[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100618290":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":30,"locations":39,"responsibleParty":360,"collaborators":363,"id":395,"slug":396,"hasResults":397,"nctId":398,"briefTitle":399,"officialTitle":400,"acronym":401,"eligibilityCriteria":402,"healthyVolunteers":397,"sex":403,"minAge":404,"maxAge":25,"enrollmentInfo":405,"targetDuration":25,"studyType":408,"phases":409,"briefSummary":411,"conditions":412,"keywords":416,"overallStatus":42,"whyStopped":25,"lastUpdateSubmitDate":420,"lastUpdatePostDateStruct":421,"startDateStruct":424,"completionDateStruct":426,"leadSponsor":428,"locationsCount":429},{"fullName":5,"class":6},"Samsung Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"MPFFR-guided PCI group","EXPERIMENTAL","In patients randomized to artificial intelligence-driven angiography-based fractional flow reserve (MPFFR)-guided PCI group, MPFFR analysis will be performed using MPFFR-1000 version 2.1.0 (Medipixel Inc., Seoul, Korea). Manual correction can be applied when necessary, however, it will be strongly discouraged by the study protocols. Treatment decisions will be made based on site-measured MPFFR value.\n\nFunctionally significant stenosis will be defined as MPFFR≤0.80. For lesions with MPFFR≤0.80, PCI will be recommended under current guidelines, however, final decision regarding PCI will be at the discretion of operators. In the MPFFR-guided PCI group, on-site MPFFR value will be used in decision making of revascularization. If PCI is not performed for lesions with MPFFR≤0.80, the specific reasons will be collected in electronic case report form. For lesions with MPFFR\\>0.80, PCI will be deferred.",[13],"Diagnostic Test: MPFFR or Invasive FFR",{"label":15,"type":16,"description":17,"interventionNames":18},"Invasive FFR-guided PCI group","ACTIVE_COMPARATOR","All invasive FFR measurements will be performed after diagnostic coronary angiography according to a standardized protocol as previously described. A pressure-temperature sensor guide wire (Abbott Vascular, Santa Clara, CA, USA) is positioned at the distal segment of the target lesion. To induce maximal hyperemia state, intravenous infusion of adenosine (140μg\u002Fkg\u002Fmin through a peripheral vein) or intracoronary injection of nicorandil (2mg) will be used. In the presence of drift greater than 0.03 FFR unit, pressure wire will be re-equalized and FFR will be measured again.\n\nFunctionally significant stenosis will be defined as FFR≤0.80. For lesions with FFR≤0.80, PCI will be recommended under current guidelines, however, final decision regarding PCI will be at the discretion of operators. If PCI is not performed for lesions with FFR≤0.80, the specific reasons will be collected in electronic case report form. For lesions with FFR\\>0.80, PCI will be deferred.