[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100570965":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":42,"responsibleParty":59,"collaborators":26,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":26,"enrollmentInfo":70,"targetDuration":26,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":81,"overallStatus":45,"whyStopped":26,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Standard secondary prevention + digital twin","EXPERIMENTAL","Patients allocated to this arm will receive the standard secondary prevention and will also use the STRATIF-AI app, which will integrate digital twin (DT) technology to improve patient management during the secondary prevention phase and to assist patients in understanding key concepts, such as: \"Why should I care about a certain risk factor (e.g. blood pressure), and how can my lifestyle impact that risk factor? In other words, they will use the app to understand their medical situation, and to set personal goals.",[13],"Device: AI",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard secondary prevention only","ACTIVE_COMPARATOR","Patients allocated to this arm will receive only standard secondary prevention, which includes typical treatments and monitoring protocols used for patients with stroke, Moyamoya disease, and CAA.",[19],"Other: healthy dialogue",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","AI","STRATIF-AI apps will be used as an integral part of the dialogue with patients during thesecondary prevention phase",[9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"healthy dialogue","Patients allocated to arm 2 will receive only standard secondary prevention, which includes typical treatments and monitoring protocols used for patients with stroke, Moyamoya disease, and CAA",[15],[32,38],{"name":33,"role":34,"phone":35,"phoneExt":36,"email":37},"Matilde Leonardi, MD","CONTACT","+39 02 2394 2511","2521","matilde.leonardi@istituto-besta.it",{"name":39,"role":34,"phone":40,"phoneExt":36,"email":41},"Barbara Maistrello","+39 02 2394 2521","barbara.maistrello@istituto-besta.it",[43],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Fondazione IRCCS Istituto Neurologico Carlo Besta","RECRUITING","Milan","Michigan","20133","Italy","IT",{"type":52,"coordinates":53},"Point",[54,55],9.18951,45.46427,{"lat":55,"lon":54},[58],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":37},{"type":60,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100570965","application-of-digital-twins-technology-in-patients-who-had-a-stroke-with-moyamoya-disease-and-with-cerebral-amyloid-angiopathy-caa-during-the-secondary-prevention-phase-a-proof-of-concept-using-a-randomized-control-trial-clinical-study-6-stratif-ai-project-100570965",false,"NCT06714097","Application of Digital Twins' Technology in Patients Who Had a Stroke, With Moyamoya Disease and With Cerebral Amyloid Angiopathy (CAA) During the Secondary Prevention Phase: A Proof of Concept Using a Randomized Control Trial (Clinical Study 6, STRATIF-AI Project)","SMART","Inclusion Criteria:\n\n* People aged ≥ 18\n* Clinical and neuroradiological diagnosis of stroke (TAC or MR); diagnosis of CAA based on Boston 2.0 criteria; diagnosis of Moyamoya disease based on diagnostic criteria 2021.\n* MOCA total score ≥ 23\n* modified Rankin Scale (mRS) ≤ 2\n* First-time patients at the Besta Institute\n* Ability to sign informed consent\n* Possibility of performing a brain MRI\n\nExclusion Criteria:\n\n* Patients with transient neurological deficits that resolve within an hour and normal brain imaging\n* Patient under legal protection or deprived of liberty by judicial or administrative decision\n* Patient whose follow-up will be impossible\n* Contraindication to magnetic resonance imaging and\u002For Digital subtraction angiography (DSA)\n* Pregnant patients\n* Known or suspected drug or alcohol abuse","ALL","18 Years",{"count":71,"type":72},20,"ESTIMATED","INTERVENTIONAL",[75],"NA","The goal of this clinical trial is to obtain initial feedback on the implementation of the STRATIF-AI platform and digital twin in the secondary prevention phase in patients with stroke, Moyamoya disease and Cerebral amyloid angiopathy, including adults of both sexes.\n\nThe main questions it aims to answer is: how is the patients' experience regarding the use of the STRATIF-AI platform? Researchers will compare Arm 1, who use the STRATIF-AI app in addition to standard secondary prevention, against Arm 2, who receive standard secondary prevention only, to collect feedback regarding the platform usability.\n\nParticipants in the Arm 1 will:\n\n* Complete cognitive and psychological assessments at the time of the first visit and after six months\n* Follow the indications received from the clinician for standard secondary prevention\n* Use the STRATIF-AI app daily for health management\n* Optionally, purchase wearable devices that connect to the app.\n* Participate in interviews at the six-month mark to share their experiences with the app.\n\nPatients in the Arm 2 will:\n\n* Complete cognitive and psychological assessments at the time of the first visit and after six months\n* Follow the indications received from the clinician for standard secondary prevention",[78,79,80],"Stroke","Moyamoya Disease","Cerebral Amyloid Angiopathy",[82,83,84,79,80],"stroke","secondary prevention","digital twin","2026-03-25",{"date":87,"type":88},"2026-03-30","ACTUAL",{"date":90,"type":72},"2026-04",{"date":92,"type":72},"2027-04",{"name":5,"class":6},1]