[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638469":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":10,"centralContacts":29,"locations":35,"responsibleParty":49,"collaborators":10,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":55,"sex":61,"minAge":62,"maxAge":10,"enrollmentInfo":63,"targetDuration":10,"studyType":66,"phases":10,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":37,"whyStopped":10,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Singapore General Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Planned NOSE Extraction",null,"Patients undergoing planned natural orifice specimen extraction (NOSE), including transanal or transvaginal extraction, during elective minimally invasive colorectal surgery.",[13],"Procedure: Natural Orifice Specimen Extraction",{"label":15,"type":10,"description":16,"interventionNames":17},"Planned Transabdominal Extraction","NOSE-eligible patients undergoing planned transabdominal specimen extraction during elective minimally invasive colorectal surgery.",[18],"Procedure: Transabdominal Specimen Extraction",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"PROCEDURE","Natural Orifice Specimen Extraction","Specimen extraction through a natural orifice, including transanal or transvaginal extraction, during minimally invasive colorectal surgery.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"Transabdominal Specimen Extraction","Specimen extraction through an abdominal incision during minimally invasive colorectal surgery.",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},"Isaac Seow-En, MBBS, FRCSEd","CONTACT","+6563213853","isaac.seow.en@singhealth.com.sg",[36],{"facility":5,"status":37,"city":38,"state":10,"zip":39,"country":38,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"RECRUITING","Singapore","169608","SG",{"type":42,"coordinates":43},"Point",[44,45],103.85007,1.28967,{"lat":45,"lon":44},[48],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},{"type":50,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Isaac Seow En","Senior Consultant, Department of Colorectal Surgery, Singapore General Hospital","100638469","ap-noses-a-prospective-multicentre-registry-of-natural-orifice-specimen-extraction-in-minimally-invasive-colorectal-surgery-100638469",false,"NCT07615036","AP-NOSES: A Prospective Multicentre Registry of Natural Orifice Specimen Extraction in Minimally Invasive Colorectal Surgery","AP-NOSES: A Prospective, Multicentre Registry of Natural Orifice Specimen Extraction in Minimally Invasive Colorectal Surgery Across the Asia-Pacific Region","AP-NOSES","Inclusion Criteria:\n\n* Age 21 years or older\n* Elective minimally invasive colorectal resection (laparoscopic or robotic intent)\n* Planned intact specimen extraction\n* Eligible for natural orifice specimen extraction (NOSE) or transabdominal specimen extraction according to study protocol\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Emergency colorectal surgery\n* Planned transanal total mesorectal excision (TaTME)\n* Planned ultralow anterior resection with planned anastomosis 3 cm or less from the anal verge\n* Planned abdominoperineal resection (APR)\n* Planned permanent end stoma without restoration of intestinal continuity\n* Planned multivisceral resection\n* Generalized peritonitis or uncontrolled intra-abdominal sepsis\n* Pregnancy\n* Pre-existing ventral or incisional hernia at the planned extraction site\n* Planned specimen extraction through a prior laparotomy incision containing mesh\n* Fixed distal obstruction, severe pelvic stenosis, or other anatomical constraint precluding intact specimen extraction","ALL","21 Years",{"count":64,"type":65},800,"ESTIMATED","OBSERVATIONAL","Natural orifice specimen extraction (NOSE) is a minimally invasive colorectal surgical technique in which the surgical specimen is removed through a natural orifice, including transanal or transvaginal routes, thereby avoiding an abdominal extraction incision. Observational studies suggest that NOSE may reduce wound-related morbidity and improve postoperative recovery, but prospective multicenter data evaluating long-term outcomes remain limited.\n\nAP-NOSES is a prospective, multicenter observational registry evaluating clinical, patient-reported, and long-term wound outcomes following minimally invasive colorectal surgery with NOSE or transabdominal specimen extraction. The primary objective is to compare time to incisional hernia within 24 months between NOSE-eligible patients undergoing planned NOSE extraction and NOSE-eligible patients undergoing planned transabdominal extraction.\n\nSecondary objectives include evaluation of postoperative complications, extraction-related morbidity, bowel function, urinary and sexual function, oncologic outcomes, and long-term patient-reported and clinical outcomes across participating centers.\n\nThis study does not alter routine clinical care. Surgical technique, perioperative management, and follow-up are performed according to local institutional practice.",[69,70],"Colorectal Neoplasms","Incisional Hernia",[22,72,73,74,75,76,77,78,79],"NOSE surgery","Minimally invasive colorectal surgery","Incisional hernia","Laparoscopic colorectal surgery","Transanal specimen extraction","Transvaginal specimen extraction","Patient-reported outcomes","Prospective registry","2026-05-22",{"date":82,"type":83},"2026-05-29","ACTUAL",{"date":85,"type":83},"2026-05-05",{"date":87,"type":65},"2033-12-30",{"name":5,"class":6},1]