[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100140521":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":29,"responsibleParty":69,"collaborators":72,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":10,"eligibilityCriteria":85,"healthyVolunteers":81,"sex":86,"minAge":87,"maxAge":10,"enrollmentInfo":88,"targetDuration":10,"studyType":91,"phases":10,"briefSummary":92,"conditions":93,"keywords":95,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":112},{"fullName":5,"class":6},"University of Utah","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Advanced Heart Failure Therapy Group",null,"Patients diagnosed with end stage heart failure undergoing either VAD implantation or heart transplantation.",{"label":13,"type":10,"description":14,"interventionNames":10},"Normal Hearts Group","Control samples will be obtained from individuals undergoing other types of cardiac surgery during which it is routine to discard some tissue intraoperatively.",[16],{"name":17,"affiliation":18,"role":19},"Stavros Drakos, M.D., Ph.D.","University of Utah Health Sciences Center & VA Salt Lake City Health Care System","PRINCIPAL_INVESTIGATOR",[21,26],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"John Kirk","CONTACT","801-585-2944","john.kirk@hsc.utah.edu",{"name":17,"role":23,"phone":27,"phoneExt":10,"email":28},"801-585-2340","stavros.drakos@hsc.utah.edu",[30,49,61],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Intermountain Medical Center","RECRUITING","Murray","Utah","84157","United States","US",{"type":39,"coordinates":40},"Point",[41,42],-111.88799,40.66689,{"lat":42,"lon":41},[45],{"name":46,"role":23,"phone":47,"phoneExt":10,"email":48},"Abdallah Kfoury, M.D.","801-507-7000","a.kfoury@imail.org",{"facility":50,"status":32,"city":51,"state":34,"zip":52,"country":36,"countryCode":37,"cosmosGeoPoint":53,"geoPoint":57,"contacts":58},"University of Utah Health Sciences Center","Salt Lake City","84132",{"type":39,"coordinates":54},[55,56],-111.89105,40.76078,{"lat":56,"lon":55},[59],{"name":60,"role":23,"phone":27,"phoneExt":10,"email":28},"Stavros Drakos, M.D, Ph.D",{"facility":62,"status":32,"city":51,"state":34,"zip":63,"country":36,"countryCode":37,"cosmosGeoPoint":64,"geoPoint":66,"contacts":67},"VA Salt Lake City Health Care System","84148",{"type":39,"coordinates":65},[55,56],{"lat":56,"lon":55},[68],{"name":60,"role":23,"phone":27,"phoneExt":10,"email":28},{"type":19,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"STAVROS G DRAKOS","Principal Investigator",[73,75,77],{"name":74,"class":6},"Intermountain Health Care, Inc.",{"name":62,"class":76},"FED",{"name":78,"class":76},"Hunter Holmes McGuire VA Medical Center","100140521","assessing-changes-in-myocardial-tissue-and-blood-in-patients-with-advanced-heart-disease-100140521",false,"NCT01099982","Assessing Changes in Myocardial Tissue and Blood in Patients With Advanced Heart Disease","Assessing Changes in Myocardial Tissue and Blood in Patients With Advanced Heart Disease, Effects of Mechanical Unloading on Myocardial Function and Structure in Humans","Inclusion Criteria:\n\n* \\>18 years of age diagnosed with heart failure undergoing either LVAD implantation or heart transplantation\n* 13 to 18 years of age, specifically, older children with heart failure whose body mass index is large enough to accommodate and LVAD\n\nExclusion Criteria:\n\n* Neither patient nor patient representative understands spoken English\n* Neither patient nor patient's personal representative is willing to give written consent for participation.","ALL","13 Years",{"count":89,"type":90},300,"ESTIMATED","OBSERVATIONAL","Hypothesis:\n\nTissue and serum samples collected from end-stage heart failure patients receiving left ventricular assist device implantation (LVAD) or heart transplantation will provide information regarding the basic science of heart disease. Tissue and serum samples collected from a limited numbers of \"healthy controls\" (donor grafts that were not utilized for heart transplantation) will serve as a comparator in research database projects.\n\nDesign:\n\nThis is a registry project; there are no investigational treatments, drug or procedures associated with participation in registry activities. This project is an organized functional data and tissue data gathering and storing (database) endeavor with specific focus on the functional, structural, and molecular aspects of heart failure. Data collection will not immediately influence the course of treatment for any patient.",[94],"Congestive Heart Failure",[94,96,97,98,99,100,101,102],"Left Ventricular Assist Device","LVAD","Myocardium","Remodeling","Microvasculature","Fibrosis","Cardiac Transplant","2025-07-09",{"date":105,"type":106},"2025-07-15","ACTUAL",{"date":108,"type":106},"2008-09",{"date":110,"type":90},"2028-01",{"name":5,"class":6},3]