[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100494209":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":29,"locations":35,"responsibleParty":52,"collaborators":54,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":59,"sex":65,"minAge":10,"maxAge":10,"enrollmentInfo":66,"targetDuration":10,"studyType":69,"phases":10,"briefSummary":70,"conditions":71,"keywords":75,"overallStatus":38,"whyStopped":10,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"IRCCS Policlinico S. Donato","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Syndromic TAA",null,"Subjets with clinical or genetic diagnosis of syndromic thoracic aortic aneurysms",[13],"Device: Pulsotonometry",{"label":15,"type":10,"description":16,"interventionNames":17},"Non-syndromic TAA","Subjets without clinical or genetic diagnosis of syndromic thoracic aortic aneurysms",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DEVICE","Pulsotonometry","Evaluation of arterial stiffness",[15,9],[25],{"name":26,"affiliation":27,"role":28},"Alessandro Pini","Cardiovascular-Gentic Centre, IRCCS Policlinico San Donato","PRINCIPAL_INVESTIGATOR",[30],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},"Alessandro Pini, MD","CONTACT","+390252774705","alessandro.pini@grupposandonato.it",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"IRCCS Policlinico San Donato","RECRUITING","San Donato Milanese","Lombardy","20097","Italy","IT",{"type":45,"coordinates":46},"Point",[47,48],9.26838,45.41047,{"lat":48,"lon":47},[51],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},{"type":28,"investigatorFullName":26,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Principal Investigator",[55],{"name":56,"class":6},"Istituto Auxologico Italiano","100494209","aortic-stiffness-in-patients-with-genetic-aortopathies-100494209",false,"NCT05715203","Aortic Stiffness in Patients With Genetic Aortopathies","Aortic Stiffness in Patients With Genetic Aortopathies: Intervention Analysis","PULSEWAVE","Inclusion Criteria:\n\n* Subjects with AAT, either syndromic or non syndromic;\n* Signed informed consent\n\nExclusion Criteria:\n\n* Patients with early menopause and\u002For osteoporosis, rheumatic heart disease and active malignant tumours;\n* Patients with acute and chronic inflammatory conditions such as: chronic liver disease, chronic renal insufficiency and diseases affecting the thyroid system;\n* Seropositivity to HIV, HCV, HBsAg and SARS-CoV-2;\n* Pregnancy","ALL",{"count":67,"type":68},250,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to study arterial stiffness in patients with thoracic ascending aortic aneurysms (TAA), either syndromic or non-syndromic. The main questions it aims to answer are:\n\n* Stratification of aortic risk based on arterial stiffness; Compare measurements with morphological and haemodynamic features of the ascending thoracic aorta.\n\nParticipants will be asked to undergo non-invasive evaluation of blood pressure and arterial stiffness.",[72,73,74],"Rare Diseases","Aortic Stiffness","Connective Tissue Defect",[76,77,78],"arterial stiffness","Ascending aortic aneurysm","pulse wave velocity","2025-09-08",{"date":81,"type":82},"2025-09-10","ACTUAL",{"date":84,"type":82},"2023-02-15",{"date":86,"type":68},"2025-12-31",{"name":5,"class":6},1]