[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100539695":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":23,"centralContacts":28,"locations":35,"responsibleParty":51,"collaborators":53,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":10,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":10,"studyType":70,"phases":10,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":38,"whyStopped":10,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Instituto Valenciano de Infertilidade de Lisboa","NETWORK",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Natural proliferative phase frozen embryo transfer (NPP-FET)",null,"When the endometrial thickness is at least 7 mm, vaginal micronized progesterone will be initiated at 400mg every 12 hours, as per standard clinical practice, when the dominant follicle is at least 13 mm, serum estradiol (E2) levels are \\>80 pg\u002Fml, and serum progesterone levels are \\\u003C1.5ng\u002Fml. One embryo will be transferred on the fifth day of progesterone supplementation under ultrasound guidance. Progesterone will be continued until the 11th week of pregnancy.",[13],"Procedure: Natural proliferative phase frozen embryo transfer",{"label":15,"type":10,"description":16,"interventionNames":10},"Natural cycle frozen embryo transfer (NC-FET)","When the mean dominant follicle diameter was at least 17 mm and the endometrial thickness was at least 7 mm, serum E2, progesterone and luteinizing hormone (LH) were evaluated. If a spontaneously LH peak was detected (E2\\>80 pg\u002Fml, LH peak \\>18 mIU\u002FmL with progesterone level \\\u003C1.5 ng\u002FmL), vaginal micronized progesterone was started from the evening of ovulation at a dose of 200 mg every 12 hours. Conversely, whenever a LH peak was not detected (E2\\>80 pg\u002Fml, LH \\\u003C18mIU\u002Fml and progesterone \\\u003C1,5 ng\u002Fml), r-hCG 250µg (Ovitrelle®) was administered subcutaneously, followed, 48 hours later, by daily administration of 200 mg micronized vaginal progesterone every 12 hours. One embryo was transferred 7 days after r-hCG administration or 6 days after LH peak detection. Progesterone was continued until the 8th week of pregnancy.",[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"PROCEDURE","Natural proliferative phase frozen embryo transfer","When endometrial thickness is above 7 mm, vaginal micronized progesterone will be administered 400mg 12\u002F12h when the dominant follicle is at least 13 mm, serum estradiol (E2) levels are \\>80 pg\u002Fml, and serum progesterone levels are \\\u003C1.5ng\u002Fml. Embryo transfer will be performed on the fifth day of progesterone.",[9],[24],{"name":25,"affiliation":26,"role":27},"Ana R Neves, MP","Instutito Valenciano de Infertilidade de Lisboa (IVI-RMA Lisboa)","PRINCIPAL_INVESTIGATOR",[29],{"name":30,"role":31,"phone":32,"phoneExt":33,"email":34},"Ana R Neves, MD, PhD","CONTACT","218 503 210","00351","ana.neves@ivirma.com",[36],{"facility":37,"status":38,"city":39,"state":10,"zip":10,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Instituto Valenciano de Infertilidade","RECRUITING","Lisbon","Portugal","PT",{"type":43,"coordinates":44},"Point",[45,46],-9.1498,38.72509,{"lat":46,"lon":45},[49],{"name":50,"role":31,"phone":10,"phoneExt":10,"email":10},"Samuel Santos-Ribeiro, MD PhD",{"type":52,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[54],{"name":55,"class":56},"Gedeon Richter Ltd.","INDUSTRY","100539695","assessing-the-convenience-of-natural-proliferative-phase-frozen-embryo-transfer-100539695",false,"NCT06307184","Assessing the Convenience of Natural Proliferative Phase Frozen Embryo Transfer","Assessing the Convenience of Natural Proliferative Phase Frozen Embryo Transfer: an Ambispective Cohort Study","Inclusion Criteria:\n\n* Endometrial thickness ≥ 7 mm on the day of starting progesterone-based luteal phase support (LPS)\n* Serum progesterone levels \\\u003C1.5 ng\u002Fml on the day of starting progesterone-based LPS\n* LPS with micronized progesterone 400mg b.i.d.\n* Regular cycles (\\>24 days, ≤ 38 days)\n* IVF\u002FICSI with donated oocytes\n* Single blastocyst stage embryo transfer\n* First or second embryo transfer from the same cohort\n\nExclusion Criteria:\n\n* Use of exogenous ovarian stimulation during FET\n* Untreated hydrosalpinx, polyp, submucous myomas or severe adenomyosis\n* Recurrent pregnancy loss (≥ 3 previous pregnancy losses)\n* Recurrent implantation failure with embryos from oocyte donation (≥ 3 previous failed embryo transfers)\n* Personalized initiation of exogenous progesterone according to a previous endometrial receptivity assay test","FEMALE","18 Years","49 Years",{"count":68,"type":69},530,"ESTIMATED","OBSERVATIONAL","This study will assess the convenience of the natural proliferative phase frozen embryo transfer (NPP-FET) in terms of number of number of appointments needed before cycle scheduling.",[73],"Frozen Embryo Transfer",[75,76,77,78],"Endometrial preparation","Natural cycle","Progesterone","Pregnancy","2026-02-20",{"date":81,"type":82},"2026-02-23","ACTUAL",{"date":84,"type":82},"2024-02-23",{"date":86,"type":69},"2026-12",{"name":5,"class":6},1]