[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100573110":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":35,"responsibleParty":52,"collaborators":19,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":19,"eligibilityCriteria":59,"healthyVolunteers":56,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":19,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":19,"overallStatus":37,"whyStopped":19,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"Yunnan Cancer Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Application Value of MRI Imaging in Treatment Decision-Making for Lung Cancer","EXPERIMENTAL","A Philips 3.0T MRI scanner was used, with a dStream Torso 32-channel coil. DCE-MRI was performed using a free-breathing sequence with a flow velocity of 3.0 m\u002Fs. The image quality assessment in this study was performed by two radiologists (one with 3 years of diagnostic experience and the other with 15 years of diagnostic experience), including both subjective and objective evaluations. Then, dynamic information from the 4D FreeBreathing DCE-MRI images taken before treatment and one week after immunotherapy\u002Ftargeted therapy, along with routine clinical and pathological data, were used to construct predictive models for the efficacy of immunotherapy and targeted therapy. Finally, the MRI model was compared with the CT model, and the performance of both models was evaluated.",[13],"Diagnostic Test: Application Value of MRI Imaging in Treatment Decision-Making for Lung Cancer",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"DIAGNOSTIC_TEST","Chest MRI scans outside of the standard treatment protocol",[9],null,[21],{"name":22,"affiliation":23,"role":24},"Lianhua Ye","Ethics Committee of Yunnan Provincial Cancer Hospital","STUDY_DIRECTOR",[26,31],{"name":27,"role":28,"phone":29,"phoneExt":19,"email":30},"zhihui shi","CONTACT","15087838660","3332105746@qq.com",{"name":32,"role":28,"phone":33,"phoneExt":19,"email":34},"Zhenhui Li","13698736132","lizhenhui@kmmu.edu.cn",[36],{"facility":5,"status":37,"city":38,"state":39,"zip":19,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"RECRUITING","Kunming","Yunnan","China","CN",{"type":43,"coordinates":44},"Point",[45,46],102.71833,25.03889,{"lat":46,"lon":45},[49],{"name":50,"role":28,"phone":51,"phoneExt":19,"email":19},"Guojun Zhang","r 0871-68173640",{"type":53,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100573110","application-of-dce-mri-based-on-4d-freebreathing-in-predicting-the-efficacy-of-immune-and-targeted-therapy-in-lung-cancer-100573110",false,"NCT06742021","Application of DCE-MRI Based on 4D FreeBreathing in Predicting the Efficacy of Immune and Targeted Therapy in Lung Cancer","Inclusion Criteria:\n\n1. Tumor size greater than 2 cm\n2. Age between 18 and 75 years\n\nExclusion Criteria:\n\n1. Presence of MRI contraindications (e.g., metal implants, pacemaker implantation, etc.)\n2. Allergy to gadolinium contrast agents\n3. Lesions difficult to delineate on images due to conditions such as atelectasis or diffuse lesions","ALL","18 Years","75 Years",{"count":64,"type":65},195,"ESTIMATED","INTERVENTIONAL",[68],"NA","This study aims to address the challenge of predicting the efficacy of targeted and immunotherapy in lung cancer patients. By utilizing two DCE-MRI images-one before treatment and one after one treatment cycle-along with the patients' clinical and pathological information, we aim to achieve accurate prediction of the therapeutic efficacy of targeted and immunotherapy in lung cancer patients.",[71],"Lung Cancer","2024-12-15",{"date":74,"type":75},"2024-12-19","ACTUAL",{"date":77,"type":75},"2024-11-11",{"date":79,"type":65},"2026-07-31",{"name":5,"class":6},1]