[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637057":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":10,"locations":24,"responsibleParty":44,"collaborators":10,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":10,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":56,"minAge":57,"maxAge":10,"enrollmentInfo":58,"targetDuration":61,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":10,"overallStatus":27,"whyStopped":10,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},{"fullName":5,"class":6},"Zhongda Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"AD",null,"This group consists of patients diagnosed with Atopic Dermatitis (AD) according to the Hanifin and Rajka criteria or the Williams diagnostic criteria.",[13],"Biological: blood sampling",{"label":15,"type":10,"description":16,"interventionNames":17},"Control","This group consists of healthy volunteers with no personal or family history of atopic dermatitis, asthma, allergic rhinitis, or other systemic inflammatory and autoimmune diseases.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"BIOLOGICAL","blood sampling","One-time peripheral venous blood collection and\u002For 4mm punch biopsy for biomarker analysis.",[9,15],[25],{"facility":26,"status":27,"city":28,"state":29,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"Zhongda Hospital, Southeast University","RECRUITING","Nanjing","Jiangsu","China","CN",{"type":33,"coordinates":34},"Point",[35,36],118.77778,32.06167,{"lat":36,"lon":35},[39],{"name":40,"role":41,"phone":42,"phoneExt":10,"email":43},"meihong Da","CONTACT","025-83272015","huyk1997@163.com",{"type":45,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Yakun Hu","Resident Physician","100637057","assessment-of-cfdna-sting-axis-as-a-potential-pathological-marker-in-atopic-dermatitis-100637057",false,"NCT07573735","Assessment of cfDNA-STING Axis as a Potential Pathological Marker in Atopic Dermatitis","An Observational Study on the Correlation Between Circulating Cell-free DNA and Skin Macrophage STING Pathway Activation in Patients With Atopic Dermatitis","Inclusion Criteria:\n\n* Age 18 years or older\n* Confirmed diagnosis of Atopic Dermatitis\n\nExclusion Criteria:\n\n* Use of systemic immunosuppressants, systemic corticosteroids, or biological agents within 4 weeks prior to enrollment\n* Use of topical treatments within 2 weeks prior to enrollment",true,"ALL","18 Years",{"count":59,"type":60},80,"ESTIMATED","1 Day","OBSERVATIONAL","Study Overview Atopic dermatitis (AD), commonly known as eczema, is a chronic inflammatory skin condition characterized by intense itching and skin barrier damage. While researchers know that the immune system is overactive in AD, it is difficult to measure the exact level of \"damage\" or \"inflammation\" happening deep within the skin using only a physical exam.\n\nThe Purpose of This Study This study investigates a specific \"danger signal\" called circulating cell-free DNA (cfDNA). When skin cells are damaged or die due to inflammation, they release tiny fragments of DNA into the bloodstream. The investigators believe these fragments might act as a trigger for the immune system, worsening the disease.\n\nWhat the Study Involves Researchers will collect blood samples and small skin biopsies from patients with AD and healthy volunteers.\n\nThe study aims to: Compare the levels of cfDNA in the blood of AD patients versus healthy individuals. Determine if higher levels of cfDNA correlate with more severe skin symptoms (measured by scores like SCORAD and EASI). Examine how immune cells in the skin (macrophages) respond to these DNA fragments through a specific biological switch called the STING pathway.\n\nPotential Impact By understanding this \"damage-signal\" loop, this research may lead to new ways for doctors to monitor AD severity through simple blood tests and could identify new targets for future anti-inflammatory treatments.",[65],"Atopic Dermatitis (Eczema)","2026-06-09",{"date":68,"type":69},"2026-06-11","ACTUAL",{"date":71,"type":69},"2026-02-01",{"date":73,"type":60},"2026-07-31",{"name":5,"class":6},1]