[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628466":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":37,"locations":46,"responsibleParty":83,"collaborators":11,"id":85,"slug":86,"hasResults":87,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":11,"eligibilityCriteria":91,"healthyVolunteers":87,"sex":92,"minAge":93,"maxAge":11,"enrollmentInfo":94,"targetDuration":11,"studyType":97,"phases":98,"briefSummary":100,"conditions":101,"keywords":104,"overallStatus":49,"whyStopped":11,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":121},{"fullName":5,"class":6},"Military Institute od Medicine National Research Institute","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Glaucoma + Cataract Group","EXPERIMENTAL",null,[13],"Procedure: Phacoemulsification With Intraocular Lens Implantation and Deep Sclerectomy",{"label":15,"type":16,"description":11,"interventionNames":17},"Cataract Control Group","ACTIVE_COMPARATOR",[18],"Procedure: Phacoemulsification With Intraocular Lens Implantation",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"PROCEDURE","Phacoemulsification With Intraocular Lens Implantation and Deep Sclerectomy","Standard-of-care combined cataract surgery (phacoemulsification with intraocular lens implantation) performed together with deep sclerectomy for glaucoma management. Intraoperative collection of aqueous humor and routinely removed ocular tissues (such as sclera and anterior lens capsule) is performed for research analyses.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Phacoemulsification With Intraocular Lens Implantation","Standard-of-care cataract surgery (phacoemulsification with intraocular lens implantation). Intraoperative collection of aqueous humor and routinely removed ocular tissue (anterior lens capsule) is performed for research analyses.",[15],[30,34],{"name":31,"affiliation":32,"role":33},"Marek Rękas, MD, PhD","Military Institute of Medicine National Research Institute","PRINCIPAL_INVESTIGATOR",{"name":35,"affiliation":36,"role":33},"Ewa Bulska, PhD","University of Warsaw",[38,42],{"name":31,"role":39,"phone":40,"phoneExt":11,"email":41},"CONTACT","0048665 707 626","mrekas@wim.mil.pl",{"name":43,"role":39,"phone":44,"phoneExt":11,"email":45},"Wojciech Mazurek, MD","0048261 816 575","wmazurek@wim.mil.pl",[47,69],{"facility":48,"status":49,"city":50,"state":11,"zip":11,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Military Institute of Medicine - National Research Institute","RECRUITING","Warsaw","Poland","PL",{"type":54,"coordinates":55},"Point",[56,57],21.01178,52.22977,{"lat":57,"lon":56},[60,61,63,65,67],{"name":31,"role":39,"phone":40,"phoneExt":11,"email":41},{"name":43,"role":62,"phone":11,"phoneExt":11,"email":11},"SUB_INVESTIGATOR",{"name":64,"role":62,"phone":11,"phoneExt":11,"email":11},"Katarzyna Lewczuk, MD, PhD",{"name":66,"role":62,"phone":11,"phoneExt":11,"email":11},"Joanna Jabłońska, MD, PhD",{"name":68,"role":62,"phone":11,"phoneExt":11,"email":11},"Barbara Rękas-Mazurek, MD",{"facility":36,"status":49,"city":50,"state":11,"zip":11,"country":51,"countryCode":52,"cosmosGeoPoint":70,"geoPoint":72,"contacts":73},{"type":54,"coordinates":71},[56,57],{"lat":57,"lon":56},[74,77,79,81],{"name":35,"role":39,"phone":75,"phoneExt":11,"email":76},"0048604 119 870","ebulska@chem.uw.edu.pl",{"name":78,"role":62,"phone":11,"phoneExt":11,"email":11},"Anna Ruszczyńska, PhD",{"name":80,"role":62,"phone":11,"phoneExt":11,"email":11},"Andrzej Gawor, PhD",{"name":82,"role":62,"phone":11,"phoneExt":11,"email":11},"Olha Dushna, PhD",{"type":84,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100628466","aqueous-humor-and-ocular-tissue-analysis-in-glaucoma-and-cataract-100628466",false,"NCT07462000","Aqueous Humor and Ocular Tissue Analysis in Glaucoma and Cataract","Integrated Chemical and Proteomic Analysis of Aqueous Humor and Ocular Tissues in Glaucoma and Cataract Patients","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Scheduled for cataract surgery (phacoemulsification with intraocular lens implantation).\n* Ability to provide written informed consent.\n* For glaucoma arm: diagnosis of primary open-angle glaucoma (POAG) with coexisting cataract, and planned combined cataract surgery with glaucoma procedure.\n* For control arm: cataract without glaucoma and without other significant ocular pathology.\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years.\n* Pregnancy or breastfeeding.\n* Advanced visual impairment in the study eye (visual aquity worse than counting fingers).\n* Any glaucoma type other than primary open-angle glaucoma (e.g., angle-closure, secondary, neovascular glaucoma).\n* History of intraocular surgery in the study eye (including glaucoma surgery), vitreoretinal surgery, corneal transplantation, or refractive surgery.\n* Active or previous uveitis.\n* Other significant chronic ocular disease in the study eye (other than cataract and POAG in the glaucoma arm).\n* Inability to comply with study procedures or follow-up visits.","ALL","18 Years",{"count":95,"type":96},40,"ESTIMATED","INTERVENTIONAL",[99],"NA","This observational study will compare proteomic and elemental profiles of aqueous humor and ocular tissues in patients with primary open-angle glaucoma (POAG) and cataract versus cataract controls without glaucoma. Samples collected during standard surgery will be analyzed using LC-MS\u002FMS and ICP-MS. The goal is to identify glaucoma-associated molecular patterns with potential diagnostic or prognostic relevance.",[102,103],"Primary Open-Angle Glaucoma (POAG)","Cataract",[105,106,103,107,108,109,110,111],"POAG","Glaucoma","Primary Open-Angle Glaucoma","Proteomics","Aqueous Humor","LC-MS\u002FMS","Deep Sclerectomy","2026-03-06",{"date":114,"type":115},"2026-03-10","ACTUAL",{"date":117,"type":115},"2026-01-21",{"date":119,"type":96},"2027-11-30",{"name":5,"class":6},2]