[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100557740":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":28,"centralContacts":32,"locations":38,"responsibleParty":54,"collaborators":10,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":10,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":10,"maxAge":10,"enrollmentInfo":64,"targetDuration":10,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":73,"whyStopped":10,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Shenzhen Third People's Hospital","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"NAS group",null,"In this group, the investigators will detect the number of pathogen in alveolar lavage fluid, blood and peritoneal drainage by using NAS.",[13],"Diagnostic Test: NAS, NGS and Laboratory tests",{"label":15,"type":10,"description":16,"interventionNames":17},"NGS group","In this group, the investigators will detect the number of pathogen in alveolar lavage fluid, blood and peritoneal drainage by using NGS.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Lab Tests group","In this group, the investigators will detect the number of pathogen in alveolar lavage fluid, blood and peritoneal drainage by using laboratory tests.",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":10},"DIAGNOSTIC_TEST","NAS, NGS and Laboratory tests","Using three diffrent detection methods and comparing their efficiency",[19,9,15],[29],{"name":30,"affiliation":5,"role":31},"Lin Zhong, Dr","PRINCIPAL_INVESTIGATOR",[33],{"name":34,"role":35,"phone":36,"phoneExt":10,"email":37},"pusen Wang, Dr","CONTACT","18621006138","pusenwang@sjtu.edu.cn",[39],{"facility":5,"status":10,"city":40,"state":41,"zip":10,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Shenzhen","Guangdong","China","CN",{"type":45,"coordinates":46},"Point",[47,48],114.0683,22.54554,{"lat":48,"lon":47},[51],{"name":30,"role":35,"phone":52,"phoneExt":10,"email":53},"13917603139","zhonglin1@medmail.com.cn",{"type":55,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100557740","application-of-nanopore-adaptive-sequencing-100557740",false,"NCT06542042","Application of Nanopore Adaptive Sequencing","Application of Oxford Nanopore Adaptive Sequencing Method in Infection Post Liver Transplantation","Inclusion Criteria:\n\n* Accept liver transplantation\n* Signing informed consent voluntarily\n* Possessing ability to comprehend material information\n* Participating this study voluntarily\n\nExclusion Criteria:\n\n* Participated another study\n* Graft loss\n* Have undergone a multi-organ transplantion or have had a previous organ transplantation\n* Patient died","ALL",{"count":65,"type":66},100,"ESTIMATED","OBSERVATIONAL","Infection post liver transplantation is an important factor in the death in patients. The traditional method of diagnosing infection post liver transplantation is laboratory tests. But the sensitivity and specificity of blood tests is poor. Next-generation sequencing (NGS) has greater detection rate for mycobacterium tuberculosis, anaerobes and fungi and greater sensitivity compare with blood tests. However use of NGS is limited because of the short read-length. Oxford nanopore adaptive sequencing (NAS) method is the Third Revolution in Sequencing Technology. For each 1 Gbp of data, NAS sequencing detected 45 times more microbiome sequences than Nanopore standard sequencing and 2.5 times more than Illumina sequencing. The purpose of this study is to compare NAS with NGS and laboratory tests for the diagnostic rate of infection post liver transplantation.",[70],"Liver Transplant Infection",[72],"Oxford nanopore adaptive sequencing method","NOT_YET_RECRUITING","2024-08-06",{"date":76,"type":77},"2024-08-07","ACTUAL",{"date":79,"type":66},"2024-10-01",{"date":81,"type":66},"2026-10-30",{"name":5,"class":6},1]