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DIAGNOSTIC_TEST","MPFFR or Invasive FFR","Functionally significant stenosis will be defined as MPFFR≤0.80 or FFR≤0.80. For lesions with MPFFR≤0.80 or FFR≤0.80, PCI will be recommended under current guidelines, however, final decision regarding PCI will be at the discretion of operators. In the MPFFR-guided PCI group, on-site MPFFR value will be used in decision making of revascularization. If PCI is not performed for lesions with MPFFR≤0.80 or FFR≤0.80, the specific reasons will be collected in electronic case report form. For lesions with MPFFR\\>0.80 or FFR\\>0.80, PCI will be deferred.",[15,9],null,[27],{"name":28,"affiliation":5,"role":29},"Joo Myung Lee, MD, MPH, PhD","PRINCIPAL_INVESTIGATOR",[31,35],{"name":28,"role":32,"phone":33,"phoneExt":25,"email":34},"CONTACT","0234102575","drone80@hanmail.net",{"name":36,"role":32,"phone":37,"phoneExt":25,"email":38},"Seung Hun Lee, MD, PhD","821064137449","lsh8602@naver.com",[40,57,70,83,93,106,119,137,154,167,180,195,210,220,237,250,270,284,294,304,317,332,345],{"facility":41,"status":42,"city":43,"state":44,"zip":25,"country":45,"countryCode":25,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Korea University Anam Hospital","RECRUITING","Seoul","Select State","South Korea",{"type":47,"coordinates":48},"Point",[49,50],126.9784,37.566,{"lat":50,"lon":49},[53,56],{"name":54,"role":32,"phone":25,"phoneExt":25,"email":55},"Jung-Joon Cha, MD, PhD","joonletter@hanmail.net",{"name":54,"role":29,"phone":25,"phoneExt":25,"email":25},{"facility":58,"status":42,"city":59,"state":25,"zip":25,"country":45,"countryCode":25,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"Inje University Haeundae Paik Hospital","Busan",{"type":47,"coordinates":61},[62,63],129.03004,35.10168,{"lat":63,"lon":62},[66,69],{"name":67,"role":32,"phone":25,"phoneExt":25,"email":68},"Dong Ki Kim, MD, PhD","imnpymd@gmail.com",{"name":67,"role":29,"phone":25,"phoneExt":25,"email":25},{"facility":71,"status":42,"city":72,"state":25,"zip":25,"country":45,"countryCode":25,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"Changwon Fatima Hospital","Changwon",{"type":47,"coordinates":74},[75,76],128.68111,35.22806,{"lat":76,"lon":75},[79,82],{"name":80,"role":32,"phone":25,"phoneExt":25,"email":81},"Jae Kwang Lee, MD, PhD","2707wc@hanmail.net",{"name":80,"role":29,"phone":25,"phoneExt":25,"email":25},{"facility":84,"status":42,"city":72,"state":25,"zip":25,"country":45,"countryCode":25,"cosmosGeoPoint":85,"geoPoint":87,"contacts":88},"Gyeongsang National University Changwon Hospital",{"type":47,"coordinates":86},[75,76],{"lat":76,"lon":75},[89,92],{"name":90,"role":32,"phone":25,"phoneExt":25,"email":91},"Jong Hwa Ahn, MD, PhD","jonghwaahn@naver.com",{"name":90,"role":29,"phone":25,"phoneExt":25,"email":25},{"facility":94,"status":42,"city":95,"state":25,"zip":25,"country":45,"countryCode":25,"cosmosGeoPoint":96,"geoPoint":100,"contacts":101},"Keimyung University Dongsan Hospital","Daegu",{"type":47,"coordinates":97},[98,99],128.59111,35.87028,{"lat":99,"lon":98},[102,105],{"name":103,"role":32,"phone":25,"phoneExt":25,"email":104},"Hyuck-Jun Yoon, MD, PhD","hippsons@gmail.com",{"name":103,"role":29,"phone":25,"phoneExt":25,"email":25},{"facility":107,"status":42,"city":95,"state":25,"zip":25,"country":45,"countryCode":25,"cosmosGeoPoint":108,"geoPoint":110,"contacts":111},"Kyungpook National University Hospital",{"type":47,"coordinates":109},[98,99],{"lat":99,"lon":98},[112,115,116],{"name":113,"role":32,"phone":25,"phoneExt":25,"email":114},"Namkyun Kim, MD, PhD","namkyun.kim@knu.ac.kr",{"name":113,"role":29,"phone":25,"phoneExt":25,"email":25},{"name":117,"role":118,"phone":25,"phoneExt":25,"email":25},"Jang