[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100312194":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":37,"centralContacts":45,"locations":55,"responsibleParty":76,"collaborators":27,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":83,"acronym":27,"eligibilityCriteria":84,"healthyVolunteers":81,"sex":85,"minAge":86,"maxAge":27,"enrollmentInfo":87,"targetDuration":27,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":97,"overallStatus":58,"whyStopped":27,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"University of California, San Diego","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Control Group","ACTIVE_COMPARATOR","Patients, as outlined by NASCET criteria, will have between 50 symptomatic stenosis or 70% asymptomatic stenosis of the carotid artery. Patients, undergoing carotid artery stenting for carotid stenosis, will undergo cognitive testing at 2 time points before intervention (1 months, and 2 months). The two preoperative time points will serve as the control group.",[13,14],"Diagnostic Test: Neurocognitive Assessments","Diagnostic Test: Measurements of inflammatory biomarkers",{"label":16,"type":17,"description":18,"interventionNames":19},"Intervention Group","EXPERIMENTAL","Patients, as outlined by NASCET criteria, will have between 50 symptomatic stenosis or 70% asymptomatic stenosis of the carotid artery. Patients, undergoing carotid artery stenting for carotid stenosis, will undergo cognitive testing at 2 time points after invention (1 month and 2 months). The two postoperative time points will serve as the intervention group.",[13,14,20],"Procedure: Carotid Artery Stenting",[22,28,32],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DIAGNOSTIC_TEST","Neurocognitive Assessments","Patients will undergo carotid artery stenting for 50-70% carotid artery stenosis. Prior to surgery patients will undergo a battery of neurocogntive assessments 1 month and 2 months prior to surgery.",[9,16],null,{"type":23,"name":29,"description":30,"armGroupLabels":31,"otherNames":27},"Measurements of inflammatory biomarkers","Patients will undergo carotid artery stenting for 50-70% carotid artery stenosis. After surgery, patients will undergo blood draws to measure for inflammatory biomarkers.",[9,16],{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":27},"PROCEDURE","Carotid Artery Stenting","Patients will undergo carotid artery stenting for 50-70% carotid artery stenosis.",[16],[38,42],{"name":39,"affiliation":40,"role":41},"Alexander A Khalessi, MD","UC San Diego","PRINCIPAL_INVESTIGATOR",{"name":43,"affiliation":40,"role":44},"David R Santiago-Dieppa, MD","STUDY_DIRECTOR",[46,51],{"name":47,"role":48,"phone":49,"phoneExt":27,"email":50},"Alexander Khalessi, MD","CONTACT","(619) 543-5540","akhalessi@ucsd.edu",{"name":52,"role":48,"phone":53,"phoneExt":27,"email":54},"ARVIN WALI, BA, MAS","7149282722","AWALI@UCSD.EDU",[56],{"facility":57,"status":58,"city":59,"state":60,"zip":61,"country":62,"countryCode":63,"cosmosGeoPoint":64,"geoPoint":69,"contacts":70},"UCSD Medical Center","RECRUITING","San Diego","California","92103","United States","US",{"type":65,"coordinates":66},"Point",[67,68],-117.16472,32.71571,{"lat":68,"lon":67},[71,74],{"name":43,"role":48,"phone":72,"phoneExt":27,"email":73},"6195435078","drsantiagodieppa@ucsd.edu",{"name":43,"role":75,"phone":27,"phoneExt":27,"email":27},"SUB_INVESTIGATOR",{"type":41,"investigatorFullName":77,"investigatorTitle":78,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"Alexander A. Khalessi MD MS FAANS","Acting Clinical Chief UCSD","100312194","assessing-neurocognition-after-cerebrovascular-intervention-100312194",false,"NCT03344276","Assessing Neurocognition After Cerebrovascular Intervention","Inclusion Criteria:\n\n* patients \\>18 years of age\n* ultrasound evidence of carotid stenosis; in which the patient has either 50% or greater symptomatic carotid stenosis or 70% or greater asymptomatic carotid stenosis.\n\nExclusion Criteria:\n\n1. patients \\\u003C18 years of age\n2. patients with without compatibility for MRI\n3. patients requiring carotid stenting for reasons not related to long-standing stenosis\n4. patients requiring emergency carotid stenting for acute symptoms such as crescendo transient ischemic attacks, intolerance of physiologic blood pressure.\n5. Patients that do not have appropriate capacity (i.e. understand the risks and benefits associated with this study) or are unable to consent for themselves will not be included in this study.","ALL","18 Years",{"count":88,"type":89},20,"ESTIMATED","INTERVENTIONAL",[92],"NA","Decreased blood flow to the brain can cause decreased cognitive function. Carotid disease can result in decreased blood flow to the brain. The investigators seek to assess this relationship prospectively through performing a battery of neurocognitive assessments, collection of serum markers of inflammation, and through neuroimaging at two points before intervention (2 months and 1 month before stenting) and at two points after intervention (1 month and 2 months after intervention). The goal is to provide prospective evidence to identify the extent to which carotid stenosis and hypoperfusion of the brain results in diminished neurocognitive performance, and see if serum biomarkers before and after stenting correlate with these findings.",[95,96],"Carotid Artery Diseases","Neurocognitive Dysfunction",[98,99,100,101],"carotid stenosis","neurocognition","carotid stenting","circle of willis","2025-02-03",{"date":104,"type":105},"2025-02-06","ACTUAL",{"date":107,"type":105},"2021-07-15",{"date":109,"type":89},"2025-12",{"name":5,"class":6},1]