[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616211":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":88,"collaborators":25,"id":90,"slug":91,"hasResults":92,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":92,"sex":98,"minAge":99,"maxAge":25,"enrollmentInfo":100,"targetDuration":25,"studyType":103,"phases":104,"briefSummary":106,"conditions":107,"keywords":109,"overallStatus":38,"whyStopped":25,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":121},{"fullName":5,"class":6},"China National Center for Cardiovascular Diseases","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Traditional off-pump coronary artery bypass grafting (Ao-SVG)","ACTIVE_COMPARATOR","Off-pump CABG with proximal saphenous vein graft (SVG) anastomoses constructed on the ascending aorta using a partial-occlusion (side-biting) clamp.",[13],"Procedure: Conventional off-pump CABG with partial clamping of the ascending aorta (Ao-SVG)",{"label":15,"type":16,"description":17,"interventionNames":18},"Aortic no-touch coronary artery bypass grafting (RIMA-SVG)","EXPERIMENTAL","Aortic no-touch off-pump CABG in which the saphenous vein graft (SVG) is anastomosed to the right internal mammary artery (RIMA) as a composite graft, avoiding any clamping or manipulation of the ascending aorta.",[19],"Procedure: Aortic no-touch coronary artery bypass grafting (RIMA-SVG)",[21,26],{"type":22,"name":15,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Ascending aortic no-touch CABG with saphenous vein graft (SVG) anastomosed to the right internal mammary artery (RIMA)",[15],null,{"type":22,"name":27,"description":11,"armGroupLabels":28,"otherNames":25},"Conventional off-pump CABG with partial clamping of the ascending aorta (Ao-SVG)",[9],[30],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},"Lianxin Chen","CONTACT","01088322265","chenlianx1@163.com",[36,51,62,75],{"facility":37,"status":38,"city":39,"state":25,"zip":25,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Fuwai Hospital Chinese Academy of Medical Sciences","RECRUITING","Beijing","China","CN",{"type":43,"coordinates":44},"Point",[45,46],116.39723,39.9075,{"lat":46,"lon":45},[49],{"name":50,"role":32,"phone":33,"phoneExt":25,"email":34},"Chen",{"facility":52,"status":53,"city":39,"state":25,"zip":25,"country":40,"countryCode":41,"cosmosGeoPoint":54,"geoPoint":56,"contacts":57},"Peking University First Hospita","NOT_YET_RECRUITING",{"type":43,"coordinates":55},[45,46],{"lat":46,"lon":45},[58],{"name":59,"role":32,"phone":60,"phoneExt":25,"email":61},"Wang","+86 13522784537","wj0463@sina.cn",{"facility":63,"status":53,"city":64,"state":25,"zip":25,"country":40,"countryCode":41,"cosmosGeoPoint":65,"geoPoint":69,"contacts":70},"Qingdao Cardiovascular Hospital","Qingdao",{"type":43,"coordinates":66},[67,68],120.38042,36.06488,{"lat":68,"lon":67},[71],{"name":72,"role":32,"phone":73,"phoneExt":25,"email":74},"Feng","+86 13964265680","fengzunyi@163.com",{"facility":76,"status":53,"city":77,"state":25,"zip":25,"country":40,"countryCode":41,"cosmosGeoPoint":78,"geoPoint":82,"contacts":83},"Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen","Shenzhen",{"type":43,"coordinates":79},[80,81],114.0683,22.54554,{"lat":81,"lon":80},[84],{"name":85,"role":32,"phone":86,"phoneExt":25,"email":87},"Nie","+86 13701176101","wangsymd@126.com",{"type":89,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100616211","aortic-no-touch-vs-partial-aortic-clamping-in-off-pump-cabg-100616211",false,"NCT07302659","Aortic No-Touch vs Partial Aortic Clamping in Off-Pump CABG","Surgical Techniques to Prevent Perioperative Neurologic Complications in Patients Undergoing Coronary Artery Bypass Grafting","PROTECT-CABG","Inclusion Criteria:\n\n* Adult patients (\\>18 years old) with multivessel coronary artery disease who are scheduled to undergo isolated off-pump coronary artery bypass grafting and who provide informed consent to participate in this study.\n\nExclusion Criteria:\n\n* Indications for cardiopulmonary bypass surgery (or no contraindications to on-pump surgery);\n* Great saphenous vein is unsuitable for use as a graft conduit;\n* Subclavian artery stenosis or occlusion, or any contraindication to the use of the internal mammary artery as a graft conduit;\n* History of previous cardiac surgery;\n* Emergency surgery;\n* Inability to apply an aortic clamp due to severe ascending aortic calcification;\n* Expected inability to tolerate MRI or contraindications to MRI (e.g., known intolerance to MRI, an implanted permanent pacemaker, or an anticipated need for permanent pacemaker implantation);\n* Inability to complete neurocognitive assessment due to language barriers or visual\u002Fhearing impairment.","ALL","18 Years",{"count":101,"type":102},380,"ESTIMATED","INTERVENTIONAL",[105],"NA","To explore surgical strategies that reduce perioperative neurologic complications in cardiovascular surgery, with the aim of improving perioperative outcomes and quality of life while reducing the socioeconomic burden. Specifically:\n\nThis multicenter, randomized controlled clinical trial will evaluate the benefits of a novel aortic no-touch technique in reducing perioperative silent brain infarction(SBI) among patients undergoing surgical treatment for coronary artery disease. The findings are expected to provide a safe and effective myocardial revascularization strategy for individuals at high risk of cerebral ischemia.",[108],"Coronary Artery Bypass Graft (CABG)",[110,111],"coronary artery bypass graft","Silent Brain Infarction","2026-04-09",{"date":114,"type":115},"2026-04-14","ACTUAL",{"date":117,"type":115},"2026-03-10",{"date":119,"type":102},"2028-06-30",{"name":5,"class":6},4]