Hoon Lee, MD, PhD","SUB_INVESTIGATOR",{"facility":120,"status":42,"city":121,"state":25,"zip":25,"country":45,"countryCode":25,"cosmosGeoPoint":122,"geoPoint":126,"contacts":127},"Chonnam National University Hospital, Chonnam National University Medical School","Gwangju",{"type":47,"coordinates":123},[124,125],126.91556,35.15472,{"lat":125,"lon":124},[128,131,133,134,135],{"name":129,"role":32,"phone":25,"phoneExt":25,"email":130},"Young Joon Hong, MD, PhD","hyj200@hanmail.net",{"name":36,"role":32,"phone":132,"phoneExt":25,"email":38},"82-10-6413-7449",{"name":129,"role":29,"phone":25,"phoneExt":25,"email":25},{"name":36,"role":118,"phone":25,"phoneExt":25,"email":25},{"name":136,"role":118,"phone":25,"phoneExt":25,"email":25},"Joon Ho Ahn, MD, PhD",{"facility":138,"status":42,"city":139,"state":25,"zip":25,"country":45,"countryCode":25,"cosmosGeoPoint":140,"geoPoint":144,"contacts":145},"Chung-Ang University Gwangmyeong Hospital","Gwangmyeong",{"type":47,"coordinates":141},[142,143],126.86639,37.47722,{"lat":143,"lon":142},[146,149,150,152],{"name":147,"role":32,"phone":25,"phoneExt":25,"email":148},"Sang Yeub Lee, MD, PhD","louisahj@gmail.com",{"name":147,"role":29,"phone":25,"phoneExt":25,"email":25},{"name":151,"role":118,"phone":25,"phoneExt":25,"email":25},"Jinhwan Jo, MD, PhD",{"name":153,"role":118,"phone":25,"phoneExt":25,"email":25},"Jun Hwan Cho, MD, PhD",{"facility":155,"status":42,"city":156,"state":25,"zip":25,"country":45,"countryCode":25,"cosmosGeoPoint":157,"geoPoint":161,"contacts":162},"CHA Bundang Medical Center","Gyeonggi-do",{"type":47,"coordinates":158},[159,160],126.76917,37.58944,{"lat":160,"lon":159},[163,166],{"name":164,"role":32,"phone":25,"phoneExt":25,"email":165},"Seung Yul Lee, MD, PhD","seungyul79@gmail.com",{"name":164,"role":29,"phone":25,"phoneExt":25,"email":25},{"facility":168,"status":42,"city":169,"state":25,"zip":25,"country":45,"countryCode":25,"cosmosGeoPoint":170,"geoPoint":174,"contacts":175},"Wonkwang University Hospital","Iksan",{"type":47,"coordinates":171},[172,173],126.95444,35.94389,{"lat":173,"lon":172},[176,179],{"name":177,"role":32,"phone":25,"phoneExt":25,"email":178},"Kyeong Ho Yun, MD, PhD","ards7210@wku.ac.kr",{"name":177,"role":29,"phone":25,"phoneExt":25,"email":25},{"facility":181,"status":42,"city":182,"state":25,"zip":25,"country":45,"countryCode":25,"cosmosGeoPoint":183,"geoPoint":187,"contacts":188},"Inje University College of Medicine, Ilsan Paik Hospital","Ilsan",{"type":47,"coordinates":184},[185,186],129.43333,35.5,{"lat":186,"lon":185},[189,192,193],{"name":190,"role":32,"phone":25,"phoneExt":25,"email":191},"Sung Woo Cho, MD, PhD","drswcho@hanmail.net",{"name":190,"role":29,"phone":25,"phoneExt":25,"email":25},{"name":194,"role":118,"phone":25,"phoneExt":25,"email":25},"Sung-Eun Kim, MD, PhD",{"facility":196,"status":42,"city":197,"state":25,"zip":25,"country":45,"countryCode":25,"cosmosGeoPoint":198,"geoPoint":202,"contacts":203},"Gachon University Gil Medical Center","Incheon",{"type":47,"coordinates":199},[200,201],126.70515,37.45646,{"lat":201,"lon":200},[204,207,208],{"name":205,"role":32,"phone":25,"phoneExt":25,"email":206},"Albert Youngwoo