[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100551360":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":12,"responsibleParty":36,"collaborators":12,"id":40,"slug":41,"hasResults":42,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":12,"eligibilityCriteria":46,"healthyVolunteers":42,"sex":47,"minAge":12,"maxAge":48,"enrollmentInfo":49,"targetDuration":12,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":63,"whyStopped":12,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":12},{"fullName":5,"class":6},"The First Affiliated Hospital of Air Force Medicial University","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Routine Care group","NO_INTERVENTION","After induction of general intravenous anesthesia, 100% oxygen mask ventilation was used for pre-oxygenation, wait 2-3 min to vecuronium take effect and reaching end-expiratory oxygen saturation \\> 90%, the Optiflow THRIVETM system nasal plug is placed in the proper position, but without oxygen supply, and the tracheal intubation is started.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"THRIVE group","EXPERIMENTAL","After induction of general intravenous anesthesia, 100% oxygen mask ventilation was used for pre-oxygenation, wait 2-3 min to vecuronium take effect and reaching end-expiratory oxygen saturation \\> 90%, Immediately after ceasing assisted ventilation, the age-appropriate nasal prongs were applied and weight-specific high flow rates delivered using the(Transnasal humidified rapid-insufflation ventilatory exchange, THRIVE) Optiflow THRIVE TM system. The flow rates applied were as follows: 0-15 kg, 2 litres kg-1 min-1；15-30 kg, 35 litres min-1; 30-50 kg, 40 litres min-1; and\\>50 kg, 50 litres min-1,and the tracheal intubation is started",[18],"Device: Transnasal humidified rapid-insufflation ventilatory exchange (THRIVE)",[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":12},"DEVICE","Transnasal humidified rapid-insufflation ventilatory exchange (THRIVE)","Immediately after ceasing assisted ventilation, before intubation the age-appropriate nasal prongs were applied and weight-specific high flow rates delivered using the Optiflow THRIVETM system. The flow rates applied were as follows: 0-15 kg, 2 litres kg-1 min-1；15-30 kg, 35 litres min-1; 30-50 kg, 40 litres min-1; and\\>50 kg, 50 litres min-1.",[14],[26],{"name":27,"affiliation":28,"role":29},"shuxiu wang, PH.D","The Xijing Hospital of Air Force Military Medical University","PRINCIPAL_INVESTIGATOR",[31],{"name":32,"role":33,"phone":34,"phoneExt":12,"email":35},"dandan cheng, PH.D","CONTACT","+86 029 84775343","wangshuxiuzi@163.com",{"type":37,"investigatorFullName":38,"investigatorTitle":39,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"SPONSOR_INVESTIGATOR","Shuxiu Wang","Principal Investigator","100551360","application-of-thrive-in-burn-children-with-suspected-difficult-airway-100551360",false,"NCT06459076","Application of THRIVE in Burn Children With Suspected Difficult Airway","Application of Transnasal Humidified Rapid-insufflation Ventilatory Exchange (THRIVE) in Burn Children With Suspected Difficult Airway：A Single-center, Randomized Controlled Study","Inclusion Criteria:\n\n* \\\u003C 18 years\n* ASA Grade I \\~ III\n* Children with head, face and neck scald or burn or flame or electrical c hemical or other\n\nExclusion Criteria:\n\n* Refusal or failure to sign an informed consent\n* Proposed to transnasal intubation\n* Fracture of the nasal bone, nasal bleeding, nasal deformity or obstruction\n* Tracheotomy status or severe head, face and neck burn or burn scar (difficult airway)\n* Unsuitable for rapid sequence induction\n* Basicranial fracture\n* Cyanotic congenital heart defect\n* At risk of malignant hyperthermia\n* And is participating in other clinical studies","ALL","18 Years",{"count":50,"type":51},120,"ESTIMATED","INTERVENTIONAL",[54],"NA","In order to improve intubation conditions in burn children, our aim is to investigate the efficacy of transnasal humidified rapid-insufflation ventilatory exchange technique（THRIVE) in children aged between 0 and 18 years who with head, face, and neck injuries by fire, scalding, chemical, electric,explosions, and others. We hypothesise that THRIVE increases first attempt success without hypoxemia in intubation of children and compared with routine practice.\n\nDoes the THRIVE can prolong apnoea time and delay the onset of desaturation to increase the success rate of the first tracheal intubation without desaturation?\n\nResearchers will compare THRIVE group with Routine care group to see successful intubation on the first attempt without desaturation.\n\nParticipants will received intravenous anesthesia induction, followed by 2-3 minutes preoxygenation, before intubation, the mask was removed from the children's face and a THRIVE nasal plug was placed. During intubation, the Routine care group had no oxygen supply,and the THRIVE group will be maintained throughout the apnoeic period with selected flow rates during intubation attempts.",[57],"Intubation; Difficult or Failed",[59,60,61,62],"THRIVE","burn children","airway","intubation","NOT_YET_RECRUITING","2024-07-02",{"date":66,"type":67},"2024-07-05","ACTUAL",{"date":69,"type":51},"2024-07-01",{"date":71,"type":51},"2026-05",{"name":38,"class":6}]