[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625329":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":17,"locations":27,"responsibleParty":146,"collaborators":150,"id":169,"slug":170,"hasResults":171,"nctId":172,"briefTitle":173,"officialTitle":174,"acronym":175,"eligibilityCriteria":176,"healthyVolunteers":171,"sex":177,"minAge":178,"maxAge":179,"enrollmentInfo":180,"targetDuration":10,"studyType":183,"phases":10,"briefSummary":184,"conditions":185,"keywords":188,"overallStatus":193,"whyStopped":10,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":195,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":203},{"fullName":5,"class":6},"Vastra Gotaland Region","OTHER_GOV",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Children with non-progressive congenital ataxia (NPCA)",null,"Eligible population: male and female children, aged 5 to 8 years at time of clinical examination, with a confirmed diagnosis of non-progressive congenital ataxia (NPCA)\u002FAtaxic cerebral palsy, according to SCPE criteria. Participants are recruited from eight European countries (France, Belgium, Denmark, Germany, Greece, Norway and Sweden) through university and regional hospitals, outpatient neurology\u002Frehabilitation clinics and CP registries.\n\nStandardized data collection will include comprehensive clinical evaluation, brain MRI (review of images from neonatal or post neonatal periods), genetic analyses, assessment of children's quality of life and parental psychological health.\n\nGenetics: Genomic and transcriptomic analyses Advanced genomic analyses (exome, genome, RNA-seq) performed on existing or newly collected blood samples from children with NPCA\u002Fataxic CP to identify disease-associated variants. This includes re-analysis of existing sequencing data and\u002For new datasets.",[13],{"name":14,"affiliation":15,"role":16},"Catherine Arnaud, MD PhD","University Hospital of Toulouse","STUDY_DIRECTOR",[18,23],{"name":19,"role":20,"phone":21,"phoneExt":10,"email":22},"Kate Himmelmann, MD PhD","CONTACT","+46 702225589, +46 722039472","kate.himmelmann@vgregion.se",{"name":24,"role":20,"phone":25,"phoneExt":10,"email":26},"Catherine Arnaud","+33 05 67 77 12 85","catherine.arnaud@utoulouse.fr",[28,46,60,76,94,111,128],{"facility":29,"status":10,"city":30,"state":10,"zip":10,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"KU Leuven","Leuven","Belgium","BE",{"type":34,"coordinates":35},"Point",[36,37],4.70093,50.87959,{"lat":37,"lon":36},[40,43],{"name":41,"role":20,"phone":10,"phoneExt":10,"email":42},"Els Ortibus, MD PhD","els.ortibus@uzleuven.be",{"name":44,"role":20,"phone":10,"phoneExt":10,"email":45},"Joke Opdenacker","joke opdenacker \u003Cjoke.opdenacker@kuleuven.be>",{"facility":47,"status":10,"city":48,"state":10,"zip":10,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":55,"contacts":56},"Aarhus University Hospital","Aarhus","Denmark","DK",{"type":34,"coordinates":52},[53,54],10.21076,56.15674,{"lat":54,"lon":53},[57],{"name":58,"role":20,"phone":10,"phoneExt":10,"email":59},"Gija Rackauskaite, MD PhD","Gija Rackauskaite \u003Cgija.rackauskaite@auh.rm.dk>",{"facility":61,"status":10,"city":62,"state":10,"zip":10,"country":63,"countryCode":64,"cosmosGeoPoint":65,"geoPoint":69,"contacts":70},"Toulouse University Hospital","Toulouse","France","FR",{"type":34,"coordinates":66},[67,68],1.44367,43.60426,{"lat":68,"lon":67},[71,75],{"name":72,"role":20,"phone":73,"phoneExt":10,"email":74},"Caroline Karsenty","+33","karsenty.c@chu-toulouse.fr",{"name":24,"role":20,"phone":25,"phoneExt":10,"email":26},{"facility":77,"status":10,"city":78,"state":10,"zip":10,"country":79,"countryCode":80,"cosmosGeoPoint":81,"geoPoint":85,"contacts":86},"University Hospital Tübingen","Tübingen","Germany","DE",{"type":34,"coordinates":82},[83,84],9.05222,48.52266,{"lat":84,"lon":83},[87,91],{"name":88,"role":20,"phone":89,"phoneExt":10,"email":90},"Veronka Horber, MD","+49 17209276720","veronka.horber@med.uni-tuebingen.de",{"name":92,"role":20,"phone":10,"phoneExt":10,"email":93},"Janine Magg","janine.magg@med.uni-tuebingen",{"facility":95,"status":10,"city":96,"state":10,"zip":10,"country":97,"countryCode":98,"cosmosGeoPoint":99,"geoPoint":103,"contacts":104},"IASO