[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100448862":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":44,"responsibleParty":61,"collaborators":25,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":25,"enrollmentInfo":72,"targetDuration":25,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":25,"overallStatus":47,"whyStopped":25,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Assistance Publique - Hôpitaux de Paris","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental group","EXPERIMENTAL","Antimicrobial stewardship based on daily clinical assessment of clinical cure (experimental group). Discontinuation of antibiotic therapy antibiotics if criterions of clinical cure (regression of tracheal secretions, regression of temperature, improvement of PaO2\u002FFiO2 ratio, absence of hemodynamic failure) of confirmed VAP are met. In the intervention group, intensivists will perform clinical assessment daily in order to decide on the pursuit or discontinuation of antibiotic therapy.",[13],"Drug: Antimicrobial Stewardship",{"label":15,"type":6,"description":16,"interventionNames":17},"Control group","Standard management: duration of appropriate antibiotic therapy for confirmed VAP according to guidelines. In the control group, intensivists will perform clinical assessment daily, but a minimum duration of 7 days, as highly recommended of antibiotic therapy will be mandatory whatever the clinical cure.",[18],"Drug: Standard management",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Antimicrobial Stewardship","Antimicrobial stewardship based on daily clinical assessment of clinical cure. Discontinuation of appropriate antibiotic therapy antibiotics if criteria of clinical cure of confirmed pneumonia are met. Intensivists will perform clinical assessment daily in order to decide on the pursuit or discontinuation of antibiotic therapy.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Standard management","Standard management: duration of appropriate antibiotic for confirmed pneumonia fixed for 7 days according to guidelines. In the control group, intensivists will perform clinical assessment daily, but the antibiotic will not be discontinued until 7 days whatever the clinical cure.",[15],[31],{"name":32,"affiliation":33,"role":34},"Arnaud Foucrier","APHP","PRINCIPAL_INVESTIGATOR",[36,40],{"name":32,"role":37,"phone":38,"phoneExt":25,"email":39},"CONTACT","+33 1 40 87 52 33","arnaud.foucrier@aphp.fr",{"name":41,"role":37,"phone":42,"phoneExt":25,"email":43},"Emmanuel Weiss","+33 1 40 87 59 11","emmanuel.weiss@aphp.fr",[45],{"facility":46,"status":47,"city":48,"state":25,"zip":25,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Foucrier","RECRUITING","Clichy-sous-Bois","France","FR",{"type":52,"coordinates":53},"Point",[54,55],2.55323,48.9102,{"lat":55,"lon":54},[58],{"name":32,"role":37,"phone":59,"phoneExt":60,"email":39},"140875911","33",{"type":62,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100448862","antimicrobial-stewardship-for-ventilator-associated-pneumonia-in-intensive-care-100448862",false,"NCT05124977","Antimicrobial Stewardship For Ventilator Associated Pneumonia in Intensive Care","ASPIC","Inclusion Criteria:\n\n* Diagnosis of microbiologically confirmed of first episode of VAP\n* Initial appropriate antibiotic therapy (whether empirical or not)\n* Written informed consent from the patient or a legal representative if appropriate. If absence of a legal representative the patient may be included in emergency procedure\n\nDefinitive diagnosis of pneumonia (in agreement with international guidelines) is defined by association:\n\n* Patient under MV\\>48 hours at the time of the microbiological sampling\n* New pulmonary infiltrate of which an infectious origin is strongly suspected\n* Worsening oxygenation\n* Have the following clinical criteria within the 24 hours prior to the first dose of antibiotic therapy\n\n  * Purulent tracheal secretions\n  * And at least 1 of the following : documented fever (body temperature \\>38,3°C) or hypothermia (body temperature \\\u003C35°C) or white blood cell (WBC) count \\>10,000 cells\u002Fmm3 or \\\u003C4,000 cells\u002Fmm3\n* Microbiological criteria (positive quantitative culture of a lower respiratory tract (LRT): bronchoalveolar lavage fluid (BAL) (significant threshold ≥10\\^4 colony-forming units\u002FmL) or plugged telescopic catheter (PTC) (significant threshold ≥ 10\\^3 colony-forming units\u002FmL) or quantitative endotracheal aspirate (ETA) distal pulmonary secretion samples (significant threshold ≥10\\^5 colony-forming units\u002FmL)\n\nExclusion Criteria:\n\n* Patient under selective decontamination of the digestive tract\n* Duration of antibiotic therapy prior to inclusion \\> 72h (for any reason) appropriate to the germs found in the bacterial documentation of the first episode of VAP\n* Inclusion in another interventional study concerning antimicrobial strategies\n* Moribund (IGS II\\>80)\n* Thoracic trauma with Abbreviated Injury Scale (AIS) thorax ≥ 3\n* Severely immunocompromised patients (such as congenital immunodeficiency, neutropenia (\\\u003C1leucocyte\u002Fml or \\\u003C0.5 neutrophil\u002Fml) or acute hematologic malignancy or stem cell transplant, HIV infection with CD4 count below 200\u002Fmm3\n* Patients undergoing immunosuppressive therapy and long term corticotherapy \\> 0.5 mg\u002Fkg\n* VAP due to: Pseudomonas aeruginosa, Carbapenem-resistant Acinetobacter spp, Carbapenem-resistant Enterobacteriaceae\n* VAP occurring in the context of co-infection of COVID-19 or other viral pneumonia (confirmed by RT-PCR)\n* Patients with empyema, necrotizing and abscessed pneumonia\n* Patients requiring extracorporeal oxygen therapy (ECMO), either veno-venous or veno-arterial\n* Pregnant women\n* No health insurance coverage","ALL","18 Years",{"count":73,"type":74},590,"ESTIMATED","INTERVENTIONAL",[77],"NA","Increasing emergence of multidrug resistant (MDR) bacteria worldwide is now considered one of the most urgent threats to global health. The association between increase of antibiotics consumption and resistance emergence has been well documented for all patients admitted to the Intensive care unit (ICU) who received antibiotic treatment and for patients treated for ventilator associated pneumonia (VAP).\n\nReduction of use of antibiotics is a major point in the war against antimicrobial resistance. VAP is the first cause of healthcare-associated infections in ICU and more than half of antibiotics prescriptions in ICU are due to VAP.\n\nOnce the diagnosis of pneumonia under MV has been made, initiation of antibiotic treatment must be prompt but there is no clear consensus on its duration. In the case of a good clinical response to treatment, it has been shown in some situations that short course antibiotics can be effective without side effects and antimicrobial stewardship initiatives can be applied successfully and effectively to the management of Community Acquired Pneumonia (CAP).\n\nThe hypothesis is that an antimicrobial stewardship is possible in the treatment of VAP with no increase in the rate of all-cause mortality, treatment failure or occurrence of new episode of pneumonia.\n\nThe objective is to investigate whether an antimicrobial stewardship for VAP based on daily assessment of clinical cure and antimicrobial discontinuation, if it is obtained, would be non-inferior in terms of all-cause mortality, treatment failure or occurrence of new episode of pneumonia.\n\nThis study will be a prospective, national multicenter (31 centers), phase III, comparative randomized (1:1), single-blinded clinical trial comparing two management strategies of treatment of pneumonia on the basis of two parallel arms:\n\nExperimental group: Antimicrobial stewardship based on daily clinical assessment of clinical cure.\n\nControl group: standard management: duration of appropriate antibiotic therapy for confirmed VAP according to guidelines.",[80],"Ventilator Associated Pneumonia","2025-05-23",{"date":83,"type":84},"2025-05-25","ACTUAL",{"date":86,"type":84},"2022-09-20",{"date":88,"type":74},"2026-03",{"name":5,"class":6},1]