Jang, MD, PhD","albert.jang.md@gmail.com",{"name":205,"role":29,"phone":25,"phoneExt":25,"email":25},{"name":209,"role":118,"phone":25,"phoneExt":25,"email":25},"Joon-Pyo Lee, MD, PhD",{"facility":211,"status":42,"city":197,"state":25,"zip":25,"country":45,"countryCode":25,"cosmosGeoPoint":212,"geoPoint":214,"contacts":215},"International St. Mary's Hospital",{"type":47,"coordinates":213},[200,201],{"lat":201,"lon":200},[216,219],{"name":217,"role":32,"phone":25,"phoneExt":25,"email":218},"Hyung Bok Park, MD, PhD","hyungbok7@gmail.com",{"name":217,"role":29,"phone":25,"phoneExt":25,"email":25},{"facility":221,"status":42,"city":222,"state":25,"zip":25,"country":45,"countryCode":25,"cosmosGeoPoint":223,"geoPoint":227,"contacts":228},"Gyeongsang National University Hospital","Jinju",{"type":47,"coordinates":224},[225,226],128.08472,35.19278,{"lat":226,"lon":225},[229,232,233,235],{"name":230,"role":32,"phone":25,"phoneExt":25,"email":231},"Jin Sin Koh, MD, PhD","kjs0175@gmail.com",{"name":230,"role":29,"phone":25,"phoneExt":25,"email":25},{"name":234,"role":118,"phone":25,"phoneExt":25,"email":25},"Hangyul Kim, MD, PhD",{"name":236,"role":118,"phone":25,"phoneExt":25,"email":25},"Min Gyu Kang, MD, PhD",{"facility":238,"status":42,"city":239,"state":25,"zip":25,"country":45,"countryCode":25,"cosmosGeoPoint":240,"geoPoint":244,"contacts":245},"Seoul National University Bundang Hospital","Seongnam",{"type":47,"coordinates":241},[242,243],127.7548,36.4052,{"lat":243,"lon":242},[246,249],{"name":247,"role":32,"phone":25,"phoneExt":25,"email":248},"Ki-Hyun Jeon, MD","imcardio@gmail.com",{"name":247,"role":29,"phone":25,"phoneExt":25,"email":25},{"facility":5,"status":42,"city":43,"state":25,"zip":251,"country":45,"countryCode":25,"cosmosGeoPoint":252,"geoPoint":254,"contacts":255},"06351",{"type":47,"coordinates":253},[49,50],{"lat":50,"lon":49},[256,257,258,260,262,264,266,268],{"name":28,"role":32,"phone":33,"phoneExt":25,"email":34},{"name":28,"role":29,"phone":25,"phoneExt":25,"email":25},{"name":259,"role":118,"phone":25,"phoneExt":25,"email":25},"Ki-Hong Choi, MD, PhD",{"name":261,"role":118,"phone":25,"phoneExt":25,"email":25},"Taek Kyu Park, MD, PhD",{"name":263,"role":118,"phone":25,"phoneExt":25,"email":25},"Jeong Hoon Yang, MD, PhD",{"name":265,"role":118,"phone":25,"phoneExt":25,"email":25},"Young Bin Song, MD, PhD",{"name":267,"role":118,"phone":25,"phoneExt":25,"email":25},"Joo Yong Hahn, MD, PhD",{"name":269,"role":118,"phone":25,"phoneExt":25,"email":25},"Sang Yoon Lee, MD, PhD",{"facility":271,"status":42,"city":43,"state":25,"zip":25,"country":45,"countryCode":25,"cosmosGeoPoint":272,"geoPoint":274,"contacts":275},"Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine",{"type":47,"coordinates":273},[49,50],{"lat":50,"lon":49},[276,279,282,283],{"name":277,"role":32,"phone":25,"phoneExt":25,"email":278},"Seung-Jae Lee, MD, PhD","sjjy1028@daum.net",{"name":280,"role":32,"phone":25,"phoneExt":25,"email":281},"Woochan Kwon, MD, PhD","danced1@naver.com",{"name":280,"role":118,"phone":25,"phoneExt":25,"email":25},{"name":277,"role":118,"phone":25,"phoneExt":25,"email":25},{"facility":285,"status":42,"city":43,"state":25,"zip":25,"country":45,"countryCode":25,"cosmosGeoPoint":286,"geoPoint":288,"contacts":289},"Korea University Guro