylaxis for Skin Colonization With Propionibacterium Acnes in Primary Open Shoulder Surgery","Antimicrobial Prophylaxis for Skin Colonization With Propionibacterium Acnes in Primary Open Shoulder Surgery: A Double Blinded Randomized Controlled Trial","PAPA","Inclusion Criteria:\n\n* 18 years and older\n* Male or female\n* Presenting normal skin on the shoulder aria\n\nExclusion Criteria:\n\n* Used antibiotics or treated their skin with antibiotic gel, alcohol gel or cream or acne treatment in the last three months\n* Active infection at the surgical site or anywhere\n* Affected shoulder previously received radiotherapy\n* Allergic to one of the antimicrobial prophylaxis used\n* Open fracture\n* Life threatening or a limb threatening pathology\n* Liver or kidney failure","ALL","18 Years",{"count":81,"type":82},88,"ESTIMATED","INTERVENTIONAL",[85],"NA","INESS Antibiotic Prophylaxis in Orthopedic Guide recommends the use of Cefazolin at induction for all orthopaedic procedure with implantation of internal fixation device. With the increasing rate of identified P. acnes shoulder surgery infection despite the use of recommended skin preparation and preoperative prophylactic antibiotics, a question arises; Is Cefazolin the most effective prophylactic antibiotic for shoulder surgery? The objective of this study is to determine if Ceftriaxone is superior to Cefazolin as a prophylactic antibiotic for skin colonization with P. acnes in primary shoulder surgery",[88],"Propionibacterium Infection","2026-04-27",{"date":91,"type":92},"2026-05-01","ACTUAL",{"date":94,"type":25},"2016-12",{"date":96,"type":82},"2026-12",{"name":5,"class":6},1]