[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100462701":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":28,"centralContacts":32,"locations":41,"responsibleParty":61,"collaborators":63,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":10,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":74,"minAge":10,"maxAge":10,"enrollmentInfo":75,"targetDuration":10,"studyType":78,"phases":10,"briefSummary":79,"conditions":80,"keywords":84,"overallStatus":44,"whyStopped":10,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Tang-Du Hospital","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"chemotherapy",null,"Premenopausal breast cancer patients receiving chemotherapy (including preoperative neoadjuvant chemotherapy) and endocrine therapy after surgery",[13],"Device: PET\u002FMRI, psychobehavioral tests and questionnaires, serum biomarkers and stool sample",{"label":15,"type":10,"description":16,"interventionNames":17},"Endocrine therapy","Premenopausal breast cancer patients receiving endocrine therapy alone after surgery",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Healthy control","Healthy non-cancer controls",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":10},"DEVICE","PET\u002FMRI, psychobehavioral tests and questionnaires, serum biomarkers and stool sample","Neuroimaging data were collected by integrated PET\u002FMRI machine, and collected the psychobehavioral data, the serum and stool samples of participants.",[15,19,9],[29],{"name":30,"affiliation":5,"role":31},"Menghui Yuan, phd","PRINCIPAL_INVESTIGATOR",[33,37],{"name":30,"role":34,"phone":35,"phoneExt":10,"email":36},"CONTACT","0086-13519196610","yuanmenghui@163.com",{"name":38,"role":34,"phone":39,"phoneExt":10,"email":40},"Lijun Bai, phd","0086-15129034948","bailijun@xjtu.edu.cn",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Tangdu Hospital","RECRUITING","Xi'an","Shaanxi","710038","China","CN",{"type":51,"coordinates":52},"Point",[53,54],108.92861,34.25833,{"lat":54,"lon":53},[57,59],{"name":58,"role":34,"phone":35,"phoneExt":10,"email":36},"Menghui Yuan, PHD",{"name":60,"role":34,"phone":39,"phoneExt":10,"email":40},"Lijun Bai, PHD",{"type":62,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[64],{"name":65,"class":6},"Xi'an Jiaotong University","100462701","assessment-of-brain-cognitive-impairment-in-breast-cancer-100462701",false,"NCT05305092","Assessment of Brain Cognitive Impairment in Breast Cancer","Integrated PET\u002FMRI Study of Cognitive Impairment in Premenopausal Breast Cancer Patients After Chemotherapy or Endocrine Therapy","Inclusion Criteria:\n\n* Patients with primary stage I-II breast cancer.\n* Premenopausal women (menopausal status determined by National Comprehensive Cancer Network Breast Cancer Guidelines criteria).\n* No treatment other than surgery has been started (if neoadjuvant chemotherapy is required before surgery, enroll before chemotherapy starts).\n* Eastern Cooperative Oncology Group score of 0-1 points.\n* Can understand and complete various scales.\n* Right handedness.\n* Female subjects of childbearing potential must be willing to use a medically-approved high-efficiency contraceptive method (eg, intra-uterine device, birth control pill, or condom) for the duration of the study.\n* Sign the informed consent and voluntarily participate in this clinical observation.\n\nExclusion Criteria:\n\n* Central nervous system (CNS) disease, history of malignancy, chronic loss of consciousness, head trauma, and any disease affecting cognitive function.\n* Current or former epilepsy, dementia, or learning disabilities.\n* Past psychiatric history.\n* Past history of malignancy.\n* MRI related contraindications: pacemakers, defibrillators, hearing aids, insulin pumps, drug dose control devices and other metal implants; patients with severe hyperthermia; patients with claustrophobia.",true,"FEMALE",{"count":76,"type":77},90,"ESTIMATED","OBSERVATIONAL","To explore the cognitive impairment caused by chemotherapy and endocrine therapy in premenopausal breast cancer patients and to find biomarkers with early predictive effect on this cognitive impairment by using multimodal integrated PET\u002FMRI technology combined with psychobehavioral technology.",[81,82,83],"Breast Cancer","Chemo-brain","Endocrine Therapy",[85,86,87,88],"CRCI","psycho-behavioral technology","Integrated PET\u002FMRI technology","Biomarkers","2022-07-12",{"date":91,"type":92},"2022-07-13","ACTUAL",{"date":94,"type":92},"2022-05-31",{"date":96,"type":77},"2027-05-30",{"name":5,"class":6},1]