Children's Hospital","Athens","Greece","GR",{"type":34,"coordinates":100},[101,102],23.72784,37.98376,{"lat":102,"lon":101},[105,108],{"name":106,"role":20,"phone":10,"phoneExt":10,"email":107},"Antigone Papavasiliou, MD PhD","theon@otenet.gr",{"name":109,"role":20,"phone":10,"phoneExt":10,"email":110},"Nikoletta Smyrni, MD","nicolsmy7@gmail.com",{"facility":112,"status":10,"city":113,"state":10,"zip":10,"country":114,"countryCode":115,"cosmosGeoPoint":116,"geoPoint":120,"contacts":121},"Vestfold Hospital Trust","Tønsberg","Norway","NO",{"type":34,"coordinates":117},[118,119],10.40762,59.26754,{"lat":119,"lon":118},[122,125],{"name":123,"role":20,"phone":10,"phoneExt":10,"email":124},"Guro L Andersen, MD PhD","Guro.Andersen@siv.no",{"name":126,"role":20,"phone":10,"phoneExt":10,"email":127},"Sandra Julsen Hollung, PhD","sandra.julsen.hollung@siv.no",{"facility":129,"status":10,"city":130,"state":10,"zip":131,"country":132,"countryCode":133,"cosmosGeoPoint":134,"geoPoint":138,"contacts":139},"Queen Silvia Children's Hospital at Sahlgrenska University Hospital","Gothenburg","416 50","Sweden","SE",{"type":34,"coordinates":135},[136,137],11.96679,57.70716,{"lat":137,"lon":136},[140,142],{"name":19,"role":20,"phone":141,"phoneExt":10,"email":22},"+31 702 225589, +31 722039472",{"name":143,"role":20,"phone":144,"phoneExt":10,"email":145},"Magnus Påhlman, MD PhD","+31 703 91 35 61","magnus.pahlman@vgregion.se",{"type":147,"investigatorFullName":148,"investigatorTitle":149,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Kate Himmelmann","Coordinating investigator",[151,154,156,158,161,162,163,165,167],{"name":152,"class":153},"University Hospital, Toulouse","OTHER",{"name":155,"class":153},"Universität Tübingen",{"name":157,"class":153},"University Hospital Tuebingen",{"name":159,"class":160},"Sykehuset i Vestfold Hospital Trust","UNKNOWN",{"name":47,"class":153},{"name":29,"class":153},{"name":164,"class":153},"Sahlgrenska University Hospital",{"name":166,"class":153},"Göteborg University",{"name":168,"class":160},"IASO Children's Hospital, Maroussi, Athens, Greece","100625329","artemis---the-artemis-cohort-100625329",false,"NCT07421219","ARTEMIS - The ARTEMIS Cohort","Non-progressive Congenital Ataxia - Advancing Diagnosis to Enhance Chances for Targeted Therapy","ARTEMIS","Inclusion Criteria: • male or female children\n\n* confirmed diagnosis of NPCA\u002FAtaxic CP (SCPE definition)\n* aged ≥ 5 years and ≤ 8 years at time of data collection\n* written informed consent of at least one parent or legal representative in accordance to country regulations, and verbal assent of the child when possible\n\nExclusion Criteria: Children with all other diagnoses of movement disorders or other CP subtypes\n\n\\-","ALL","5 Years","8 Years",{"count":181,"type":182},50,"ESTIMATED","OBSERVATIONAL","This multinational European observational clinical study focuses on non-progressive congenital ataxia (NPCA), a very rare early-onset neurological condition also within the cerebral palsy (CP) concept as ataxic CP. The study aims to improve the diagnosis and care of affected children through a comprehensive approach that integrates detailed clinical assessments, brain imaging analyses, and advanced genetic testing. By identifying developmental trajectories, specific impairment profiles, brain MRI patterns, and genetic variants, the researchers aim to elucidate underlying mechanisms, origins and clinical heterogeneity of NPCA. The study also assesses the broader impact of the condition on the quality of life of affected children and the associated burden on their families. Preliminary data found a high prevalence of cognitive and neuropsychiatric impairments, and a frequent lack of identifiable brain lesions on MRI, raising the hypothesis of a strong genetic contribution.",[186,187],"Non-progressive Congenital Ataxia","Ataxic Cerebral Palsy",[186,187,189,190,191,192],"Genetic etiology","Neuroimaging","Neurodevelopmental disorders","Quality of Life","NOT_YET_RECRUITING","2026-02-11",{"date":196,"type":197},"2026-02-19","ACTUAL",{"date":199,"type":182},"2026-04",{"date":201,"type":182},"2027-12-31",{"name":5,"class":6},7]