Hospital",{"type":47,"coordinates":287},[49,50],{"lat":50,"lon":49},[290,293],{"name":291,"role":32,"phone":25,"phoneExt":25,"email":292},"Dong-Oh Kang, MD, PhD","gelly9@naver.com",{"name":291,"role":29,"phone":25,"phoneExt":25,"email":25},{"facility":295,"status":42,"city":43,"state":25,"zip":25,"country":45,"countryCode":25,"cosmosGeoPoint":296,"geoPoint":298,"contacts":299},"Seoul National University Boramae Medical Center",{"type":47,"coordinates":297},[49,50],{"lat":50,"lon":49},[300,303],{"name":301,"role":32,"phone":25,"phoneExt":25,"email":302},"Hyun Sung Joh, MD, PhD","wingx4@naver.com",{"name":301,"role":29,"phone":25,"phoneExt":25,"email":25},{"facility":305,"status":42,"city":306,"state":25,"zip":25,"country":45,"countryCode":25,"cosmosGeoPoint":307,"geoPoint":311,"contacts":312},"Ajou University Hospital","Suwon",{"type":47,"coordinates":308},[309,310],127.00889,37.29111,{"lat":310,"lon":309},[313,316],{"name":314,"role":32,"phone":25,"phoneExt":25,"email":315},"Hong-Seok Lim, MD,PhD","hslimmd@hanmail.net",{"name":314,"role":29,"phone":25,"phoneExt":25,"email":25},{"facility":318,"status":42,"city":319,"state":25,"zip":25,"country":45,"countryCode":25,"cosmosGeoPoint":320,"geoPoint":324,"contacts":325},"Uijeongbu ST. Mary's Hospital","Uijeongbu-si",{"type":47,"coordinates":321},[322,323],127.0474,37.7415,{"lat":323,"lon":322},[326,329,330],{"name":327,"role":32,"phone":25,"phoneExt":25,"email":328},"Chan Joon Kim, MD, PhD","godandsci@naver.com",{"name":327,"role":29,"phone":25,"phoneExt":25,"email":25},{"name":331,"role":118,"phone":25,"phoneExt":25,"email":25},"Seong Hyeon Bu, MD, PhD",{"facility":333,"status":42,"city":334,"state":25,"zip":25,"country":45,"countryCode":25,"cosmosGeoPoint":335,"geoPoint":339,"contacts":340},"Ulsan University Hospital","Ulsan",{"type":47,"coordinates":336},[337,338],129.31667,35.53722,{"lat":338,"lon":337},[341,344],{"name":342,"role":32,"phone":25,"phoneExt":25,"email":343},"Eun-Seok Shin, MD, PhD","sesim1989@gmail.com",{"name":342,"role":29,"phone":25,"phoneExt":25,"email":25},{"facility":346,"status":42,"city":347,"state":25,"zip":25,"country":45,"countryCode":25,"cosmosGeoPoint":348,"geoPoint":352,"contacts":353},"Wonju Severance Christian Hospital","Wŏnju",{"type":47,"coordinates":349},[350,351],127.94528,37.35139,{"lat":351,"lon":350},[354,357,359],{"name":355,"role":32,"phone":25,"phoneExt":25,"email":356},"Sung Gyun Ahn, MD, PhD","sgahn@yonsei.ac.kr",{"name":358,"role":118,"phone":25,"phoneExt":25,"email":25},"Jung-Hee Lee, MD, PhD",{"name":355,"role":29,"phone":25,"phoneExt":25,"email":25},{"type":29,"investigatorFullName":361,"investigatorTitle":362,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Joo Myung Lee","Associate Professor",[364,366,367,368,370,372,373,375,377,378,380,382,383,384,386,388,390,391,392,393,394],{"name":365,"class":6},"Chonnam National University Hospital",{"name":238,"class":6},{"name":138,"class":6},{"name":369,"class":6},"The Catholic University of Korea",{"name":371,"class":6},"Keimyung University Dongsan Medical Center",{"name":346,"class":6},{"name":374,"class":6},"SMG-SNU Boramae Medical Center",{"name":376,"class":6},"Kangbuk Samsung Hospital, Sungkyunkwan University",{"name":285,"class":6},{"name":379,"class":6},"Inje