[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100593158":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":45,"responsibleParty":65,"collaborators":68,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":75,"acronym":26,"eligibilityCriteria":76,"healthyVolunteers":73,"sex":77,"minAge":78,"maxAge":26,"enrollmentInfo":79,"targetDuration":26,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":48,"whyStopped":26,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Harbin Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"remimazolam plus esketamine group","EXPERIMENTAL","Esketamine combined with remimazolamwas used for anesthesia.",[13],"Combination Product: remimazolam-esketamine",{"label":15,"type":16,"description":17,"interventionNames":18},"remimazolam plus remifentanil group","ACTIVE_COMPARATOR","Remifentanil combined with remimazolam was used for anesthesia.",[19],"Combination Product: remimazolam-remifentanil",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"COMBINATION_PRODUCT","remimazolam-remifentanil","For elderly patients scheduled for elective painless gastro-intestinal endoscopy, remimazolam 0.2mg\u002Fkg and remifentanil 0.2ug\u002Fkg are used for anesthesia induction. During the operation, the doses are adjusted according to the depth of sedation of the patients.",[15],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"remimazolam-esketamine","For elderly patients scheduled for painless gastroenterological endoscopy, remimazolam 0.2mg\u002Fkg and esketamine 0.15mg\u002Fkg are used for anesthesia induction. During the operation, the dosage is adjusted according to the patient's level of sedation.",[9],[32],{"name":33,"affiliation":26,"role":34},"SHI Jinghui SHI","STUDY_DIRECTOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"LIU Shujie LIU","CONTACT","+86 138 4508 0390","shujieliu312@163.com",{"name":42,"role":38,"phone":43,"phoneExt":26,"email":44},"SHI Xiaoqian SHI","+86 188 3424 7923","shixiaoqian005@163.com",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"The First Affiliated Hospital of Harbin Medical University","RECRUITING","Harbin","Heilongjiang","150001","China","CN",{"type":55,"coordinates":56},"Point",[57,58],126.65,45.75,{"lat":58,"lon":57},[61,62,63],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},{"name":42,"role":38,"phone":43,"phoneExt":26,"email":44},{"name":42,"role":64,"phone":26,"phoneExt":26,"email":26},"PRINCIPAL_INVESTIGATOR",{"type":64,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Shi xiaoqian","Graduate student",[69],{"name":70,"class":6},"First Affiliated Hospital of Harbin Medical University","100593158","application-of-remimazolam-combined-with-esketamine-in-painless-gastroscopy-and-colonoscopy-in-elderly-patients-100593158",false,"NCT07002801","Application of Remimazolam Combined With Esketamine in Painless Gastroscopy and Colonoscopy in Elderly Patients","Inclusion Criteria:\n\n1. Patients undergoing painless gastroenteroscopy in outpatient clinics;\n2. aged 65 years and above;\n3. American Society of Anesthesiologists (ASA) grades I - III.\n\nExclusion Criteria:\n\n1. Patients with abnormal liver or kidney function;\n2. known respiratory or endocrine diseases;\n3. Patients with uncontrolled hypertension and NYHA classification Ⅲ-Ⅳ;\n4. Taking monoamine oxidase inhibitors, sedatives, analgesics, hypnotics, antipsychotics, antiemetics or antidepressants;\n5. Addiction to tobacco and alcohol;\n6. Patients allergic to the investigational drug;\n7. expected difficult airway;\n8. Body mass index (BMI) \\>35kg\u002Fm\\^2;\n9. Have participated in other clinical trials within the past three months;\n10. Patients with psychosocial illness or cognitive dysfunction and inability to cooperate or communicate.","ALL","65 Years",{"count":80,"type":81},280,"ESTIMATED","INTERVENTIONAL",[84],"NA","The objective of this clinical trial is to assess the feasibility of the remimazolam combined with esketamine OFA (opioid-free anesthesia) protocol for painless gastroscopy and colonoscopy in elderly patients and to determine if it is non-inferior to the traditional OA (opioid-containing anesthesia) protocol. The main questions it aims to answer are:\n\n* Is the remimazolam combined with esketamine protocol feasible for painless gastroscopy and colonoscopy in elderly patients?\n* Is the OFA protocol superior to the OA protocol?\n\nParticipants will:\n\n* During anesthesia induction, the experimental group will receive remimazolam combined with esketamine for anesthesia, while the control group will receive remimazolam combined with remifentanil.\n* Record respiratory and circulatory indicators and adverse reaction times.",[87],"Gastrointestinal Disease",[89,90,91,92],"remimazolam","esketamine","painless gastroscopy and colonoscopy","success rate of calming down","2025-05-26",{"date":95,"type":96},"2025-06-04","ACTUAL",{"date":98,"type":96},"2025-03-14",{"date":100,"type":81},"2028-01",{"name":5,"class":6},1]