University Ilsan Paik Hospital",{"name":211,"class":381},"UNKNOWN",{"name":107,"class":6},{"name":41,"class":6},{"name":385,"class":6},"Ajou University School of Medicine",{"name":387,"class":381},"Changwon Patima Hospital",{"name":389,"class":6},"Bundang CHA Hospital",{"name":333,"class":6},{"name":196,"class":6},{"name":58,"class":6},{"name":84,"class":6},{"name":168,"class":6},"100618290","artificial-intelligence-driven-medipixel-fractional-flow-reserve-versus-invasive-fractional-flow-reserve-guided-pci-trial-aim-ffr-trial-100618290",false,"NCT07329699","Artificial Intelligence-Driven Medipixel Fractional Flow Reserve Versus Invasive Fractional Flow Reserve-Guided PCI Trial (AIM-FFR Trial)","Artificial Intelligence-Driven Angiography-Based Fractional Flow Reserve Versus Invasive Fractional Flow Reserve-Guided PCI","AIM-FFR","Inclusion Criteria:\n\n1. Subject must be at least 19 years of age\n2. Eligible for coronary angiography and\u002For percutaneous coronary intervention.\n3. Chronic coronary syndrome or acute coronary syndrome (non-culprit vessels only)\n4. Coronary artery disease in one or more native major epicardial vessels or their branches with reference vessel diameter of at least 2.5mm and with visually assessed coronary stenosis in which the physiological severity of the lesion is questionable (typically 40-90% diameter stenosis).\n5. Subject who is able to understand risks, benefits and treatment alternatives and sign informed consent voluntarily.\n\nExclusion Criteria:\n\n1. Patients unable to provide informed consent\n2. Patients with known intolerance to aspirin, P2Y12 inhibitors, or components of drug-eluting stents and drug-coated balloons\n3. Patients with coronary artery bypass grafting\n4. Patients who have non-cardiac co-morbid conditions with life expectancy \\\u003C1 year\n5. Patients with cardiogenic shock or cardiac arrest\n6. Patients with severe left ventricular systolic dysfunction (ejection fraction \\\u003C30%)\n7. Patients with severe valvular heart disease requiring open heart surgery\n8. Pregnant or lactating women\n9. Angiographic exclusion criteria\n\n   * Culprit vessel of patients with ST-elevation myocardial infarction (target lesions in non-culprit vessel can be enrolled)\n   * Chronic total occlusion (target lesions in vessels without chronic total occlusion can be enrolled)\n   * Ostial stenosis in left man coronary artery or right coronary artery\n   * Severe tortuosity of any target vessel\n   * Severe overlap in the stenosed segment\n   * Poor image quality precluding identification of vessel contours","ALL","19 Years",{"count":406,"type":407},2100,"ESTIMATED","INTERVENTIONAL",[410],"NA","The AIM-FFR trial is a prospective, multi-center, open-label, randomized controlled, non-inferiority trial. The current trial will evaluate non-inferiority of MPFFR-guided PCI, compared with invasive FFR-guided PCI in patients with coronary artery disease.",[413,414,415],"Coronary Artery Disease","Chronic Coronary Syndrome","Acute Coronary Syndrome",[417,418,419],"Coronary artery stenosis","Fractional flow reserve","Prognosis","2026-04-21",{"date":422,"type":423},"2026-04-23","ACTUAL",{"date":425,"type":423},"2026-03-18",{"date":427,"type":407},"2029-12-31",{"name":5,"class":6},23]